A5091234250- Electrospun Nanofibers in Biomedical Applications
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Tissue Engineering and Regenerative Medicine
- Clinical Nutrition and Gastroenterology
- Pulmonary Hypertension Research and Treatments
- Ion Channels and Receptors
- Sulfur Compounds in Biology
- Gastrointestinal motility and disorders
- Mast cells and histamine
- Tracheal and airway disorders
- Silk-based biomaterials and applications
- RNA Interference and Gene Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cell Adhesion Molecules Research
- Supramolecular Self-Assembly in Materials
- Enhanced Recovery After Surgery
- Vascular Anomalies and Treatments
- Ion channel regulation and function
- Regulation of Appetite and Obesity
- Anesthesia and Neurotoxicity Research
- Asthma and respiratory diseases
- Pericarditis and Cardiac Tamponade
- Olfactory and Sensory Function Studies
- Bone Tissue Engineering Materials
Piedmont Athens Regional
2024
Virginia Commonwealth University
2014-2023
University of Alabama at Birmingham
2009-2010
Nanofibrous electrospun poly (ε-caprolactone) (ePCL) scaffolds have inherent structural advantages, but lack of bioactivity has limited their usefulness in biomedical applications. Thus, here we report the development a hybrid, nanostructured, extracellular matrix (ECM) mimicking scaffold by combination ePCL nanofibers and self-assembled peptide amphiphile (PA) nanofibers. The PAs ECM characteristics including cell adhesive ligand (RGDS) metalloproteinase-2 (MMP-2) mediated degradable sites....
Abstract Hydrogen sulfide (H 2 S) plays an important role in smooth muscle relaxation. Here, we investigated the expression of enzymes H S synthesis and mechanism regulating colonic function by S. Expression cystathionine‐γ‐lyase (CSE), but not cystathionine‐β‐synthase (CBS), was identified rabbit, mouse, human. Carbachol (CCh)‐induced contraction rabbit strips isolated cells inhibited l ‐cysteine (substrate CSE) NaHS (an exogenous donor) a concentration‐dependent fashion. induced...
ET-1 signalling modulates intestinal motility and inflammation, but the role of ET-1/ET
"Hemoptysis" refers to the expectoration of blood from respiratory tract. However, "life-threatening hemoptysis" includes any volume that leads features such as airway obstruction, hypoxia, or hemodynamic instability. We present a case life-threatening hemoptysis in 65-year-old male with history benign prostatic hyperplasia and uncontrolled hypertension. Radiological investigations revealed pseudo-aneurysm at site prior thoracic aortic coarctation repair more than 50 years childhood. He...
Abstract Background l ‐amino acids, such as monosodium glutamate (MSG), activate the umami receptor T1R1/T1R3. We previously showed increased peristalsis in response to activation of T1R1/T1R3 by MSG mouse colon. However, expression and function these receptors different regions stomach are not clear. Methods Mouse gastric smooth muscle cells (SMCs) were isolated cultured Dulbecco’s Modified Eagle Medium. Expression T1R1 T1R3 was measured RT‐PCR Western blot. The effect with without inosine...
The extracellular matrix (ECM) provides physical scaffolding for cells but also is essential many biochemical and biomechanical cues in tissue differentiation homeostasis. Under normal physiologic conditions, ECM degradation deposition act equilibrium. Increased depostion are processes known to be critical epithelial-to-mesenchymal-transition (EMT) during the pathogenesis of cancer fibrosis. exact mechanism underlying EMT Idiopathic Pulmonary Fibrosis, however, remains uncertain. There...