A5047320764- Sinusitis and nasal conditions
- Cystic Fibrosis Research Advances
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Bacterial biofilms and quorum sensing
- Tissue Engineering and Regenerative Medicine
- Pancreatic function and diabetes
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Head and Neck Surgical Oncology
- Oral microbiology and periodontitis research
- Advancements in Transdermal Drug Delivery
- Nanoplatforms for cancer theranostics
- Neonatal Respiratory Health Research
- Nasal Surgery and Airway Studies
- Dermatology and Skin Diseases
- Congenital Ear and Nasal Anomalies
- Photodynamic Therapy Research Studies
- Bone and Dental Protein Studies
- Diabetes Management and Research
- Advanced biosensing and bioanalysis techniques
- Transportation Safety and Impact Analysis
- Silk-based biomaterials and applications
- Automotive and Human Injury Biomechanics
- Spinal Cord Injury Research
University of Alabama at Birmingham
2016-2025
Brigham and Women's Hospital
2016
Harvard University
2016
Abstract Electrospinning has been widely used to fabricate scaffolds imitating the structure of natural extracellular matrix (ECM). However, conventional electrospinning produces tightly compacted nanofiber layers with only small superficial pores and a lack bioactivity, which limit usefulness in biomedical applications. Thus, porous poly(ε‐caprolactone) (PCL)/gelatin composite electrospun scaffold crater‐like structures was developed. Porous were created on by gas foaming/salt leaching...
Pseudomonas aeruginosa is frequently implicated in difficult-to-treat infectious cases due to its resistance conventional antibiotics and ability form biofilms [1, 2]. To avoid limitations of systemic antibiotic drug delivery, our previous studies explored the feasibility a localized treatment approach using novel ciprofloxacin azithromycin sinus stent (CASS) treat sinusitis [3, 4]. It double-layered, with an inner hydrophilic outer hydrophobic azithromycin. This double-layered coating...
Background Dehydration of airway surface liquid (ASL) disrupts normal mucociliary clearance (MCC) in sinonasal epithelium, which may lead to chronic rhinosinusitis (CRS). Abnormal chloride (Cl − ) transport is one such mechanism that contributes this disorder and can be acquired secondary environmental perturbations, as hypoxia at the tissue surface. The objective study was assess technological feasibility novel micro‐optical coherence tomography (μOCT) imaging technique for investigating...
Background Chronic rhinosinusitis (CRS) is a chronic inflammatory disease characterized by persistent inflammation and bacterial infection. Ciprofloxacin azithromycin are commonly prescribed antibiotics for CRS, but the ability to provide targeted release in sinuses could mitigate side effects improve drug concentrations at infected site. This study was aimed evaluate efficacy of novel ciprofloxacin‐azithromycin sinus stent (CASS) vitro. Methods The CASS created coating ciprofloxacin...
Peptide amphiphile (PA) is a peptide-based biomaterial that can self-assemble into nanostructured gel-like scaffold, mimicking the chemical and biological complexity of natural extracellular matrix. To evaluate capacity PA scaffold to improve islet function survival in vitro, rat islets were cultured three different groups--(1) bare group: isolated 12-well nontissue culture-treated plate; (2) insert modified chambers; (3) nanomatrix encapsulated within gel chambers. Over 14 days, both groups...
Fibrous scaffolds that reconstruct the extracellular matrix (ECM) have been utilized for tissue regeneration demonstrated potential guiding stem cell differentiation. Nanofibrous fabricated by a unique electrospinning method enabled us to create tailored, functional on-demand. Several patterned electrospun poly(ε-caprolactone) (PCL) were prepared, and then creating hybrid composite in which bone-like hydroxyapatite (b-HA) was deposited onto scaffolds. The mineral deposits PCL confirmed...
Background We recently developed a novel ciprofloxacin‐coated sinus stent capable of releasing antibiotics over sustained period time. Ivacaftor is cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that has synergistic bactericidal activity with ciprofloxacin and also enhances mucociliary clearance. The objective this study was to optimize evaluate the efficacy ciprofloxacin‐ ivacaftor‐releasing biodegradable (CISS) in vitro. Methods A CISS created by coating...
Objectives Previously, we developed a novel double‐coated sinus stent containing ciprofloxacin (inner layer) and azithromycin (outer (CASS), but released drug concentrations were found to be insufficient for clinical usage. Our objectives are improve release of CASS assess safety pharmacokinetics in rabbits. Methods Dip coating was used create the with 2 mg 5 azithromycin. A uniformed double assessed scanning electron microscopy (SEM), patterns both drugs lactate dehydrogenase (LDH) assay...
Background The ciprofloxacin‐coated sinus stent (CSS) has unique therapeutic potential to deliver antibiotics the sinuses. objective of this study is evaluate efficacy CSS in eliminating Pseudomonas aeruginosa infection a rabbit model sinusitis. Methods A ciprofloxacin‐eluting was created by coating ciprofloxacin/Eudragit RS100 on biodegradable poly‐D/L‐lactic acid (2 mg). After analyzing in‐vitro inhibition P (PAO‐1 strain) biofilm formation, total 8 stents (4 shams, 4 CSSs) were placed...
Background Pseudomonas aeruginosa is common in chronic rhinosinusitus (CRS) and frequently resistant to antibiotic treatment. We recently described the ciprofloxacin ivacaftor‒releasing biodegradable sinus stent (CISS)―a drug‐delivery system that administers mucociliary activator (ivacaftor) at high local concentrations with prolonged mucosal contact time sustained delivery. The objective of this study evaluate efficacy CISS a rabbit model P (PAO1 strain) sinusitis. Methods...
Understanding the role of pancreatic extracellular matrix (ECM) in supporting islet survival and function drives pursuit to create biomaterials that imitate restore ECM microenvironment. To an mimic holding bioinductive cues for β‐cells, self‐assembled peptide amphiphiles (PAs) inscribed with four selected ECM‐derived cell adhesive ligands are synthesized. After 7 days, compared control groups cultured on biologically inert substrates, MIN6 β‐cells PAs functionalized YIGSR RGDS exhibit...