A5063362354- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Cystic Fibrosis Research Advances
- Nasal Surgery and Airway Studies
- Asthma and respiratory diseases
- Craniofacial Disorders and Treatments
- Parathyroid Disorders and Treatments
- Infection Control and Ventilation
- Oral microbiology and periodontitis research
- Neurosurgical Procedures and Complications
- Allergic Rhinitis and Sensitization
- Animal Genetics and Reproduction
- Pneumonia and Respiratory Infections
- Inhalation and Respiratory Drug Delivery
- Meningioma and schwannoma management
- Estrogen and related hormone effects
- Teratomas and Epidermoid Cysts
- Osteomyelitis and Bone Disorders Research
- Neonatal Respiratory Health Research
- Medical Imaging and Pathology Studies
- Pancreatic and Hepatic Oncology Research
- Dental Research and COVID-19
- Effects and risks of endocrine disrupting chemicals
- Probiotics and Fermented Foods
- COVID-19 and healthcare impacts
Indiana University School of Medicine
2024
Indiana University – Purdue University Indianapolis
2024
University of Alabama at Birmingham
2019-2022
Auburn University
2017
Background Chronic rhinosinusitis (CRS) is a chronic inflammatory disease characterized by persistent inflammation and bacterial infection. Ciprofloxacin azithromycin are commonly prescribed antibiotics for CRS, but the ability to provide targeted release in sinuses could mitigate side effects improve drug concentrations at infected site. This study was aimed evaluate efficacy of novel ciprofloxacin‐azithromycin sinus stent (CASS) vitro. Methods The CASS created coating ciprofloxacin...
Background: Chronic rhinosinusitis (CRS) is characterized by complex bacterial infections with persistent inflammation. Based on our rabbit model of sinusitis, blockage sinus ostia generated a shift in microbiota to predominance mucin degrading microbes (MDM) acute inflammation at 2 weeks. This was followed conversion chronic 3 months robust increase pathogenic bacteria (e.g., Pseudomonas). MDMs are known produce acid metabolites [short chain fatty acids (SCFA)] that have the potential...
Lipopolysaccharide (LPS) serves as the interface between gram-negative bacteria (GNB) and innate immune response in respiratory epithelial cells (REC). Herein, we describe a novel biological role of LPS that permits GNB to persist tract through inducing CFTR mucociliary dysfunction. reduced cystic fibrosis transmembrane conductance regulater (CFTR)-mediated short-circuit current mammalian REC Ussing chambers nearly abrogated single channel activity (defined forskolin-activated Cl- currents)...
Objective Spontaneous cerebrospinal fluid (CSF) leaks represent a unique subset of skull base pathology and require distinctive management. Perioperative evaluation management intracranial hypertension are essential in preventing further erosion the development recurrent leak. The objective this study is to evaluate safety utility an expedited protocol for recording managing following endoscopic repair spontaneous CSF leaks. Methods Prospectively collected data was reviewed patients...
Background We recently developed a ciprofloxacin and azithromycin sinus stent (CASS) to target recalcitrant infections in chronic rhinosinusitis (CRS). The objective of this study was evaluate the anti‐inflammatory activity released from CASS assess impact on integrity function primary human sinonasal epithelial cells (HSNECs). Methods Pseudomonas aeruginosa lipopolysaccharide (LPS)‐stimulated HSNECs were treated with and/or at concentrations attainable release. Interleukin‐8 (IL‐8)...
Objective Frontal sinus osteomyelitis is a severe complication which can result from chronic rhinosinusitis, trauma, or as of reconstruction obliteration the frontal sinus. The objective current study to evaluate contemporary management in light recent advancements endoscopic surgical techniques. Methods Review prospectively collected database patients with pathology was performed 2008–2020. Data individuals including demographics, etiology, technique, adjunctive medical treatments,...
Epithelial ion transport regulates hydration of airway mucosal surfaces, and thus promotes effective mucociliary clearance (MCC). Decreased transepithelial Cl- may contribute to epithelial dysfunction by abrogating MCC increasing mucus viscosity in chronic rhinosinusitis (CRS). The objective the current study is evaluate channel properties from cultures human sinonasal epithelia.Human epithelia (HSNE) patients undergoing sinus surgery were cultured at an air-liquid interface confluence full...
Hormonally active agents are released into the environment from industrial and manufacturing activity. Evidence in literature indicates that impaired reproductive capacity wildlife laboratory species is associated with chemical exposures. In particular, bisphenol A (BPA) di (2-ethylhexyl) phthalate (DEHP) have generated public interest due to their presence several consumer products. this study, we determined expression of steroid hormone receptors (estrogen androgen receptors), Wnt4,...