A5103029167- Advanced Fiber Laser Technologies
- Photonic Crystal and Fiber Optics
- Laser-Matter Interactions and Applications
- Advanced Fiber Optic Sensors
- Lymphoma Diagnosis and Treatment
- Photonic and Optical Devices
- Orbital Angular Momentum in Optics
- Optical Network Technologies
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Random lasers and scattering media
- Mechanical and Optical Resonators
- Laser-Plasma Interactions and Diagnostics
- Acute Ischemic Stroke Management
- Laser Design and Applications
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Optical Coherence Tomography Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Lung Cancer Treatments and Mutations
- Digital Holography and Microscopy
- Neurological Disease Mechanisms and Treatments
- Advanced MEMS and NEMS Technologies
Shanghai Institute of Optics and Fine Mechanics
2022-2025
Chinese Academy of Sciences
2022-2024
University of Chinese Academy of Sciences
2022-2024
Hong Kong Polytechnic University
2024
University of Science and Technology of China
2023-2024
State Key Laboratory of High Field Laser Physics
2024
Instituto de Óptica "Daza de Valdés"
2024
Weifang Medical University
2022-2023
Peking University
2018-2021
Peking University Third Hospital
2018-2021
We observed narrow-linewidth lasing spikes in a coherent Brillouin random fiber laser, which uses continuous-wave laser as the pump source. In this configuration, stimulated scattering section of conventional single-mode acts gain mechanism, while Rayleigh another nonuniform provides randomly distributed feedback. Above threshold, spikes, with linewidth ~10 Hz, are measured at top spectrum. It results from high quality resonance Stokes light open cavity.
We report a single frequency lasing phenomenon with narrow linewidth of ~3 kHz in cascaded fiber that is composed three types low-loss communication fibers. The Rayleigh scattering the Brillouin Stokes light created middle section along both directions enhanced by other two sections. When gain exceeds effective loss stokes roundtrip, observed on top spectrum line fiber. To best our knowledge, it first scattering-assisted and
A coherent random fiber laser based on stimulated Brillouin scattering as gain and Rayleigh distributed feedback mirror was constructed. Its frequency is stabilized by a high finesse narrow-band Fabry-Perot interferometer (FPI) to select lasing within the bandwidth. The light confinement single-mode enhances largely directionality, which enables high-quality in weak region using milliwatt continuous-wave pump source. FPI configuration acts selection light, thus locked at one of its...
Abstract Continuous-wave mode-locking at multi-GHz repetition rates is achieved in an ultrashort laser cavity critical pulse energies 100 times lower than predicted by conventional theory. The authors reveal that dynamic gain depletion and recovery between consecutive round-trips the key factor behind a low-pulse-energy transition from Q-switched (QSML) to continuous-wave (CWML). As well as providing new insight into dynamics, results suggest practical route low-threshold lasing very...
Stimulated Brillouin scattering (SBS) in gas-filled hollow-core fibers (HCFs) provides high gain and narrow linewidth, making it a promising platform for advanced photonic applications. While is known to depend quadratically on pressure linewidth inversely pressure, the combined effect of temperature - through their influence gas density-has not been fully explored. In this study, we demonstrate that lowering from 373.15 K 233.15 at 100 bars (using nitrogen) leads six-fold increase twofold...
High quality free-space and over-fibre transmission of mid-IR light is limited by factors such as material-related absorption, diffraction, leakage nonlinearity. Conventional vacuum apparatus can be utilized for high-quality laser-beam delivery to address these issues, the deployment would, however, increase system complexity, being detrimental their practical applications. Here we report successful use evacuated hollow-core photonic crystal fibre (PCF) flexibly transmit ultrafast pulses...
We present the flexible delivery of picosecond laser pulses with up to 20 W average power over a 3-m-long sample anti-resonant hollow-core fiber (AR-HCF) for micromachining applications. Our experiments highlight importance optical mode purity AR-HCF manufacturing precision. demonstrate that compared an capillary core (d/D) ratio ~0.5, d/D ~0.68 exhibits better capability high-order-mode suppression, giving rise improved quality. Moreover, system pointing stability and set-up flexibility...
We demonstrate that by using a 1-m-long gas-filled hollow capillary fiber (HCF) with core diameter of 100 μm, tunable ultraviolet (UV) dispersive-wave (DW) pulses can be generated in compact, single-stage setup driven directly 40-fs Ti:sapphire laser pulses. By adjusting the gas type and pressure inside HCF, central wavelength UV DW continuously tuned from 185 nm to ∼450 nm. In experiment, we found for ∼320-450 generation, Raman-active filled HCF efficiently suppress pulse fission effect...
We report a mid-infrared (mid-IR) fiber laser system that can deliver ultrafast soliton-like pulses with wavelength tunable from 2.8 to 4.0 μm. The pump light source of the is mid-IR mode-locked at μm, which has an average output power ∼500 mW, repetition rate ∼30 MHz, pulse energy ∼15 nJ, and duration ∼150 fs. was then launched into short (∼70 cm) sample fluorotellurite (TeO2-BaF2-Y2O3) glass as high-nonlinearity waveguide simultaneously good features large Raman gain, tailored dispersion,...
Abstract Background Although R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) remains the standard chemotherapy regimen for diffuse large B cell lymphoma (DLBCL) patients, not all patients are responsive to scheme, there is no effective method predict treatment response. Methods We utilized 5hmC-Seal generate genome-wide 5hmC profiles in plasma cell-free DNA (cfDNA) from 86 DLBCL before they received chemotherapy. To investigate correlation between modifications...
We demonstrate the stable and flexible light delivery of multi-microjoule, sub-200-fs pulses over a ∼10-m-long vacuumized anti-resonant hollow-core fiber (AR-HCF), which was successfully used for high-performance pulse synchronization. Compared with train launched into AR-HCF, transmitted out exhibits excellent stabilities in power spectrum, pointing stability largely improved. The walk-off between fiber-delivery other free-space-propagation trains, an open loop, measured to be <6 fs root...
In ischemia-reperfusion stroke, microglia play a dual role in brain injury as well repair, and promoting their switch from pro-inflammatory M1 phenotype to an anti-inflammatory M2 is considered be potential therapeutic strategy. Docosahexaenoic acid (DHA) essential long-chain omega-3 polyunsaturated fatty that exhibits potent properties the acute phase of ischemic but its effect on polarization unknown. Thus, objective this study was investigate neuroprotective effects DHA rat following...
Background: The presence of circulating plasma cells (cPCs) was associated with a worse prognosis in multiple myeloma patients. However, the underlying mechanisms involved migration and invasion bone marrow (BMMCs) to cPCs remains unclear. Here, we investigate possible factors related hematogenous cell dissemination potential regulatory mechanisms. Methods: BMMCs five extramedullary plasmacytoma (EMP) patients were selected for single RNA sequencing, We found that expression level...
Abstract Brillouin scattering has been widely exploited for advanced photonics functionalities such as microwave photonics, signal processing, sensing, lasing, and more recently in micro- nano-photonic waveguides. Most of the works have focused on opto-acoustic interaction driven from core region nano-waveguides. Here we observe, first time, an efficient generated by evanescent field nearby a single-pass sub-wavelength waveguide embedded pressurised gas cell, with maximum gain coefficient...
High-energy ultraviolet pulse generation in gas-filled hollow capillary fibers (HCFs) through dispersive-wave-emission process, has attracted considerable attentions recent several years due to its great application potentials spectroscopy and photochemistry. While the ability of this technique deliver high-energy, ultrafast pulses is widely recognized, few-fs duration {\mu}J-level dispersive-wave (DW) has, however, escaped direct measurements. In letter, we demonstrate that using chirped...
N6‑methyladenosine (m6A) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are to serve crucial roles in metabolism. However, role of m6A during B‑cell development tumorigenesis remains poorly understood. By analyzing gene expression profile 123 mantle cell lymphoma cases from Gene Expression Omnibus database, present study demonstrated that one‑half were able predict patient survival lymphoma, notably m6A.index....
The brain injury caused by cerebral ischemia-reperfusion is related to mitochondrial damage. Maintaining the normal function of mitochondria, promoting angiogenesis, protecting neuronal cells, and resisting oxidative stress are keys functional recovery after acute ischemic stroke. In this study, we established a middle artery occlusion (MCAO) model investigated effects 1α,25-dihydroxyvitamin D3 (VitD or 1,25-D3) on via adenosine 5'-monophosphate-activated protein kinase (AMPK)/protein B...
Abstract Femtosecond light pulses carrying optical angular momentums (OAMs), possessing intriguing properties of helical phase fronts and ultrafast temporal profiles, enable many applications in nonlinear optics, strong‐field physics, laser micromachining. While generation OAM‐carrying their interactions with matters are intensively studied experiments, 3D characterization beams spatiotemporal domain has, however, proved difficult to achieve. Conventional measurement schemes rely on the use...