A5101830327- Antifungal resistance and susceptibility
- Viral Infections and Outbreaks Research
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- Pulmonary Hypertension Research and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Thermal Regulation in Medicine
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Cell Adhesion Molecules Research
- Biochemical and Structural Characterization
- Parasitic Diseases Research and Treatment
- Pneumonia and Respiratory Infections
- Fungal Infections and Studies
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Vaccine Coverage and Hesitancy
Virginia Commonwealth University
2015-2023
Massachusetts Institute of Technology
2022
Scripps Research Institute
2016
Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause of inherited form Parkinson's disease (PD), while LRRK2 overactivation is also associated with more common idiopathic PD. large multidomain protein, including GTPase as well Ser/Thr protein domain. Common, disease-causing mutations increase activity, presenting an attractive target drug discovery. Currently, development has mainly focused on ATP-competitive inhibitors. Here, we report identification and...
Secondary pneumonia occurs in 8-24% of patients with Coronavirus 2019 (COVID-19) infection and is associated increased morbidity mortality. Diagnosis secondary can be challenging. The purpose this study was to evaluate the use plasma microbial cell free DNA sequencing (mcfNGS) evaluation after COVID-19. We performed a single-center case series COVID-19 who underwent mcfNGS reported organisms identified, concordance available tests, clinical utility, outcomes. In 8/13 (61%) cases, detected...
Members of the Ebolavirus genus including Zaire ebolavirus (EBOV), Sudan (SUDV) and Budibugyo (BDBV) cause viral hemorrhagic fever have high case fatality rates. The current outbreak in Western Africa is largest on record has infected over 28,000 individuals, yet no currently approved vaccines or therapeutics exist. Previous reports revealed that ZMapp™, a cocktail three antibodies target glycoprotein (GP) EBOV, can revert an active infection nonhuman primates. A group recently identified...
The extracellular matrix (ECM) provides physical scaffolding for cells but also is essential many biochemical and biomechanical cues in tissue differentiation homeostasis. Under normal physiologic conditions, ECM degradation deposition act equilibrium. Increased depostion are processes known to be critical epithelial-to-mesenchymal-transition (EMT) during the pathogenesis of cancer fibrosis. exact mechanism underlying EMT Idiopathic Pulmonary Fibrosis, however, remains uncertain. There...
Abstract Background Distinguishing COVID-19 Associated Pulmonary Aspergillosis (CAPA) and invasive mold infections (IMIs) from other causes of secondary pneumonia in can be challenging. 1,3-β-D-Glucan galactomannan are commonly utilized biomarkers for the workup IMIs but limited by a lack specificity sensitivity respectively. Cell-free plasma next-generation sequencing (cfNGS) is promising non-invasive approach that provide direct detection pathogens patient's serum. This study explored its...