A5103129523- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Ultrasound in Clinical Applications
- Lipid metabolism and disorders
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Pleural and Pulmonary Diseases
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Neurological Disease Mechanisms and Treatments
- Cancer Research and Treatments
- Traditional Chinese Medicine Studies
- RNA Research and Splicing
- Ion Channels and Receptors
- Pain Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Metabolism and Genetic Disorders
- Hippo pathway signaling and YAP/TAZ
- Acute Ischemic Stroke Management
- Circular RNAs in diseases
China Medical University
2010-2022
Saint Francis University
2021-2022
Hubei University of Medicine
2022
Taihe Hospital
2022
University of South China
2022
Daping Hospital
2016-2021
Army Medical University
2016-2021
First Affiliated Hospital of Wannan Medical College
2021
First Hospital of China Medical University
2013-2020
Taizhou First People's Hospital
2019
It is important to develop a surgical technique reduce dissemination of tumor cells into the blood during surgery.To compare outcomes different sequences vessel ligation surgery on and survival in patients with non-small cell lung cancer.This multicenter, randomized clinical trial was conducted from December 2016 March 2018 cancer who received thoracoscopic lobectomy West China Hospital, Daping Sichuan Cancer Hospital. To further 2 procedures, we reviewed Western Lung database (2005-2017)...
In this study, we aimed to elucidate the biological roles of Syndecan-2 (SDC2) in colorectal cancer (CRC), thereby further understanding its clinical role. The expression SDC2 was assessed by qRT-PCR and Western blot analysis. To understand potential role SDC2, also explored correlation between level clinicopathologic parameters. By using MTT, plate colony formation assay, Transwell invasion assays, flow cytometry vitro, impact on CRC cell proliferation, migration, invasion, apoptosis....
Traditional thoracic ultrasound (TUS) is often the initial tool used to help diagnose malignant pleural effusion (MPE). Ultrasound elastography, a relatively new technique, has been differentiate disease from benign by evaluating tissue "stiffness". However, no studies efficacy of elastography for diagnosing MPE are available. We assessed value elsatography prospectively.All 244 enrolled patients were divided into development set and validation in chronological order. The cut-off elasticity...
Chaperonin containing TCP1 subunit 7 (CCT7) regulates the expression of many tumor-related proteins. We investigated diagnostic and prognostic value CCT7 for hepatocellular carcinoma (HCC). In datasets from The Cancer Genome Atlas Gene Expression Omnibus, mRNA levels were greater in HCC tissues than adjacent normal tissues, these results validated using immunohistochemistry. patients with early-stage disease low alpha-fetoprotein expression, was still higher tissues. Receiver operating...
Peripheral mechanical neuropathic pain is a serious side effect of docetaxel chemotherapy for cancer. However, the underlying mechanism this unknown. In present study, we found that treatment induced allodynia in rats. We further revealed transient receptor potential ankyrin subtype 1 protein (TRPA1) level upregulated and TRPA1 activator allyl isothiocyanate larger ion currents dorsal root ganglion neurons from treated addition, application blocker Ap18 reversed docetaxel‐induced...
We investigated the roles of breast cancer anti-estrogen resistance 1 (BCAR1/p130Cas) in formation and immunoevasion invasive circulating tumor cells (CTCs) lung adenocarcinoma (LUAD).
Abstract Background Melanoma is an aggressive disease that rising in incidence. Advanced melanoma still a life‐threatening disease. CircRNAs are documented to be involved progression. But circITCH role remains unclear. Methods and Results To explore the functions of melanoma, levels tissues paracarcinoma normal were detected. study roles terms cell proliferation migration, vitro vivo experiments performed. Mechanism was designed investigate potential regulatory effect melanoma. revealed...
To determine the efficacy of post-operative chemotherapy with cisplatin plus vinorelbine (NP) in Chinese patients non-small cell lung cancer (NSCLC).A total 451 NSCLCs at stages I, II, and IIIA after surgical resection were treated for 4 cycles or volunteers observed between January 2002 November 2004 followed five years. The therapeutic was evaluated reference to overall survival (OS) disease-free (DFS), adverse effects also recorded. Potential factors affecting lengths OS DFS analyzed by...
To assess the efficacy of radical surgery combined with recombinant adenoviral human p53 (rAd-p53) gene therapy in treatment resectable non-small cell lung cancer.A total 163 patients NSCLC meeting inclusion criteria were randomly assigned to two groups: alone (S) and plus surgical wound surface injection 2 x 1012 rAd-p53 units (SP). All followed up for at least 3 years safety. Study endpoints loco-regional recurrence or distant metastasis (Rec-Met) rate as primary endpoints, progression...
Background: The Hippo pathway's primary kinase component, large tumor suppressor 1 (LATS1), has been hypothesized as a in variety of cancers. LATS1's biological effects on colorectal cancer (CRC) are yet to be determined. Methods: analysis LATS1 mRNA expression CRC was conducted using public databases from the Gene Expressing Profiling Interactive Analysis database (GEPIA). Investigation for protein 102 tissues and 57 normal performed immunohistochemistry (IHC) analysis. In vitro genetic...
OBJECTIVE To explore the association between metabolic syndrome (MS) and risk of cardiovascular disease events (CVD) in patients with ischemic stroke. METHOD A total 1087 stroke were enrolled from 5 community-based medical centres underwent baseline evaluation on factors during period Jan. 2003 to Dec. 2006. After survey, all followed up until Dec 31, 2008 new CVD recorded. MS was defined using CDS criteria. Proportional hazard models used assess HRs 95% CI associated other components....
Circulating tumor cells with epithelial-mesenchymal transition markers as potential biomarkers for the diagnosis of lung cancer
Borderline ovarian tumor (BOT) refers to a distinct of the ovary epithelial origin and typically has favorable prognosis. However, these tumors are not exempt from risks recurrence malignant transformation, which can arise remaining tissue, peritoneal implants or distant localization. Here, we report case mucinous BOT with multiple pulmonary cystic nodules without evidence metastasis even after two fine needle biopsies. Cytoreductive surgery was performed, no invasion adjacent organs found....
S-phase kinase-associated protein 2 (Skp2) is one of the positive regulators cell cycle that promote Ubiquitin-mediated proteolysis cyclin-dependent kinase inhibitor p27. Its overexpression has been implicated in tumorigenesis. In this study, we investigated expression Skp2 human nonsmall lung cancer (NSCLC) and its relationship with p27 protein.The were detected 68 NSCLC, 17 normal bronchial epithelium by tissue chip immunohistochemistry technology.Skp2 was only expressed NSCLC patients,...
Objective: To clarify the clinical significance of breast cancer anti-estrogen resistance protein 1 (BCAR1) expression in circulating tumor cells (CTCs) peripheral blood and tissues patients with early stage lung adenocarcinoma (ES-LUAD). Methods: The study cohort included 60 I LUAD (50 IA 10 IB) who underwent surgery from November 2015 to 2018 31 healthy controls. levels BCAR1 markers epithelial-mesenchymal transition (EMT) CTCs were detected using CanPatrol TM technology before surgery,...
The three-dimensional (3D) saddle shape of the mitral annulus (MA) is well characterized in humans, but segmental MA deformity and regurgitation suffered after ischemic damage myocardial infarction (MI) poorly understood. In this study, such changes were assessed patients with (IMR) post-MI, using our computerized 3D echo technique.A patient cohort (n = 72) IMR due to inferior or anterior MI normal controls 20) enrolled for studies. Sequential coordinates manually measured from each 18...
The aberrant metabolism of fatty acids is recognized as a key driver in the development and progression tumors. Although numerous inhibitors have been developed to target this pathway, finding drugs with high specificity that do not disrupt normal cellular remains formidable challenge. In manuscript, we introduced novel real-time NMR-based drug screening technique operates within living cells. This provides direct way putatively identify molecular targets involved specific metabolic...