A5050727273- Cystic Fibrosis Research Advances
- Sinusitis and nasal conditions
- Neonatal Respiratory Health Research
- Tuberculosis Research and Epidemiology
- Asthma and respiratory diseases
- Congenital Ear and Nasal Anomalies
- Mycobacterium research and diagnosis
- Bacterial biofilms and quorum sensing
- Immune Cell Function and Interaction
- Olfactory and Sensory Function Studies
- Tracheal and airway disorders
- IL-33, ST2, and ILC Pathways
- Head and Neck Surgical Oncology
- Viral Infections and Immunology Research
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Antibiotic Resistance in Bacteria
- Nonlinear Differential Equations Analysis
- Obstructive Sleep Apnea Research
- Pediatric health and respiratory diseases
- Differential Equations and Boundary Problems
- Ginseng Biological Effects and Applications
- Pneumonia and Respiratory Infections
- Antiplatelet Therapy and Cardiovascular Diseases
- Diagnosis and treatment of tuberculosis
University of Alabama at Birmingham
2014-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2017-2025
Shanghai University of Traditional Chinese Medicine
2017-2025
Jilin Normal University
2024
Henan Forestry Vocational College
2024
Fuzhou University
2023
Shenzhen Institutes of Advanced Technology
2021
Chinese Academy of Sciences
2021
Tongji University
2020
Shanghai Pulmonary Hospital
2020
Abstract Background The co-infection of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) and tuberculosis (TB) poses a significant clinical challenge is major global public health issue. This study aims to elucidate the disease burden HIV-TB in global, regions countries, providing critical information for policy decisions curb epidemic. Methods ecological time-series used data from Global Burden Disease (GBD) Study 2021. encompass numbers incidence, prevalence,...
Pseudomonas aeruginosa is frequently implicated in difficult-to-treat infectious cases due to its resistance conventional antibiotics and ability form biofilms [1, 2]. To avoid limitations of systemic antibiotic drug delivery, our previous studies explored the feasibility a localized treatment approach using novel ciprofloxacin azithromycin sinus stent (CASS) treat sinusitis [3, 4]. It double-layered, with an inner hydrophilic outer hydrophobic azithromycin. This double-layered coating...
Dehydration of airway surface liquid (ASL) disrupts normal mucociliary clearance in sinonasal epithelium leading to chronic rhinosinusitis. Abnormal chloride (Cl(-)) transport is one mechanism that contributes this disorder, as demonstrated by the disease cystic fibrosis. Identifying safe compounds stimulate transepithelial Cl(-) critical improving hydration ASL and promoting transport. Sinupret (Bionorica, LLC, San Clemente, CA), a combination naturally occurring bioflavonoids, widely used...
The cystic fibrosis transmembrane conductance regulator (CFTR) serves as a predominant Cl(-) transport conduit in airway epithelium and is inhibited by cigarette smoke vitro vivo. Activation of secondary pathways through calcium-activated channels (CaCC) has been postulated mechanism to bypass defects CFTR-mediated transport. Because it not known whether CaCCs are also tobacco exposure, the current study was designed investigate effect condensate (CSC) on CaCC transport.In...
Objectives/Hypothesis: Sinonasal respiratory epithelial mucociliary clearance is dependent on the transepithelial transport of ions such as Cl−. The objectives present study were to investigate role oxygen restriction in 1) Cl− across primary sinonasal monolayers, 2) expression apical channels cystic fibrosis transmembrane conductance regulator (CFTR) and protein 16A (TMEM16A), 3) pathogenesis chronic rhinosinusitis. Study Design: In vitro investigation. Methods: Murine nasal septal (MNSE),...
Methods to improve the clinical efficacy of currently available antibiotics against multidrug resistant bacteria in cystic fibrosis (CF) chronic rhinosinusitis (CRS) are greatly needed. Ivacaftor, a transmembrane conductance regulator potentiator, was recently identified as having potentially beneficial off-target effects weak inhibitor bacterial DNA gyrase and topoisomerase IV. The objective current study is evaluate whether ivacaftor enhances antimicrobial activity ciprofloxacin...
Abstract Background China is the second highest pulmonary tuberculosis (PTB) burden country worldwide. However, retreatment of PTB has often developed resistance to at least one four first-line anti-TB drugs. The cure rate (approximately 50.0–73.3%) and management in needs be improved. Qinbudan decoction been widely used treat since 1960s. Previously clinical studies have shown that tablet (QBDT) promoted sputum-culture negative conversion lesion absorption. powerful evidence from a...
Abstract Background The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a significant number of mortalities worldwide. COVID-19 poses serious threat human life. clinical manifestations are diverse and 20% infected patients reported be in critical condition. A loss lung function pulmonary fibrosis the main with form disease. is affected, even after recovery, thereby greatly affecting psychology well-being patients,...
Abstract Objective/Hypothesis: Therapeutic agents that enhance mucociliary transport (via stimulation of transepithelial Cl − secretion) and inhibit inflammation could provide considerable advantages over conventional treatments for chronic rhinosinusitis (CRS). The objectives the present study were to investigate whether polyphenolic compound resveratrol promotes inhibits KC/IL‐8 secretion in sinonasal epithelium. Study Design: In vitro vivo study. Methods: Transepithelial was investigated...
The emergence of clarithromycin resistance is a challenge in treating Mycobacterium abscessus infections. Known mechanisms that contribute to intrinsic focus on rrl gene-related mutations, but resistant clinical isolates often exhibit an inconsistent genotype.In this study, 194 were collected from patients with lung infections and the whole genome each isolate was sequenced. A comprehensive examination molecular underlying performed, combining MIC determination, comparative sequence analysis...
Pharmacologic agents designed to promote mucociliary clearance (MCC) in chronic rhinosinusitis (CRS) represent a novel therapeutic strategy. The objectives of the present study were investigate whether natural bioflavonoid hesperidin 1) increases transepithelial chloride (Cl(-)) secretion vitro and vivo, 2) enhances ciliary beat frequency (CBF), 3) exerts its mechanistic effects through cAMP/PKA-dependent pathways.In vivo study.Laboratory.Transepithelial Cl(-) transport (Ussing chamber) CBF...
IMPORTANCE Pharmacologic activation of mucociliary clearance (MCC) represents an emerging therapeutic strategy for patients with chronic rhinosinusitis, even in the absence congenital mutations CFTR gene.Drug discovery efforts have identified small molecules that activate cystic fibrosis transmembrane conductance regulator (CFTR), including potentiators under development treatment fibrosis.OBJECTIVE To evaluate properties modulators and their effects on ciliary beat frequency (CBF) human...
Enhancing chloride (Cl- ) secretion in sinus epithelia represents a novel therapeutic approach to chronic rhinosinusitis (CRS). Herbal dry extract BNO 1011 enhances mucociliary clearance (MCC) via upregulation of Cl- sinonasal cultures vitro and murine epithelium vivo. The objective this study is evaluate whether the improves MCC clinical parameters rabbit model CRS.After development CRS 30 New Zealand white rabbits, animals were randomly assigned receive oral placebo (n = 10), (low dose...
Background Chronic rhinosinusitis (CRS) is a chronic inflammatory disease characterized by persistent inflammation and bacterial infection. Ciprofloxacin azithromycin are commonly prescribed antibiotics for CRS, but the ability to provide targeted release in sinuses could mitigate side effects improve drug concentrations at infected site. This study was aimed evaluate efficacy of novel ciprofloxacin‐azithromycin sinus stent (CASS) vitro. Methods The CASS created coating ciprofloxacin...
Background We recently developed a novel ciprofloxacin‐coated sinus stent capable of releasing antibiotics over sustained period time. Ivacaftor is cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that has synergistic bactericidal activity with ciprofloxacin and also enhances mucociliary clearance. The objective this study was to optimize evaluate the efficacy ciprofloxacin‐ ivacaftor‐releasing biodegradable (CISS) in vitro. Methods A CISS created by coating...
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result defective Cl- transport and cause chronic bacterial infections upper lower airways of (CF) patients. Ivacaftor is a CFTR potentiator that improves CF patients with at least 1 copy G551D mutation. Resveratrol also potent increases determinants mucociliary transport. The objective this study to determine whether resveratrol ivacaftor improve secretion over either agent alone.Fisher rat thyroid cells (FRT)...
As China is one of high MDR-TB burden countries, it important to determine the drug resistant pattern and clinical characteristics multidrug tuberculosis (MDR-TB). We conducted a comprehensive nationwide study on in 17 provinces for period from June 2009 2015, total 1154 cases were finally investigated. The sought assess features contrast susceptibility profiles patients China. Cavitary disease, young age, long duration TB disease among predictors. A resistance proportion first-line drugs...
Therapeutic options for Mycobacterium abscessus infections are extremely limited. New or repurposed drugs needed. The anti-M. activity of AR-12 (OSU-03012), reported to express broad-spectrum antimicrobial effects, was investigated in vitro and vivo Antimicrobial susceptibility testing performed on 194 clinical isolates. Minimum bactericidal concentration time-kill kinetics assays were conducted distinguish the versus bacteriostatic AR-12. Synergy between five clinically important...
Objectives Previously, we developed a novel double‐coated sinus stent containing ciprofloxacin (inner layer) and azithromycin (outer (CASS), but released drug concentrations were found to be insufficient for clinical usage. Our objectives are improve release of CASS assess safety pharmacokinetics in rabbits. Methods Dip coating was used create the with 2 mg 5 azithromycin. A uniformed double assessed scanning electron microscopy (SEM), patterns both drugs lactate dehydrogenase (LDH) assay...
Abstract Chronic intermittent hypoxia (CIH) in obstructive sleep apnea causes damage of aortic endothelial cells, which predisposes the development many cardiovascular diseases. Recently, both altered expression microRNAs (miRNAs) and impaired autophagy were found to be associated with cell dysfunction CIH. However, exact molecular regulatory pathway has not been determined. Here, we address this question. In a mouse model CIH, detected significant upregulation miR‐30a, miRNA that targets...