A5008622741- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Ear Surgery and Otitis Media
- Ophthalmology and Eye Disorders
- Glaucoma and retinal disorders
- Cerebral Venous Sinus Thrombosis
- Fault Detection and Control Systems
- Ear and Head Tumors
- Delphi Technique in Research
- Cerebral Palsy and Movement Disorders
- Hearing Impairment and Communication
- Cancer Genomics and Diagnostics
- Target Tracking and Data Fusion in Sensor Networks
- Lysosomal Storage Disorders Research
- Balance, Gait, and Falls Prevention
- Control Systems and Identification
- Teratomas and Epidermoid Cysts
- Otitis Media and Relapsing Polychondritis
- Antimicrobial Peptides and Activities
- Advancements in Transdermal Drug Delivery
- Hydrogen embrittlement and corrosion behaviors in metals
- Advanced Neuroimaging Techniques and Applications
- Glycogen Storage Diseases and Myoclonus
- Machine Learning in Healthcare
Samsung Medical Center
2013-2025
Sungkyunkwan University
2012-2025
Seoul National University Hospital
2024
Samsung (South Korea)
2017
Dankook University Hospital
2017
Pfizer (South Korea)
2017
Seoul National University
2016
University of California, San Diego
2006
University of California, Los Angeles
1998-2002
Samsung (India)
2002
The fault detection process is approximated with a disturbance attenuation problem. solution to this problem, for both linear time-varying and time-invariant systems, leads game theoretic filter which bounds the transmission of all exogenous signals except be detected. In limit, when bound brought zero, complete block achieved by embedding nuisance inputs into an unobservable, invariant subspace. Since same subspace structure seen in some types filters, we can claim that asymptotic itself...
Balloon eustachian tuboplasty (BET) is an emerging treatment for dilatory tube (ET) dysfunction. However, its efficacy in patients with both chronic suppurative otitis media (COM) and ET dysfunction remains unclear. The objective of the trial was to assess safety BET versus medical management (MM) alone adult COM dysfunction, which defined by a failed Valsalva maneuver. In this prospective, multicenter, randomized controlled trial, total 116 participants (121 ears) treated between January...
The incidence of horizontal canal involvement in benign paroxysmal positional vertigo (HC-BPPV) varies between reports. One the reasons for these differences is that duration symptoms was not considered. Because high spontaneous resolution rate HC-BPPV and medical referral system, frequency might change according to symptoms. We evaluated involved canals BPPV symptoms.A retrospective review.A review conducted involving 589 patients diagnosed with from January 2001 December 2006. were divided...
The aim of this study was to compare binaural performance auditory localization task and speech perception in babble measure between children who use a cochlear implant (CI) one ear hearing aid (HA) the other (bimodal fitting) those bilateral CIs.Thirteen (mean age ± SD = 10 2.9 years) with CIs 19 bimodal fitting were recruited participate. Sound assessed using 13-loudspeaker array quiet sound-treated booth. Speakers placed an arc from -90° azimuth +90° (15° interval) horizontal plane. To...
<h3>Importance</h3> Understanding the reasons for cochlear implant (CI) revision surgery and device failure rates is important clinicians when counseling patients who are considering CI. <h3>Objectives</h3> To analyze rate, surgery, survival of different models in recipients CIs. <h3>Design, Setting, Participants</h3> In this cohort study, implants at Samsung Medical Center, a tertiary referral center, were retrospectively reviewed. Patients underwent CI from October 2001 to March 2019...
Abstract Ménière’s Disease (MD) is difficult to diagnose and evaluate objectively over the course of treatment. Recently, several studies have reported MD diagnoses by MRI-based endolymphatic hydrops (EH) analysis. However, this method time-consuming complicated. Therefore, a fast, objective, accurate evaluation tool necessary. The purpose study was develop an algorithm that can accurately analyze EH on intravenous (IV) gadolinium (Gd)-enhanced inner-ear MRI using artificial intelligence...
Gentamicin is well known to promote hair cell death in inner ear, but it also appears activate opposing pathways that survival. In combination with others, our previous work has indicated a K-Ras/Rac/JNK pathway important for and an H-Ras/Raf/MEK/Erk involved promoting survival (Battaglia et al., Neuroscience 122(4):1025-1035, 2003). However, these data suggested Ras-independent activation of MEK might be stimulated by gentamicin. To investigate alternatives the Ras/Raf/MEK/Erk survival,...
Postoperative external auditory canal (EAC) stenosis is the most common complication after congenital aural atresia (CAA) surgery. The authors applied an ear mold or hearing aid as EAC stent following surgery and analyzed impact on postoperative stenosis.Historical cohort study.A tertiary hospital.Ninety-six patients who underwent canaloplasty between 1996 2010 were included in this study. To discover factors contributing to stenosis, clinical parameters, including age, sex, Marx grading,...
Electrocochleography has been introduced to aid the diagnosis of endolymphatic hydrops. The aim this study was evaluate clinical effectiveness extratympanic electrocochleography in Ménière's disease.The medical records patients diagnosed as having disease at department otolaryngology were reviewed retrospectively. Thirty-seven healthy ears included calculate upper level 95th percentile range variables.Tertiary referral university hospital.One hundred fifty-eight (97 women and 61 men) without...
To evaluate the clinical effectiveness of performing electrocochleography (ECoG) at initial visit in predicting hearing outcomes.Retrospective study.Tertiary hospital.Ninety patients with unilateral, definite Ménière's disease.The summating potential (SP)/action (AP) ratio was obtained using ECoG visits. An SP/AP greater than 0.34 considered abnormal.Audiogram types, fluctuations, thresholds and last visits, changes, caloric response, treatment outcomes were analyzed subjects normal abnormal...
Conclusions. The findings suggest that nuclear factor (NF)-κB is activated by cisplatin and plays a proapoptotic role during cell death in the auditory line HEI-OC1. Objectives. Cisplatin very effective antineoplastic drug but high doses it shows ototoxicity inducing apoptosis of hair cells cochlea. NF-κB transcription regulating many organs tissues. This study examined apoptotic pathway induced line, Materials methods. Apoptotic was identified measuring caspase 3 activity immunostaining...
To evaluate the auditory and speech outcome in deaf children with parents (CDP) after cochlear implantation (CI), emphasizing both presence of additional caregiver patients' main communication mode.Retrospective case review.Cochlear implant center at a tertiary referral hospital.Fourteen CDP 14 age- sex-matched normal-hearing (CNH).The Korean version Ling's stage (K-Ling) Category Auditory Perception (CAP) were administered to assess production perception abilities, preoperatively 3, 6, 12,...
Background/Aims: To investigate the incidence of cholangiocarcinoma in patients with hepatolithiasis or without previous resection liver.Methods: From 2002 to 2009, we retrospectively reviewed 117 who were diagnosed and treated for Korea University Guro Hospital.Among patients, 55 lost during follow-up excluded, 62 eligible analysis.The hepatic group (n=25) included underwent left hemihepatectomy (n=2); lateral segmentectomy (n=10); lobectomy (n=9); right (n=3); wedge (n=1).The nonhepatic...
Our goal was to find the clinical value of cervical vestibular evoked myogenic potential (VEMP) in Ménière's disease (MD) and evaluate whether VEMP results can be useful assessing stage MD. Furthermore, we tried effectiveness predicting hearing outcomes.The amplitude, peak latency interaural amplitude difference (IAD) ratio were obtained using VEMP. The MD compared with those normal subjects, stages IAD ratio. Finally, changes analyzed according their results.In clinically definite...
This study compared white matter development in prelingually deaf and normal-hearing children using a tract-based spatial statistics (TBSS) method. Diffusion tensor imaging (DTI) was performed 21 (DEAF group) 20 (HEAR subjects aged from 1.7 to 7.7 years. Using TBSS, we evaluated the regions of significant difference fractional anisotropy (FA) between groups. Correlations FA values age each group were also analyzed voxel-wise correlation analyses on TBSS skeleton. Lower tract Heschl’s gyrus,...
Patients with sudden hearing loss and dizziness after barotrauma should be suspected of barotraumatic perilymph fistula (PLF). Early surgical repair PLF showed better outcomes. Therefore, diagnostic criteria help indications PLF.The aim this study was to establish for PLF.Twenty-four patients (26 ears) underwent surgery on suspicion PLF. The causes clinical symptoms were analyzed by findings. Diagnostic proposed according its manifestations.Definite (17 subjects) confirmed any evidence leak...
Recently, the analysis of endolymphatic hydropses (EHs) via inner ear magnetic resonance imaging (MRI) for patients with Ménière disease has been attempted in various studies. In addition, artificial intelligence rapidly incorporated into medical field. our previous studies, an automated algorithm EH was developed by using a convolutional neural network. However, several limitations existed, and further studies were conducted to compensate these limitations.The aim this study is develop...
Abstract Intravenous gadolinium-enhanced inner-ear magnetic resonance imaging (IV-Gd MRI) has been used to visualize endolymphatic hydrops (EH) in clinical diagnosis of Ménière’s disease (MD). However, lack histological validation led several concerns regarding how best interpret the resulting images. Here, we compared hydropic changes temporal bone specimens with results IV-Gd MRI patients MD. Histopathologic images bones from 37 MD and 10 healthy controls were collected National Temporal...
Abstract Mucopolysaccharidosis (MPS) II is an X‐linked metabolic disorder caused by dysfunction of iduronate‐2‐sulfatase (I2S). This abnormality causes the progressive accumulation incompletely degraded glycosaminoglycans (GAGs) in lysosomes. The auditory characteristics MPS mouse models have not been reported. In this study, we evaluated IDS knock‐out (IDS‐KO) mice. addition, effect enzyme replacement therapy (ERT) on hearing was studied. IDS‐KO mice had normal histology cochlea and...
Objective: The purpose of the study was to evaluate audiologic findings according mucopolysaccharidosis (MPS) subtypes and estimate hearing changes as disease progressed, well therapeutic effect enzyme replacement therapy on apparatus. Methods: A total 124 patients who were diagnosed with MPS between September 1994 December 2016 retrospectively analyzed. Play audiometry or pure-tone performed for assessment, auditory brainstem response conducted in poor compliance. Results: In identified,...