A5002987520- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- interferon and immune responses
- RNA modifications and cancer
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Extracellular vesicles in disease
- Galectins and Cancer Biology
- Helicobacter pylori-related gastroenterology studies
- Bacterial Infections and Vaccines
- Alzheimer's disease research and treatments
- Ubiquitin and proteasome pathways
- Cholinesterase and Neurodegenerative Diseases
- Virus-based gene therapy research
- Gut microbiota and health
- Lung Cancer Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Eosinophilic Esophagitis
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Ferroptosis and cancer prognosis
Nanchang University
2016-2025
First Affiliated Hospital of Jiangxi Medical College
2003-2025
Central South University
2025
First Affiliated Hospital of Nanchang University
2020-2024
Jiangnan University
2023-2024
State Key Laboratory of Food Science and Technology
2023-2024
Sichuan University
2024
State Key Laboratory of Respiratory Disease
2024
Second Affiliated Hospital of Nanchang University
2023
Guangzhou Maritime College
2023
The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N6-methyladenosine (m6A) residues in mRNA vitro and inside cells. the first RNA demethylase discovered also serves a major regulatory function mammals. Together with structure-based virtual screening biochemical analyses, we report identification of several small-molecule inhibitors human demethylase. most potent compound, natural product rhein, which neither structural mimic 2-oxoglutarate nor chelator metal ion,...
Bacterial outer membrane vesicles (OMVs) play a vital role in the mechanism of host-pathogen communication, while emerging evidence suggests that OMVs regulate host immune responses through differentially packaged small noncoding RNAs (sncRNAs) to target mRNA function. Therefore, we identified sncRNAs Helicobacter pylori and showed transfer OMV human gastric adenocarcinoma cells this study. Our data revealed (sR-2509025 sR-989262) were enriched OMVs, reduced lipopolysaccharide or OMV-induced...
ABSTRACT As the trend of antibiotic resistance has increased, prevention and treatment Helicobacter pylori infection have been challenged by fact that no vaccines preventing H. are available. Scientists continue to make sustained efforts find better vaccine formulations adjuvants eradicate this chronic infection. In study, we systemically analyzed protein composition potential function outer-membrane vesicles (OMVs) derived from gerbil-adapted strain 7.13. total, identified 169 proteins in...
A number of recent discoveries indicate that huperzine A, an active herbal medicine employed for the treatment Alzheimer's disease (AD) in China, can afford neuroprotection on vitro and vivo models related to mitochondrial dysfunction. Howev
Summary The increasing incidence of vulvovaginal candidiasis ( VVC ) and the emergence fluconazole resistance are an indisputable fact. However, little information is available regarding correlation between in vaginal Candida albicans expression drug efflux pump genes. In this study, we investigated species distribution, susceptibility profiles mechanisms strains. total, 785 clinical isolates were collected from patients with . C. was most frequently isolated n = 529) followed by glabrata...
Background Over the last two decades, prevalence of colistin resistance among members Enterobacteriaceae has been increasing, particularly Klebsiella pneumoniae isolates; this limits potential use and leads to worsened clinical outcomes. Methods We investigated genetic characteristics colistin-resistant K. (COLR-KP) in isolates using genomic sequencing. Results In total, 53 K . (4.5%, 53/1,171) were confirmed as COLR-KP, which eight carried mobile ( mcr ) gene. Although overall rate (0.7%,...
Helicobacter pylori causes globally prevalent infections that are highly related to chronic gastritis and even development of gastric carcinomas. With the increase antibiotic resistance, scientists have begun search for better vaccine design strategies eradicate H. colonization. However, while current prefer formulate vaccines with a single antigen, their potential has not yet been fully realized. Outer membrane vesicles (OMVs) platform since they could deliver multiple antigens. In this...
RNASET2 (Ribonuclease T2) functions as a tumor suppressor in preventing ovarian tumorigenesis. However, the mechanisms underlying regulation of protein are completely unknown. Here we identified F-box FBXO6, substrate recognition subunit an SCF (Skp1-Cul1-F-box protein) complex, ubiquitin E3 ligase for RNASET2. We found that interaction between FBXO6 and induced instability through ubiquitin-mediated proteasome degradation pathway. promoted K48-dependent ubiquitination via its FBA domain....
Abstract Heterogeneous nuclear ribonucleoprotein L (hnRNPL) is a type of RNA binding protein that highly expressed in variety tumors and plays vital role tumor progression. However, its post-translational regulation through ubiquitin-mediated proteolysis the cellular mechanism responsible for proteasomal degradation remains unclear. F-box proteins (FBPs) function as substrate recognition subunits SCF ubiquitin ligase complexes directly bind to substrates. The aberrant expression or mutation...
Colon cancer is the second leading cause of cancer-related death, and there are few effective therapies for colon cancer. This study explored use coxsackievirus group B3 (CVB3) as an oncolytic virus treatment In this study, we verified that CVB3 induces death cell lines by directly observing morphology Western blot results, observed effects constructing immunodeficient nude mice model. Our data show pyroptosis in lines. Mechanistically, demonstrated causes cleavage gasdermin E (GSDME), but...
Bacterial extracellular vesicles (BEVs) are naturally occurring functional structures that play critical roles in bacterial life processes. These vesicles, commonly known as outer membrane (OMVs), were first found to be released by Gram-negative bacteria; however, it has since been confirmed Gram-positive bacteria also secrete BEVs. As research advances, BEVs increasingly utilized diverse applications, including vaccine development and drug delivery. Nevertheless, the effective employment of...
Recent researches indicated a down-regulation of Human beta-defensin2 (HBD2) expression in cervical cancer cells, but the mechanism and clinical significance is not clear yet. In this paper, based on data from TCGA database, bioinformatics analysis provided by UALCAN server was used. The HBD2 mRNA levels were tested with RT-qPCR cells protein concentration cell cultural supernatant assayed ELISA. When gene papillomavirus type 16 E7 oncoprotein (HPV16 E7) overexpression or knockdown, ASK1 p38...
Fluconazole resistance of Candida albicans has been reported to be the result one or more specific point mutations in ERG11 gene. In this study, we amplified and sequenced entire coding sequence 72 isolates C. search for possible mutations. Twenty-seven silent 14 missense were identified. While K342R V437I found as single-amino-acid changes Erg11p, other detected simultaneously individual isolates. Several different clinical had same pattern multiple amino acid alternations: (1) A114S with...