A5036733807- Sinusitis and nasal conditions
- Cystic Fibrosis Research Advances
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Allergic Rhinitis and Sensitization
- Neonatal Respiratory Health Research
- Bacterial biofilms and quorum sensing
- Congenital Ear and Nasal Anomalies
- Oral and Maxillofacial Pathology
- Neurosurgical Procedures and Complications
- Oral microbiology and periodontitis research
- Craniofacial Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Dysphagia Assessment and Management
- Obstructive Sleep Apnea Research
- Pediatric health and respiratory diseases
- Olfactory and Sensory Function Studies
- Bone Tumor Diagnosis and Treatments
- Meningioma and schwannoma management
- Pneumonia and Respiratory Infections
- Oral and gingival health research
- Facial Trauma and Fracture Management
- Hearing, Cochlea, Tinnitus, Genetics
University of Alabama at Birmingham
2016-2025
Birmingham VA Medical Center
2020-2025
University of Alabama
2016-2025
Cystic Fibrosis Foundation
2020-2022
Konyang University
2017
Stanford University
2008-2014
Sungkyunkwan University
2001-2007
Samsung Medical Center
2001-2007
China Medical University Hospital
1997
China Medical University
1997
Background In patients with chronically diseased maxillary sinuses, poor mucociliary clearance may result from long-standing inflammation or scarring previous surgery. This subset of often has persistent sinus disease despite medical therapy and adequate antrostomy. Endoscopic mega-antrostomy (EMMA) is a mucosal sparing technique that facilitates mucus irrigation in terminally dysfunctional sinuses. EMMA involves extending the antrostomy through posterior half inferior turbinate down to...
Background Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that improves pulmonary function in (CF) patients with at least 1 copy of the G551D CFTR mutation. The purpose this study to evaluate impact ivacaftor on chronic rhinosinusitis (CRS) symptoms population. Methods Observational (GOAL) was multicenter prospective cohort enrolling CF ≥6 years Subjects were provided 20‐item Sino‐Nasal Outcome Test (SNOT‐20) questionnaires prior therapy and 1, 3, 6...
Management of frontal sinus trauma includes coronal or direct open approaches through skin incisions to either ablate obliterate the for posterior table fractures and openly reduce/internally fixate fractured anterior tables. The objective this prospective case-series study was evaluate outcomes using endoscopic techniques.Prospective evaluation patients undergoing surgery performed. Data were collected regarding demographics, etiology, technique, operative site, length involving table, size...
Background The Draf III procedure is an effective endoscopic approach to the treatment of frontal sinus disorders, but has a significant restenosis rate. objective current study assess long‐term success mucosal grafting technique. Methods Patients undergoing with technique were prospectively enrolled. Demographics, indication for surgery, anterior‐posterior (AP) diameter ostium, and complications recorded. Failure was defined priori as closure ≥50% intraoperative AP at last clinical...
Micro-optical coherence tomography with an intranasal imaging probe detects defects in the mucociliary transport of people cystic fibrosis.
Pseudomonas aeruginosa is frequently implicated in difficult-to-treat infectious cases due to its resistance conventional antibiotics and ability form biofilms [1, 2]. To avoid limitations of systemic antibiotic drug delivery, our previous studies explored the feasibility a localized treatment approach using novel ciprofloxacin azithromycin sinus stent (CASS) treat sinusitis [3, 4]. It double-layered, with an inner hydrophilic outer hydrophobic azithromycin. This double-layered coating...
Abstract Objective Cystic fibrosis (CF) is a clinical entity defined by aberrant chloride (Cl − ) ion transport causing downstream effects on mucociliary clearance (MCC) in sinonasal epithelia. Inducible deficiencies transepithelial Cl via CF transmembrane conductance regulator (CFTR) has been theorized to be driving process recalcitrant chronic rhinosinusitis (CRS) patients without CF. We have previously identified that brief exposures bacterial lipopolysaccharide (LPS) mammalian cells...
Methods to improve the clinical efficacy of currently available antibiotics against multidrug resistant bacteria in cystic fibrosis (CF) chronic rhinosinusitis (CRS) are greatly needed. Ivacaftor, a transmembrane conductance regulator potentiator, was recently identified as having potentially beneficial off-target effects weak inhibitor bacterial DNA gyrase and topoisomerase IV. The objective current study is evaluate whether ivacaftor enhances antimicrobial activity ciprofloxacin...
Background: Rabbits are useful for preclinical studies of sinusitis because similar physiologic features to humans. The objective this study is develop a rabbit model that permits assessment microanatomy and sampling evaluating shifts in the sinus microbiota during development test how mucociliary clearance (MCC) defect might lead dysbiosis chronic rhinosinusitis (CRS). Methods: Generation CRS was accomplished with an insertion sterile sponge into left middle meatus New Zealand white rabbits...
Abstract Conclusion These findings suggest that patients with both sinusitis and asthma present the histopathologic characteristic of a marked chronic inflammatory reaction, eosinophil infiltration may play significant role in this inflammation sinus mucosa. Objective Chronic bronchial are known to be closely related. However, appearance mucosa is somewhat different from without asthma. Material methods We compared mucosal histopathologies asthmatic those non-asthmatic patients. Fifty-three...
Background The airway epithelium generates reactive oxygen species (ROS) as a first line of defense. Dual oxidases (DUOX1 and DUOX2) are the H 2 O ‐producing isoforms nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family in epithelium. purpose this study was to explore molecular expression, function, regulation DUOXs chronic rhinosinusitis (CRS). Methods Human nasal tissue samples secretions were collected from 3 groups patients undergoing sinus surgery (normal, n = 7; CRS with...
Electrocochleography has been introduced to aid the diagnosis of endolymphatic hydrops. The aim this study was evaluate clinical effectiveness extratympanic electrocochleography in Ménière's disease.The medical records patients diagnosed as having disease at department otolaryngology were reviewed retrospectively. Thirty-seven healthy ears included calculate upper level 95th percentile range variables.Tertiary referral university hospital.One hundred fifty-eight (97 women and 61 men) without...
Abstract Background: The sphenopalatine ganglion block (SPGB) with local anesthetic is used to treat facial pain and headache of various etiologies; it has been widely during functional endoscopic sinus surgery (FESS). purpose this study was investigate whether preemptive SPGB may positively impact postoperative outcomes after FESS. Methods: A prospective, double‐blind, randomized, placebo‐controlled performed. total 60 patients (18–70 years), undergoing general anesthesia for bilateral...
Background Dehydration of airway surface liquid (ASL) disrupts normal mucociliary clearance (MCC) in sinonasal epithelium, which may lead to chronic rhinosinusitis (CRS). Abnormal chloride (Cl − ) transport is one such mechanism that contributes this disorder and can be acquired secondary environmental perturbations, as hypoxia at the tissue surface. The objective study was assess technological feasibility novel micro‐optical coherence tomography (μOCT) imaging technique for investigating...
A component of primary innate defense the nasal mucosa against inhaled pathogens includes continuous, low-level release hydrogen peroxide (H2 O2 ) into luminal secretions. Epidemiologically, an association exists between poor air quality and increased prevalence sinonasal disease. To understand effects particulate matter (PM) in mucosa, we studied H2 interleukin 8 (IL-8) after PM exposure.Human specimens were collected from surgery cultured serum-free growth medium. Cell integrity recovery...
Background Spontaneous cerebrospinal fluid (CSF) leaks have imaging findings consistent with chronically elevated intracranial pressure, such as empty sella. Meckel's cave is a CSF‐filled space that houses the trigeminal ganglion at cranial base. Our objective in this study was to evaluate “dilated” radiologic sign patients pressure spontaneous CSF and compare dimensions those from control cohort. Methods were measured documented pressure. A group of subjects who underwent magnetic resonance...