A5103236219- Head and Neck Surgical Oncology
- Endometrial and Cervical Cancer Treatments
- Sinusitis and nasal conditions
- Bacterial biofilms and quorum sensing
- Cystic Fibrosis Research Advances
- Bone Tumor Diagnosis and Treatments
- Selenium in Biological Systems
- Cancer-related cognitive impairment studies
- Oral and Maxillofacial Pathology
- Cervical Cancer and HPV Research
- Reconstructive Surgery and Microvascular Techniques
- Olfactory and Sensory Function Studies
- Nanoparticles: synthesis and applications
- Management of metastatic bone disease
- Neonatal Respiratory Health Research
- Bone fractures and treatments
- Cerebrospinal fluid and hydrocephalus
- Trauma Management and Diagnosis
- Head and Neck Cancer Studies
- Arsenic contamination and mitigation
- Congenital Ear and Nasal Anomalies
- Allergic Rhinitis and Sensitization
- Ovarian cancer diagnosis and treatment
- Innovations in Concrete and Construction Materials
- Oral health in cancer treatment
University of Alabama at Birmingham
2018-2024
The University of Texas MD Anderson Cancer Center
2015-2024
St. Mary's University, Texas
2020
Universidad de Santiago de Chile
2014-2015
Universidad Pontificia Bolivariana
2015
Yarrowia lipolytica has fast become a biotechnologically significant yeast for its ability to accumulate lipids high levels. While there exists suite of synthetic biology tools genetic engineering in this yeast, is need multipurposed rapid strain generation. Here, we describe dual purpose CRISPR-Cpf1 system that capable simultaneous gene disruption and regulation. Truncating guide RNA spacer length 16 nt inhibited nuclease activity but not binding the target loci, enabling activation...
Background We recently developed a novel ciprofloxacin‐coated sinus stent capable of releasing antibiotics over sustained period time. Ivacaftor is cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that has synergistic bactericidal activity with ciprofloxacin and also enhances mucociliary clearance. The objective this study was to optimize evaluate the efficacy ciprofloxacin‐ ivacaftor‐releasing biodegradable (CISS) in vitro. Methods A CISS created by coating...
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result defective Cl- transport and cause chronic bacterial infections upper lower airways of (CF) patients. Ivacaftor is a CFTR potentiator that improves CF patients with at least 1 copy G551D mutation. Resveratrol also potent increases determinants mucociliary transport. The objective this study to determine whether resveratrol ivacaftor improve secretion over either agent alone.Fisher rat thyroid cells (FRT)...
Background Biofilms may contribute to refractory chronic rhinosinusitis (CRS), as they lead antibiotic resistance and failure of effective clinical treatment. l ‐Methionine is an amino acid with reported biofilm‐inhibiting properties. Ivacaftor a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator mild antimicrobial activity via inhibition bacterial DNA gyrase topoisomerase IV. The objective this study was evaluate whether co‐treatment ivacaftor ‐methionine can reduce the...
Free flap (FF) reconstruction of traumatic injuries to the head and neck is uncommon.
Background The osteoplastic flap provides access to pathology of the frontal sinus and is often performed with obliteration, which can result in significant long-term complications. Objective To describe authors’ approach without obliteration. Methods Descriptive analysis. Results Osteoplastic obliteration preserves function while permitting direct sinus. In this study, we demonstrate a combined nonobliterated approach, accessing Draf III remove large osteoma. Conclusion excellent exposure...
The aim of this study was to survey gynecologic oncologists and fellows-in-training regarding the role radical trachelectomy (RT) conservative surgery in patients with early-stage cervical cancer.From June 2012 September 2012, Society Gynecologic Oncology member practitioners (n = 1353) oncology fellows 156) were sent group-specific surveys investigating current practice, training, future RT for cancer management.Twenty-two percent 303) 24.4% 38) completed surveys. Of practitioners, 50% 148)...
Background Sinonasal and skull‐base tumors that previously required open resection can often be completely resected via an endonasal approach. The nasoseptal flap (NSF) is the workhorse vascularized tissue for endoscopic reconstruction of large defects from tumor resections. objective current article to describe a novel modification NSF simultaneous medial orbital wall defects. Methods An extension standard include mucosa lateral nasal was developed closure Outcomes including successful...
The goal of this work was to enhance tellurite toxicity against Gram positive bacteria, especially Staphyloccocus aureus. Using a combination assays (growth inhibition zones, growth curves, and minimal inhibitory concentrations), bacterium tested in the presence various SH- OH-containing compounds. Results showed that noxiousness strongly enhanced 2-mercaptoethanol or dithiothreitol. potentiating effect observed S. aureus ATCC 6538 (the model organism study) other bacteria such as Bacillus...
Abstract Background: Primary brain tumor (PBT) patients experience cognitive dysfunction (CD) because of both their and its treatment. Evaluating CD in PBT populations may inform patient outcomes clinical management allow exploration biologic underpinnings associated with occurrence. The Montreal Cognitive Assessment (MoCA) is a brief assessment objective measures cognition that evaluates 8 specific domains. Our group has previously reported the feasibility MoCA, this study includes using...
Abstract Cognitive impairment is common in primary brain tumor (PBT) patients, with approximately 60% of diffuse glioma patients suffering from cognitive impairments at least one domain. Gliomas exist within complex neuronal networks leading to hypotheses that associations between isocitrate dehydrogenase (IDH) mutation gliomas and cognition, but the effects biology on these intrinsic are poorly understood contribution specific mechanisms unclear. Higher levels proteins linked...
ABSTRACT Background This study compares the outcomes of osteocutaneous radial forearm free flap (OC‐RFFF) and fibula (FFF) reconstruction mandibular osteoradionecrosis (ORN). Methods Retrospective review patients undergoing OC‐RFFF/FFF for mandible ORN between 2005 2020 at a tertiary center. Patient characteristics, postoperative complications, functional were evaluated using chi‐squared logistic regression analysis. Results Fifty‐six included (OC‐RFFF: 38; FFF: 18). Significantly more...
This survey was designed to evaluate exposure sentinel mapping for cervical and endometrial cancers in addition the quality availability of surgical training procedures around world. Furthermore, we aimed identify obstacles procedure support adoption this technique clinical practice. A 52-item developed computed using Qualtrics XM SurveyMonkey software. The target population were members European Society Gynaecological Oncology International Gynecological Cancer aged ≤40 years. study...
Spontaneous cerebrospinal fluid (sCSF) leaks develop from pressure erosion due to idiopathic intracranial hypertension, treatment of which is paramount preventing recurrence. Direct measurements (ICP) for monitoring response via lumbar drain (LD) or ventriculostomy are invasive and have risks. The objectives this study determine whether ultrasonographic optic nerve sheath diameter (ONSD) correlate with LD ICP in patients sCSF undergoing treatment, ONSDs larger than controls.Subjects controls...
<h3>Introduction/Background</h3> Sentinel lymph node mapping (SLN) for endometrial (EC) and cervical cancer (CC) is routinely performed worldwide. However, it has not yet been integrated into practice universally. Early career gynaecologic oncologists training practices in SLN were assessed a global survey. <h3>Methodology</h3> An anonymous questionnaire containing 53 questions was distributed via email to the ESGO-ENYGO IGCS member database. Respondents who younger than 40 years of age...