A5065446533- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Energy and Environment Impacts
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Thermoregulation and physiological responses
- Healthcare and Venom Research
- Acupuncture Treatment Research Studies
- Cardiovascular Disease and Adiposity
- Olfactory and Sensory Function Studies
- Traditional Chinese Medicine Studies
- Drug Transport and Resistance Mechanisms
- Biomarkers in Disease Mechanisms
- Liver Disease Diagnosis and Treatment
- Spaceflight effects on biology
- Diet and metabolism studies
- Birth, Development, and Health
- Psychological and Temporal Perspectives Research
Zhejiang Chinese Medical University
2020-2024
China International Science and Technology Cooperation
2022-2024
Recent studies have shown that some adverse pregnancy outcomes, especially intrauterine growth restriction (IUGR), are associated with gestational exposure to ambient fine particulate matter (PM2.5). However, potential mechanism remains be elucidated. In the present study, pregnant C57BL/6 mice were randomly assigned exposed either filtered air or PM2.5 in gestation period via a concentrated whole-body system. We found exerted no effect on implantation, preterm delivery, as well fetal...
Emerging evidence suggests that exposure to airborne fine particulate matter (PM2.5) is closely related disturbances in hepatic lipid metabolism. However, no systematic study assessed the age vulnerability effects of PM2.5 on metabolism, and potential mechanisms remain unknown. This aimed investigate metabolic susceptibility different life stages exposure, evaluate underlying molecular mechanisms. Male C57BL/6 mice at three phases (young, adult, middle-aged) were exposed simultaneously...
Both epidemiological and experimental studies increasingly show that exposure to ambient fine particulate matter (PM
Plenty of literature has documented that fine particulate matter (PM2.5) exposure is related to blood pressure (BP) elevation. Vascular dysfunction the initiation cardiovascular diseases, such as hypertension. This thesis set out assess role Toll-like receptor 3 (TLR3) in increase BP induced by PM2.5.C57BL/6 and TLR3 deficient (TLR3-/-) male mice were randomly allocated filtered air chamber or real-world inhaled concentrated PM2.5 chamber. was evaluated using non-invasive recordings. After...
Abstract Fine particulate matter (PM 2.5 ) is suggested to pose a severe risk the kidneys by inducing functional degradation and chronic kidney diseases (CKD). This study aims explore nephrotoxicity of PM exposure underlying mechanism. Herein, based on UK Biobank, it found that per interquartile range (IQR) increase in associated with 6% (95% CI: 1%–11%), 7% 3%–11%), 9% 4%–13%), 11% 9%–13%), 10% 8%–12%) nephritis, hydronephrosis, stone, acute renal failure, CKD, respectively. In experimental...
Emerging evidence supports that exposure to ambient fine particulate matter (PM2.5) is associated with the metabolic syndrome. As main neuroendocrine axis in mammals, hypothalamic-pituitary-adrenal (HPA) axis's circadian rhythm (CR) plays an essential role regulating homeostasis. Our previous studies found PM2.5 caused CR disorder of critical enzymes involved lipid metabolism mouse liver and adipose tissues. However, impact on HPA not fully illustrated yet. Male C57BL/6 mice were randomly...
Exposure to fine particulate matter (PM2.5), which contains substantial nanoscale matter, induced metabolic disorder. As a critical organ with the potential for energy expenditure induction, inguinal white adipose tissue (iWAT) browning has hardly been examined exposure PM2.5 nanoparticles. This study aimed explore effects of ambient on iWAT and underlying mechanisms gain deeper understanding disorders. Based characterization we observed that impaired browning, accompanied by inhibition its...
Airborne fine particulate matter (PM
Dysosmia affects not only odour identification, but also memory, appetite, immunity and affection. Moreover, it suggests the occurrence of some diseases. The etiology dysosmia is various treatment with western medicine limited. In this paper, by analyzing relevant research articles on olfactory disorders acupuncture moxibustion, clinical application thought its diagnosis as well effect mechanism were explored. It anticipated to provide physicians references dysosmia.
Global climate warming has drawn worldwide attention. However, the health impact of heat exposure is still controversial. This study aimed to explore exact effects and sex differential vulnerability under intermittent (IHE) patterns tried elucidate potential mechanisms by which IHE modulated hepatic lipid glucose homeostasis. Both female male C57BL/6 N mice were randomly allocated control group (22 ± 1 °C) or (37 °C for 6 h) 9 consecutive days followed 4-day recovery at 22 in a whole-body...
It is to determine the effect mechanism and therapeutic method of idea as guiding meridian sinew qi along with running course for disorders so provide reference clinical treatment these disorders. Guiding summary approach by YANG Shang-shan, recorded in Huangdi Mingtang Jing (The Yellow Emperor's Acupoints Canon ), but concrete statement on it had been lost. By investigating existing ancient works, authors discussed specific meaning jinqi (meridian relationship between jingjin sinew) jingmai...