A5072476166- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Circadian rhythm and melatonin
- Reproductive System and Pregnancy
- Energy and Environment Impacts
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Endometriosis Research and Treatment
- Neuroscience and Neuropharmacology Research
- Heme Oxygenase-1 and Carbon Monoxide
- Psychological and Temporal Perspectives Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Microplastics and Plastic Pollution
- Genetic Associations and Epidemiology
- Gynecological conditions and treatments
- Sphingolipid Metabolism and Signaling
- Cardiovascular Disease and Adiposity
- Nutritional Studies and Diet
- Surface Modification and Superhydrophobicity
- Optimism, Hope, and Well-being
- Zebrafish Biomedical Research Applications
- Genetic Syndromes and Imprinting
- Occupational exposure and asthma
Zhejiang Chinese Medical University
2017-2024
China International Science and Technology Cooperation
2022-2024
Zhejiang University
2022-2024
Sir Run Run Shaw Hospital
2022-2024
Tongji University
2022
New York University
2021
The Ohio State University
2021
Shanghai University of Traditional Chinese Medicine
2019
Huashan Hospital
2019
Fudan University
2019
Abstract Background & aims Emerging evidence supports ambient fine particulate matter (PM 2.5 ) exposure is associated with insulin resistance (IR) and hepatic lipid accumulation. In this study, we aimed to evaluate the sex-dependent vulnerability in response PM investigate underlying mechanism by which modulates metabolism. Methods Both male female C57BL/6 mice were randomly assigned or filtered air for 24 weeks via a whole body system. High-coverage quantitative lipidomics approaches...
Microplastics (MPs), the emerging environmental pollutants, have attracted global attention due to potential public health challenge and ecological security risk. Recent studies suggested liver as a vulnerable organ MPs exposure, evidenced by abnormal hepatic lipid metabolism upon intake in multiple animal species. However, specific changes of mammalian livers, well underlying mechanisms, remain be elucidated. In present study, C57BL/6 mice were randomly assigned normal drinking water or...
Abstract Endometriosis is a common gynecological disorder that causes female infertility. Our recent research found excessive oxidative stress in ovaries of endometriosis patients induced senescence cumulus granulosa cells. Here, we analyzed the transcriptomic and metabolomics profiles follicles mouse model with investigated potential function changed metabolites RNA‐sequencing indicated both lesions mice abnormalities reactive stress, steroid hormone biosynthesis, lipid metabolism. The...
Defective decidualization of endometrial stromal cells (ESCs) in endometriosis (EM) patients leads to inadequate receptivity and EM-associated infertility. Hypoxia is an inevitable pathological process EM participates deficient the eutopic secretory endometrium. Enhancer zeste homology 2 (EZH2) a methyltransferase which catalyses H3K27Me3, leading decreased expression levels target genes. Although EZH2 low under normal decidualization, it abundantly increased endometrium induced by hypoxia....
Silicosis is characterized by chronic lung inflammation and fibrosis, which are extremely harmful to human health. The pathogenesis of silicosis involves uncontrolled immune processes. Evidence supports that regulatory B cells (Bregs) produce negative cytokines, such as IL-10, can negatively regulate responses in autoimmune diseases. Our previous study found IL-10-producing (B10) were involved the development silica-induced fibrosis mice. However, little known about role patients. In this...
The consumption of disposable materials is booming with the rapid development urbanization and industrialization, which may inevitably cause release toxic harmful substances during use them in daily life. This study was to estimate element levels such as Beryllium (Be), Vanadium (V), Zinc (Zn), Manganese (Mn), Cadmium (Cd), Chromium (Cr), Nickel (Ni), Cobalt (Co), Antimony (Sb), Barium (Ba), Lead (Pb), Iron (Fe), Copper (Cu), Selenium (Se) leachate subsequently assess health risk exposure...
Recent studies have shown that some adverse pregnancy outcomes, especially intrauterine growth restriction (IUGR), are associated with gestational exposure to ambient fine particulate matter (PM2.5). However, potential mechanism remains be elucidated. In the present study, pregnant C57BL/6 mice were randomly assigned exposed either filtered air or PM2.5 in gestation period via a concentrated whole-body system. We found exerted no effect on implantation, preterm delivery, as well fetal...
Emerging evidence suggests that exposure to airborne fine particulate matter (PM2.5) is closely related disturbances in hepatic lipid metabolism. However, no systematic study assessed the age vulnerability effects of PM2.5 on metabolism, and potential mechanisms remain unknown. This aimed investigate metabolic susceptibility different life stages exposure, evaluate underlying molecular mechanisms. Male C57BL/6 mice at three phases (young, adult, middle-aged) were exposed simultaneously...
Plenty of literature has documented that fine particulate matter (PM2.5) exposure is related to blood pressure (BP) elevation. Vascular dysfunction the initiation cardiovascular diseases, such as hypertension. This thesis set out assess role Toll-like receptor 3 (TLR3) in increase BP induced by PM2.5.C57BL/6 and TLR3 deficient (TLR3-/-) male mice were randomly allocated filtered air chamber or real-world inhaled concentrated PM2.5 chamber. was evaluated using non-invasive recordings. After...
Abstract Fine particulate matter (PM 2.5 ) is suggested to pose a severe risk the kidneys by inducing functional degradation and chronic kidney diseases (CKD). This study aims explore nephrotoxicity of PM exposure underlying mechanism. Herein, based on UK Biobank, it found that per interquartile range (IQR) increase in associated with 6% (95% CI: 1%–11%), 7% 3%–11%), 9% 4%–13%), 11% 9%–13%), 10% 8%–12%) nephritis, hydronephrosis, stone, acute renal failure, CKD, respectively. In experimental...
Introduction Multiple targets are considered as the causes of ambient fine particulate matter [aerodynamic diameters < 2.5 μm (PM )] induced lung function injury. Qiju granules derived from traditional Chinese medicine (TCM) formula known Qi-Ju-Di-Huang-Wan (Lycium, Chrysanthemum, and Rehmannia Formula, QJDHW), which has been traditionally used to treat symptoms such cough with phlegm, dry mouth throat, liver heat. This treatment approach involves attenuating inflammation, oxidative...
Alcoholic liver disease (ALD) is one of the most prevalent chronic worldwide. Alcohol-induced alterations in hepatic lipids play an important role ALD develpoment and progression. The present study aimed to thoroughly describe changes lipid profiling mice with early-stage alcoholic disease.C57BL/6J male aged 7-week were randomized into alcohol-fed (AF) group pair-fed control (PF) (n = 10 per group). early stage was induced Lieber-DeCarli liquid diet. analyzed by absolute quantitative...
Pregnancy is a unique physiological stage for females as well vulnerable period pollutant exposure. The effect of gestational ambient fine particulate matter (PM2.5) exposure on maternal lipid metabolism during pregnancy rarely observed, and the mechanism unknown. In current study, pregnant C57BL/6 mice were randomly assigned to either PM2.5 or filtered air chambers since day (GD) 0. Meanwhile, non-pregnant female housed controls in each chamber. exerted no significant body weight gain...
Recent research has highlighted a correlation between exposure to ambient fine particulate matter (PM
The disruption of circadian rhythms (CRs) has been linked to metabolic disorders, yet the role hepatic BMAL1, a key regulator, in whole-body metabolism and associated lipid phenotype liver remains unclear. Bmal1 floxed (Bmal1f/f) hepatocyte-specific knockout (Bmal1hep−/−) C57BL/6J mice underwent regular feeding regimen. Hepatic CR, content, mitochondrial function, systemic were assessed at zeitgeber time (ZT) 0 ZT12. Relevant molecules examined elucidate phenotype. Hepatocyte-specific...
Emerging evidence supports that exposure to ambient fine particulate matter (PM2.5) is associated with the metabolic syndrome. As main neuroendocrine axis in mammals, hypothalamic-pituitary-adrenal (HPA) axis's circadian rhythm (CR) plays an essential role regulating homeostasis. Our previous studies found PM2.5 caused CR disorder of critical enzymes involved lipid metabolism mouse liver and adipose tissues. However, impact on HPA not fully illustrated yet. Male C57BL/6 mice were randomly...
Abstract The mechanism by which endometriosis, a common gynecological disease characterized chronic pelvic pain and infertility, causes infertility remains elusive. Luteinized unruptured follicle syndrome, the most type of ovulatory dysfunction, is cause endometriosis-associated involving reduced numbers retrieved mature oocytes. Ovulation controlled luteinizing hormone paracrine signals produced within microenvironment. Generally, interleukin (IL)-1β elevated in endometriosis follicular...
Recent studies have shown a strong correlation between ambient fine particulate matter (PM