A5058524052- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Natural product bioactivities and synthesis
- Geochemistry and Elemental Analysis
- Healthcare and Venom Research
- Extraction and Separation Processes
- Protein purification and stability
- Exercise and Physiological Responses
- Pharmacological Effects of Natural Compounds
- Reproductive System and Pregnancy
- Muscle metabolism and nutrition
- Traditional Chinese Medicine Studies
- Heavy metals in environment
- Retinoids in leukemia and cellular processes
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Phytochemical compounds biological activities
- Arsenic contamination and mitigation
- MicroRNA in disease regulation
- Aluminum toxicity and tolerance in plants and animals
- Biological Activity of Diterpenoids and Biflavonoids
- Traditional Chinese Medicine Analysis
- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Thermoregulation and physiological responses
Chengdu University of Traditional Chinese Medicine
2025
Gannan Medical University
2010-2025
State Key Laboratory of Food Science and Technology
2015-2020
Nanchang University
2015-2020
Cornell University
2010
Cleveland Clinic
2010
Johns Hopkins University
2010
Sichuan University
2010
West China Hospital of Sichuan University
2010
University of California, San Francisco
2010
Background Many people die from cardiovascular diseases each year, and extreme temperatures are regarded as a risk factor for deaths. However, the relationship between temperature deaths varies in different regions because of population density, demographic inequality, economic situation, evidence Ganzhou, China is limited inconclusive.Objective This study aimed to assess temperature-related mortality identify potential vulnerable people.Methods After controlling other meteorological...
Hydroquinone (HQ) is widely used in food stuffs and an occupational environmental pollutant. Although the hepatotoxicity of HQ has been demonstrated both vitro vivo, prevention HQ‐induced yet to be elucidated. In this study, we focused on intervention effect aqueous extracts Flos lonicerae Japonicae (FLJ) cytotoxicity. We that reduced cell viability a concentration‐dependent manner by administering 160 μ mol/L for 12 h as positive control The FLJ significantly increased decreased LDH...
The growing presence of yttrium (Y) in the environment raises concern regarding its safety and toxicity. However, limited toxicological data are available to determine cardiotoxicity Y underlying mechanisms. In present study, chloride (YCl3) intervention with different doses was performed male Kunming mice for evaluation heart. After 28 days intragastric administration, 500 mg/kg·bw YCl3 induces iron accumulation cardiomyocytes, triggers ferroptosis through glutathione peroxidase 4...
Arsenic (As) is a ubiquitous environmental and industrial toxin with known correlates of oxidative stress cognitive deficits in the brain. Nuclear factor erythroid 2-related 2 (Nrf2) transcriptional that represents central cellular antioxidant defense mechanism transcribes many genes. Peroxisome proliferator-activated receptor-gamma (PPARγ) well-known nuclear receptor to regulate lipid metabolism tissues, it has been also associated control stress, neuronal death, neurogenesis...
Competitive enzyme-linked immunosorbent assay (ELISA) is the most widely used method for rapidly screening of mycotoxins in contaminated food products; however, it involves use toxin-protein conjugates as a competitive antigen and toxin standards calibrators. In this work, single domain heavy chain antibody (VHH)-based environmentally friendly ELISA (VHH-ELISA) was developed to measure citrinin concentration Monascus-fermented rice. With novel indirect VHH-ELISA, synthetic pure toxins...
Abnormal blood-brain barrier (BBB) is a common pathological feature in brain damage. In the present study, microvascular endothelial cell (BMEC) model was established to determine role of toll‑like receptor 4 (TLR4)/protein kinase Cα (PKCα)/occludin signaling pathway BBB dysfunction. Three small interfering (si)RNAs directed against PKCα were designed investigate molecular mechanisms underlying BMECs divided into groups: Control group, TAK‑242 (a TLR4 inhibitor) PKCα‑siRNA group and...
<title>Abstract</title> Rare earth elements (REEs) are increasingly recognized as significant environmental pollutants due to their persistence, bioaccumulation, and chronic toxicity. This study assessed REEs pollution in soil, water, vegetables an ion-adsorption rare mining area Ganzhou, evaluated the associated health risks local population. Results indicated that content soil ranged from 168.58 1915.68 mg/kg, with average of 546.71 substantially surpassing background level for Jiangxi...
Objective: To study the effect of hesperidin extracted from peel Gannan kumquat on cell proliferation and apoptosis human poorly diferentiated nasopharyongeal carcinoma epithelial (CNE-2Z). Methods: Effect CNE-2Z cells was detected by MTT method. utilized acridine orange / ethidium bromide staining Results: After being treated with different for 24, 48 72 h respectively, inhibited in vitro; time had high significant difference (F = 1898.865, P <;; 0.001), pharmacal concentration 5454.040,...
Objective: To study the effect of hesperidin extracted from peel Gannan kumquat on Alzheimer's disease and its possible mechanisms. Methods: Cellular model was established using PC 12 cell induced by serum starvation method treated β-amyloid peptide 25-35 (Aβ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">25-35</sub> ). Effect proliferation PC12 AP detected MTT method. apoptosis Aβ utilized acridine orange/ethidium bromide staining Results:...
To explore the antioxidative effect of hesperidin extracted from peel Gannan kumquat on exercise fatigue. Methods: Hesperidin was by ultrasound and ethanol precipitation detected qualitatively high performance liquid chromatography. Animal model fatigue established 10-day increasing progressively swimming training. Effect serum glutathione peroxidase, superoxide dismutase, catalase, myeloperoxidase maleic dialdehyde exercise-fatigue rats tested spectrophotometric method. Results: The had...
To study the effect of hesperidin extracted from peel Gannan kumquat on bone marrow polychromatophilic erythroblast micronucleus exercise fatigue. Methods: Hesperidin was by ultrasound and ethanol precipitation detected qualitatively high performance liquid chromatogramphy. Effect micronuclear rate erythroblasts rat used test. Results: The rats fatigue had some phenomena, such as depilation, tired appearance, low appetite, degressive locomotory capacity slow-moving growth body weight....