A5039773936- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Agricultural Engineering and Mechanization
- Diet, Metabolism, and Disease
- Soil Mechanics and Vehicle Dynamics
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Periodontal Regeneration and Treatments
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Pancreatic and Hepatic Oncology Research
- Cryospheric studies and observations
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Advanced Glycation End Products research
Changhai Hospital
2024
Second Military Medical University
2024
Shanghai University of Traditional Chinese Medicine
2008-2023
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2008-2023
Huazhong Agricultural University
2015-2023
China-Japan Friendship Hospital
2023
Beijing Normal University
2006-2022
Shandong First Medical University
2021
Shandong University
2020-2021
University Medical Center Groningen
2018-2021
// Ming Zhou 1,* , Lei Wang Songqin Zhao 1 Juncheng Ruan Lijun Tang 3 Ziming Jia Min Cui Ling and Zhen F. Fu 1,2 State Key Laboratory of Agricultural Microbiology, College Veterinary Medicine, Huazhong University, Wuhan, China 2 Department Pathology, University Georgia, Athens, GA, USA Hubei Provincial for Applied Toxicology, Academy Preventive * These authors have contributed equally to this paper Correspondence to: Zhao, email: Fu, Keywords : rabies, recombinant rabies virus, GM-CSF, oral...
Antibodies (Abs) have been engineered into small antigen‐binding fragments and rebuilt multivalent high‐avidity molecules for improving in vivo pharmacokinetics efficacy clinical use. To increase the avidity of a T‐cell receptor‐like single‐domain Ab (sdAb) specific HLA‐A2 complex, we fused sdAb to coiled‐coil peptide derived from human cartilage oligomeric matrix protein (COMP48) make an multimer, termed combody. The combody improved binding significantly, whereas specificity targeted cells...
The pneumatic precision seed-metering devices used in combination with negative air pressure to suck seed and positive flow drop could overcome the problem of rapeseed planting. However, these can only plant a single row at time or need high airflow pressure, which complicates system seeder structure, deteriorate working reliability have power consumption. To above shortcomings, novel prototype centralized device inside-filling, sowing six rows time, was developed. main structure principle...
Following transplantation, patients must take immunosuppressive medication for life. Torquetenovirus (TTV) is thought to be marker immunosuppression, and TTV-DNA levels after organ transplantation have been investigated, showing high TTV levels, associated with increased risk of infections, low rejection. However, this has investigated in studies relatively short follow-up periods. We hypothesized that can used assess long term outcomes renal transplantation. Serum samples 666 transplant...
Blastocystis hominis (Bh) is zoonotic parasitic pathogen with a high prevalent globally, causing opportunistic infections and diarrhea disease. Human immunodeficiency virus (HIV) infection disrupts the immune system by depleting CD4+ T lymphocyte (CD4+ T) cell counts, thereby increasing Bh risk among persons living HIV (PLWH). However, precise association between HIV-related biological markers treatment processes remains poorly understood. Hence, purpose of study was to explore viral load...
Isogarcinol is a new natural immunosuppressant that was extracted from Garcinia mangostana L. in our laboratory. Knowledge of its effects on treatable diseases and mechanism action still very limited. In this study, we explored the therapeutic effect isogarcinol experimental autoimmune encephalomyelitis (EAE), murine model multiple sclerosis (MS). Treatment with oral 100 mg/kg markedly ameliorated clinical scores, alleviated inflammation demyelination spinal cord, reduced intracranial...
Porcine parvovirus (PPV) is the most important infectious agent causing infertility in pigs, which can be prevented by routine vaccination. Successful vaccination depends on association with potent adjuvants that enhance immunogenicity of antigen and activate immune system. Polysaccharide adjuvant has low toxicity high safety, they humoral, cellular mucosal responses. In present study, we prepared VP2 protein subunit vaccine against PPV (PPV/VP2/N-2-HACC) using water-soluble...
Obesity, characterized by the excessive accumulation of triglycerides in adipocytes and their decreased excretion from adipocytes, is closely related to various health problems. Ginsenoside Rb1 (Rb1), most active component traditional Chinese medicine ginseng, has been reported have positive effects on lipid metabolism. The aim present study was determine protective glycolipid metabolism under obesity conditions its mechanisms reveal signaling pathways involved.In our study, male C57BL/6...
In recent years, the incidence of herpes zoster has risen steeply, exact pathogenesis acute pain and transformation into postherpetic neuralgia are still obscure, absence effective management remains a major therapeutic challenge. The purpose this study was to perform qualitative quantitative bibliometric analysis 100 most cited papers on zoster. Related literature were retrieved from Web Science Core Collection. Excel VOSviewer software applied quantitatively analyze, construct network...
Objective: To investigate the clinical effects and security of YiSuiShengXueGranule (YSSXG) on treating 156 patients with β-thalassemia major. Methods: YSSXG was given orally to in GuangXi Autonomous Region (the high incidence area China) for 3 months as one therapeutic course, times a day, 10 g each time (for children, dose should be reduced properly according their body weight age), no blood transfusion used during course. Clinical symptoms levels hemoglobin (Hb), red cell (RBC),...
Abstract Background Stomach is an integral part of the energy balance regulating circuit. Studies exploring effects cross-system changes in homeostasis stomach tissue are scarce. The proximity to liver - most common secondary target affected by obesity – suggests that these two organs exposed each other’s local secretion. Therefore, we aimed at expression profiling metabolism associated genes gastric obese non-alcoholic fatty disease (NAFLD) patients. Methods A total 24 patients with...
BACKGROUNDHerpes zoster (HZ) is caused by the reactivation of varicella–zoster virus (VZV). Patients with lung transplants are at high risk for HZ owing to their immunocompromised status and need lifelong immunosuppression. In this study, patients on waiting list transplantation were vaccinated a live-attenuated vaccine (Zostavax, Merck Sharp & Dohme), safety immunogenicity studied.METHODSIn total, 105 end-stage pulmonary disease (ESPD) enrolled (68 participants received 1 dose Zostavax 37...
OBJECTIVE: 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) was one of the newly found lipokines. The goal this study to investigate whether 12,13-diHOME associated with related metabolic markers nonalcoholic fatty liver disease (NAFLD) in a Chinese population type 2 diabetes (T2DM) and obesity.METHODS: This cross-sectional enrolled 202 subjects T2DM. Anthropometric parameters, 12,13-diHOME, serum lipids levels, fasting blood-glucose (FBG), glycosylated hemoglobin (HbA1c), insulin (FINS),...
The main goal of this study was to design a pneumatic cylindrical-type metering device with six-rows for wheat precision and analyze its output under different rotating speeds vacuum pressure values. effect the pressure, speed rows on seed suction, retention dropping shown inspected. Six levels (5, 10, 15, 20, 25 30 r/min.) combined applying pressures (1.8, 2.1, 2.4, 2.7, 3.0, 3.3 kPa) were inspected detect optimum which adequate sucking at each speed. In addition, predict corresponding...
Herpes zoster (HZ) risk is high in renal transplant recipients. Vaccination prior to transplantation may provide a useful strategy for the prevention of HZ posttranplantation period. However, it not known whether immunity varicella-zoster virus (VZV) affected due treatment surrounding transplantation.Both humoral and cellular VZV were determined 2-3 years after 60 adult patients, 62 matched healthy controls. VZV-specific was measured by an interferon gamma (IFNγ) enzyme-linked immunospot...
The mean age of lung transplant recipients has significantly increased in recent decades. Elderly have a higher risk developing herpes zoster (HZ), and they general worse response to vaccination than younger persons do. We investigated the relationship between humoral cellular immune live-attenuated HZ vaccine (Zostavax®, Merck Sharp Dohme) frequencies T B cell subsets, especially aged subsets (CD28−T cells associated cells, ABCs). In total, 37 patients awaiting transplantation received one...