A5028184866- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Esophageal Cancer Research and Treatment
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Urological Disorders and Treatments
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cancer Mechanisms and Therapy
- Urinary Bladder and Prostate Research
- Advanced biosensing and bioanalysis techniques
- Genetic and Kidney Cyst Diseases
- Boron and Carbon Nanomaterials Research
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Immune cells in cancer
- Adrenal and Paraganglionic Tumors
- Nuts composition and effects
- RNA Interference and Gene Delivery
- Inflammatory Biomarkers in Disease Prognosis
- Sexual function and dysfunction studies
Tianjin Medical University
2014-2025
Second Hospital of Tianjin Medical University
2014-2025
National Center for Nanoscience and Technology
2022-2023
Center for NanoScience
2023
Abstract In the past decade, nucleic acid‐based drugs have emerged as an extremely promising approach for silencing specific disease‐related genes and targeting undruggable ones. However, most acid drug therapies not advanced to clinical practice due their poor stability against serum enzyme degradation cytotoxicity. Nanoscale delivery vehicles show potential improve efficacy of via targeted disease‐causing genes, yet, safe efficient nanocarriers remain elusive. Lipid‐based nanoparticles...
New strategies to decrease risk of relapse after surgery are needed for improving 5-year survival rate hepatocellular carcinoma (HCC). To address this need, a wound-targeted nanodrug is developed, that contains an immune checkpoint inhibitor (anti-PD-L1)and angiogenesis (sorafenib)). These nanoparticles consist highly biocompatible mesoporous silica (MSNP) surface-coated with platelet membrane (PM) achieve surgical site targeting in self-amplified accumulation manner. Sorafenib introduced...
Abstract Purpose: Combinations of immune checkpoint inhibitors and nab-paclitaxel have improved outcomes in advanced urothelial carcinoma muscle-invasive bladder cancer. This study evaluates the safety efficacy tislelizumab combined with low-dose extensive very high-risk (VHR) non-muscle-invasive cancer (NMIBC). Patients Methods: TRUCE-02 was a single-arm phase 2 trial that included 63 patients visually incomplete resection and/or high-volume high-grade T1 tumors (with or without situ), who...
Objective To explore the feasibility and efficacy of modified technique totally intracorporeal ileal conduit (IC) construction via vaginal approach following robot-assisted radical cystectomy (RARC) in females.
<div>AbstractPurpose:<p>Combinations of immune checkpoint inhibitors and nab-paclitaxel have improved outcomes in advanced urothelial carcinoma muscle-invasive bladder cancer. This study evaluates the safety efficacy tislelizumab combined with low-dose extensive very high–risk non–muscle-invasive cancer.</p>Patients Methods:<p>TRUCE-02 was a single-arm phase II trial that included 63 patients visually incomplete resection and/or high-volume high-grade T1 tumors (with...
<p>Supplementary Figure S1. Schematic protocol diagram.</p>
<p>Supplementary Figure S2. Duration of complete response any disease.</p>
Abstract Growing evidence has indicated that circular RNAs (circRNAs) play crucial roles in multiple biological processes. However, alterations circRNA profiles during bladder cancer progression and the clinical significance thereof remain unclear. Therefore, high‐throughput RNA sequencing was conducted to identify mRNA five pairs of tissues adjacent noncancerous tissues. A total 87 differentially expressed circRNAs 2756 mRNAs were detected above samples compared with paired samples....
Conformational cooperativity is a universal molecular effect mechanism and plays critical role in signaling pathways. However, it remains challenge to develop artificial networks regulated by conformational cooperativity, due the difficulties programming controlling multiple structural interactions. Herein, we cooperative strategy signals, rather than chemical regulate protein-oligonucleotide signal transduction, taking advantage of programmability allosteric DNA constructs. We generate...
Ribosomal stress is known to increase cancer risk; however, the molecular mechanism underlying its various effects on remains unclear. To decipher this puzzle, we investigated upstream signaling pathway that might be involved in promoting ribosomal leads tumor progression. Our results suggested inhibition of kinase PIM1 attenuated PC3 cell growth and motility following condensed cellular body decreased protein translation PIM1-inhibited cells. In addition, was found a component small 40S...
Despite its significant clinical efficacy as a first-line treatment for advanced bladder cancer, cisplatin-based chemotherapy provides limited benefit patients with lymphovascular invasion (LVI), which is characterized by the presence of tumor emboli within blood vessels and associated enhanced cisplatin resistance metastatic potential. Notably, platelets, critical component LVI, hinder delivery chemotherapeutic agents to tumors facilitate metastasis. Consequently, platelet function...
Liver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins primarily produced activated hepatic stellate cells (HSCs). The activation HSCs plays a pivotal role in driving progression liver fibrosis. Achieving specific targeted delivery antifibrotic agents toward remains formidable challenge. Here, we developed an HSC membrane-camouflaged nanosystem, named HSC-PLGA-BAY, for precise antifibrosis agent BAY 11-7082 to treatment designed HSC-PLGA-BAY nanosystem...
Hexavalent chromium [Cr(VI)], one common environmental contaminant, has long been recognized as a carcinogen associated with several malignancies, such lung cancer, but little information was available about the effects of its low-dose exposure in prostate cancer. Our previous study shown that Cr(VI) could promote cancer(PCa) cell growth vitro and vivo. In present study, we furthermore found induce DNA demethylation PCa cells. Based on our transcriptome sequencing data methylation database,...
Increasing evidences have demonstrated that circular RNA (circRNAs) plays a an essential regulatory role in initiation, progression and immunotherapy resistance of various cancers. However, circRNAs rarely been studied bladder cancer (BCa). The purpose this research is to explore new their potential mechanisms BCa. A novel ceRNA-regulated network, including 87 differentially expressed (DE-circRNAs), 126 DE-miRNAs, 217 DE-mRNAs was constructed better understanding the biological processes...
Genome-wide association studies (GWAS) have identified a number of genetic variants associated with risk bladder cancer in populations European descent. Here, we assessed two these variants, rs11892031 (2q37.1 region) and rs401681 (5p15.33 Chinese case-control study, which included 367 cases 420 controls. We found that the AC genotype was remarkably decreased (adjusted odds ratio (OR), 0.27; 95% confidence interval (CI), 0.09–0.81; p = 0.019), compared AA rs11892031; CT/CC genotypes were...
Abstract Objective To explore if switching intravesical chemotherapeutic agents is beneficial in short-term recurrences of high-risk non-muscle-invasive bladder cancer (NMIBC) following the failure preceding therapy. Materials and methods From June 2010 to October 2015, 205 patients with NMIBC who experienced tumor recurrence within a year after receiving first-line chemotherapy (IVC) were classified into two groups. After second complete transurethral resection (TUR) process, we immediately...