A5101177412- Biomedical Text Mining and Ontologies
- Bioinformatics and Genomic Networks
- Cardiac Arrest and Resuscitation
- Traditional Chinese Medicine Studies
- Respiratory viral infections research
- Pharmacological Effects of Natural Compounds
- Medicinal Plant Pharmacodynamics Research
- Educational Technology and Assessment
- Acute Kidney Injury Research
- Neurological Disease Mechanisms and Treatments
- Diet and metabolism studies
- Machine Learning in Healthcare
- Immune Response and Inflammation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Climate Change and Health Impacts
- Cholesterol and Lipid Metabolism
- Artificial Intelligence in Healthcare and Education
- Gut microbiota and health
- Erythropoietin and Anemia Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Cell Adhesion Molecules Research
- Peroxisome Proliferator-Activated Receptors
- Blood transfusion and management
- Biochemical effects in animals
- Sepsis Diagnosis and Treatment
Zhejiang Chinese Medical University
2010-2024
Zhejiang University
2021
Objectives: Large language models (LLMs) can harness medical knowledge for intelligent question answering (Q&A), promising support auxiliary diagnosis and talent cultivation. However, there is a deficiency of highly efficient retrieval-augmented generation (RAG) frameworks within the domain Traditional Chinese Medicine (TCM). Our purpose to observe effect Tree-Organized Self-Reflective Retrieval (TOSRR) framework on LLMs in TCM Q&A tasks. Materials Methods: We introduce novel approach...
Objective: Vasculitis is the basic pathological change of systemic lupus erythematosus (SLE). Radix Paeoniae Rubra (RPR), a traditional Chinese herb with function reducing blood stasis, has anti-inflammatory and immunoregulatory properties. This study explored effects RPR on kidneys lupus-like symptoms mrl (MRL/lpr) mice from perspective intercellular cell adhesion molecule-1 (ICAM-1), vascular (VCAM-1) platelet endothelial (PECAM-1). Methods: Eighteen MRL/lpr model were randomly divided...
Anemia is a risk factor for acute kidney injury (AKI) following cardiopulmonary bypass (CPB). Whether red blood cell (RBC) transfusion-enhanced hemoglobin levels contribute to low AKI rates remains unclear. We investigated the interaction between hemoglobin, RBC transfusion, and after CPB. Hemoglobin trajectories within 72 h were analyzed using group-based trajectory analysis. Multivariable logistic analysis inverse probability-weighted regression adopted evaluate associations in non-RBC...
Modern research and clinical practice have proved that Traditional Chinese Medicine (TCM) has unique advantages in the treatment of diabetes. JinXiaoXiaoKe decoction (JXXKD) is a prescription for treating diabetes used ancient China still good effect today. However, mechanism JXXKD against T2DM unclear. The purpose this study to screen targets through network pharmacology, explore therapeutic on diabetic rats. JXXKD's active components, related were obtained from public database, Venny 2.1...
Knowledge graphs (KGs) can integrate domain knowledge into a traditional Chinese medicine (TCM) intelligent syndrome differentiation model. However, the quality of current KGs in TCM varies greatly, related to lack graph completion (KGC) and evaluation methods.
The uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a novel metabolic marker and is proven be associated with diabetes risk. However, there still lack of systematic research regarding its role in gender differences underlying mechanisms. This study aims assess the association UHR risk context investigate mediation effects through inflammatory pathways. utilized data from NHANES 2005–2010 included 6,843 adult participants. Multivariate logistic regression was...
Fine particulate matter (PM2.5) is well known to impair lung function. Strategies protecting against PM2.5-exerted dysfunction have been less investigated. Qianjinweijing decoction (QJWJ), a of herbal medicine natural origin, has used treat disorders as it inhibits oxidation and inflammation. However, no clinical trial yet evaluated the role QJWJ in PM2.5-induced dysfunction. Therefore, we conducted randomized, double-blind, placebo-controlled assess whether provided benefits adverse effects...
Objectives: To assess the efficacy and safety of oral glucokinase activator (GKA) in treatment type 2 diabetes mellitus(T2DM). Methods: We searched PubMed, ClinicalTrails, Cochrane Library, Web Science, CNKI collected randomized controlled trials (RCTs) T2DM. Revman5.3 software was used to do meta-analysis. And risk bias included RCTs evaluated according tool. Results: Seven double-blind RTCs were final analysis, with a total 762 patients. Regarding efficacy, GKAs significantly reduced...
Ethnopharmacological relevance: Huanglian Zhimu Decoction (HLZMD) is a Chinese medicine used to treat type 2 diabetes mellitus(T2DM) since the ancient Tang Dynasty, but mechanism still unknown.Aim of study: To study effects and mechanisms HLZMD in T2DM rats.Materials methods: The rats were fed customized high-fat diet naturally generated model. was for 12 weeks. body weight, food water intake, urine output, fasting blood glucose measured weekly. Automated biochemistry instruments detected...
<sec> <title>BACKGROUND</title> Knowledge graphs (KGs) can integrate domain knowledge into a traditional Chinese medicine (TCM) intelligent syndrome differentiation model. However, the quality of current KGs in TCM varies greatly, related to lack graph completion (KGC) and evaluation methods. </sec> <title>OBJECTIVE</title> This study aims investigate KGC methods tailored for knowledge. <title>METHODS</title> In phase, according characteristics knowledge, we proposed 3-step...
Objective To explore the effects of Jiedu Quyu Ziyin Recipe (JQZR) on apoptosis and expressions bcl-2 bax mRNA peripheral-blood lymphocyte in MRL/lpr mice. Methods 80 mice were randomly divided into model group,TCM group, Western medicine group TCM group,20 each meanwhile,20 Kunming selected as normal then intragastrically administered sodium, JQZR apozem, prednisone suspension apozem suspension, 0. 5ml every time,once daily for 12 weeks respectively. At end 12th week, lymphocytes purified...