A5101534900- Cellular Mechanics and Interactions
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Cell Image Analysis Techniques
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
Harbin Medical University
2021-2023
First Affiliated Hospital of Harbin Medical University
2021-2023
Wuhan University of Science and Technology
2018-2022
The characteristic of carcinoma is cell migration and invasion, which involve in strong actin dynamics. Regulations dynamics have been implicated cancer tumor progression. WDR1 (WD-repeat domain 1) a major cofactor the depolymerizing factor (ADF)/cofilin, strongly accelerating ADF/cofilin-mediated disassembly. role non-small lung (NSCLC) progression has unknown. Here, we show that expression levels are increased human NSCLC tissues compared with adjacent non-tumor tissues, high level...
As a major co-factor of F-actin depolymerization, WD-repeat domain 1 (WDR1) affects the cellular microenvironment by cytoskeleton remodeling, thereby influencing cell molecular behavior. Our previous study showed that WDR1 activates YAP (Yes-associated protein) signaling in non-small-cell lung cancer (NSCLC) cells, but mechanism remains unclear. We discovered knockdown NSCLC cells decreased expression and nucleus-to-cytoplasm ratio. Disruption cortical stress drugs significantly inhibited...
The migration, dedifferentiation, and proliferation of vascular smooth muscle cells (VSMCs) are responsible for intimal hyperplasia, but the mechanism this process has not been elucidated. WD repeat domain 1 (WDR1) promotes actin-depolymerizing factor (ADF)/cofilin-mediated depolymerization actin filaments (F-actin). role WDR1 in neointima formation progression is still unknown. A model thickening was constructed by ligating left common carotid artery
Abstract Pancreatic cancer is a malignant tumor of the digestive tract with poor prognosis. Dual-specificity phosphatase 2 (DUSP2) member mitogen-activated protein kinase family that involved in multiple pathophysiological processes. However, its role pancreatic remains further investigation. The most prominent feature hypoxic microenvironment, which plays an important progression, drug resistance, and immune evasion. Therefore, we explored DUSP2 by simulating such microenvironment found...