A5051279667- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Urinary and Genital Oncology Studies
- Heat shock proteins research
- Bladder and Urothelial Cancer Treatments
- Redox biology and oxidative stress
- RNA Research and Splicing
- Hormonal and reproductive studies
- Nanoparticle-Based Drug Delivery
- Prostate Cancer Diagnosis and Treatment
- Diagnosis and treatment of tuberculosis
- Urinary Bladder and Prostate Research
- Prostate Cancer Treatment and Research
- Superconductivity in MgB2 and Alloys
- Inflammatory Biomarkers in Disease Prognosis
- Histone Deacetylase Inhibitors Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Bone Metabolism and Diseases
- Pharmacovigilance and Adverse Drug Reactions
- Pediatric Urology and Nephrology Studies
- Bone health and treatments
- RNA modifications and cancer
- Academic integrity and plagiarism
- Bone health and osteoporosis research
Tianjin Medical University
2010-2025
Second Hospital of Tianjin Medical University
2010-2025
Tianjin Medical University General Hospital
2024
Emerging evidence has suggested that patients with metastatic prostate cancer will become resistant after receiving docetaxel (DTX) chemotherapy, but the specific regulatory mechanism is still unclear. lincROR an important oncogenic long noncoding RNA which plays role in regulating tumor carcinogenesis and metastasis; however, underlying of functioning DTX resistance process remains largely unknown. In current study, we found highly expressed DTX-resistant cell lines was associated poor...
Abstract Background Like DNA methylation, histone modifications are considered important processes for epigenetic alterations in gene function, and abnormally high expression of deacetylases (HDACs) plays a key role many human diseases. In addition to regulating the acetylation levels non‐histone proteins transcription, HDAC inhibitors as antitumor drugs can also affect damage repair (DDR) pathway tumor cells. Prostate cancer (PCa) is one most heritable malignancies which DDR defects be...
Abstract Objective To explore if switching intravesical chemotherapeutic agents is beneficial in short-term recurrences of high-risk non-muscle-invasive bladder cancer (NMIBC) following the failure preceding therapy. Materials and methods From June 2010 to October 2015, 205 patients with NMIBC who experienced tumor recurrence within a year after receiving first-line chemotherapy (IVC) were classified into two groups. After second complete transurethral resection (TUR) process, we immediately...
The specific risk factors contributing to the development of osteoporosis and appropriate timing treatment in Chinese prostate cancer (PCa) patients remain unclear. Our objective was develop validate a nomogram capable predicting occurrence PCa patients.We conducted cross-sectional study with attending Second Hospital Tianjin Medical University, collecting data from June 2021 February 2023. were divided into training validation sets 7:3 ratio. LASSO regression used identify most relevant...
Background: Bladder cancer (BC), as a common type of cancer, has poor prognosis, also some invasive prognostic or therapeutic markers are difficult to obtain, which makes further treatment BC difficult. Glycyl-tRNA synthetase (GARS), one the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids, been identified target in many diseases, including tumors.
Increasing research efforts are focused on studying the synthesis and mechanisms of nanomedicine in urologic cancer. We performed a bibliometric study literature cancer over last 23 years, focusing aspects such as researchers, institutions, nations, keywords. searched for papers Web Science Core Collection from January 1, 2001, to December 29, 2023. Only reviews original articles written English were considered. A total 2386 satisfied given criteria inclusion. The publications included...
Background Several observational studies have reported an association between gut microbiota and male erectile dysfunction (ED). However, it remains unclear whether there is a causal relationship ED. Thus, we aimed to investigate the potential ED through Mendelian randomization (MR) analysis. Objective To assess ED, performed two-sample MR Methods We obtained genome-wide (GWAS) data from MiBioGen consortium publicly available GWAS on OPEN database. Subsequently, analysis evaluate Finally,...
<div>Abstract<p>Emerging evidence has suggested that patients with metastatic prostate cancer will become resistant after receiving docetaxel (DTX) chemotherapy, but the specific regulatory mechanism is still unclear. lincROR an important oncogenic long noncoding RNA which plays role in regulating tumor carcinogenesis and metastasis; however, underlying of functioning DTX resistance process remains largely unknown. In current study, we found highly expressed DTX-resistant cell...
Bladder cancer (BLCA) is a commonly diagnosed worldwide that exhibits high rates of recurrence and metastasis. Immunotherapy increasingly being recognised in the clinical management bladder cancer. In addition, prospect developing Natural Killer (NK) cell-related immunotherapy promising BLCA.
<p>qPCR primers</p>
<p>S1. A. CCK-8 assay was used to detect the cytotoxicity of DTX in DTX-resistant PCa cells (PC3/DR and DU145/DR) their parental sensitive (PC3 DU145). B. The list hypoxia-related lncRNAs from Pubmed top 80 upregulated PC3/DR RNA-seq (Jiang X, et al. Front Oncol, 2022). data are presented as mean ± S.D. at least three independent experiments. *P < 0.05. S2. relative expression lincROR evaluated by qRT-PCR PC3 DU145 after being transfected with lincROR. were treated different dosages...
<p>S1. A. CCK-8 assay was used to detect the cytotoxicity of DTX in DTX-resistant PCa cells (PC3/DR and DU145/DR) their parental sensitive (PC3 DU145). B. The list hypoxia-related lncRNAs from Pubmed top 80 upregulated PC3/DR RNA-seq (Jiang X, et al. Front Oncol, 2022). data are presented as mean ± S.D. at least three independent experiments. *P < 0.05. S2. relative expression lincROR evaluated by qRT-PCR PC3 DU145 after being transfected with lincROR. were treated different dosages...
<p>qPCR primers</p>
<p>S1. A. CCK-8 assay was used to detect the cytotoxicity of DTX in DTX-resistant PCa cells (PC3/DR and DU145/DR) their parental sensitive (PC3 DU145). B. The list hypoxia-related lncRNAs from Pubmed top 80 upregulated PC3/DR RNA-seq (Jiang X, et al. Front Oncol, 2022). data are presented as mean ± S.D. at least three independent experiments. *P < 0.05.S2. relative expression lincROR evaluated by qRT-PCR PC3 DU145 after being transfected with lincROR. were treated different dosages...
<div>Abstract<p>Emerging evidence has suggested that patients with metastatic prostate cancer will become resistant after receiving docetaxel (DTX) chemotherapy, but the specific regulatory mechanism is still unclear. lincROR an important oncogenic long noncoding RNA which plays role in regulating tumor carcinogenesis and metastasis; however, underlying of functioning DTX resistance process remains largely unknown. In current study, we found highly expressed DTX-resistant cell...
<p>qPCR primers</p>
<p>qPCR primers</p>
<p>S1. A. CCK-8 assay was used to detect the cytotoxicity of DTX in DTX-resistant PCa cells (PC3/DR and DU145/DR) their parental sensitive (PC3 DU145). B. The list hypoxia-related lncRNAs from Pubmed top 80 upregulated PC3/DR RNA-seq (Jiang X, et al. Front Oncol, 2022). data are presented as mean ± S.D. at least three independent experiments. *P < 0.05.S2. relative expression lincROR evaluated by qRT-PCR PC3 DU145 after being transfected with lincROR. were treated different dosages...