H Chen

ORCID: 0000-0003-4232-4153
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About
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Research Areas
  • Bariatric Surgery and Outcomes
  • Body Contouring and Surgery
  • Cardiovascular Disease and Adiposity
  • Breast Cancer Treatment Studies
  • Metastasis and carcinoma case studies
  • Antibiotic Resistance in Bacteria
  • Immunodeficiency and Autoimmune Disorders
  • Anorectal Disease Treatments and Outcomes
  • Spaceflight effects on biology
  • Sports injuries and prevention
  • Cell death mechanisms and regulation
  • Acupuncture Treatment Research Studies
  • Cancer Diagnosis and Treatment
  • Human Health and Disease
  • Diet and metabolism studies
  • Bacterial Identification and Susceptibility Testing
  • Complementary and Alternative Medicine Studies
  • Cancer Immunotherapy and Biomarkers
  • bioluminescence and chemiluminescence research
  • Celiac Disease Research and Management
  • Phagocytosis and Immune Regulation
  • Inflammatory Bowel Disease
  • Cancer and Skin Lesions
  • Antibiotics Pharmacokinetics and Efficacy
  • Diverticular Disease and Complications

Dalian Medical University
2025

First Affiliated Hospital of Dalian Medical University
2025

Lanzhou University Second Hospital
2024

Sichuan University
2024

Harbin Medical University
2024

Second Affiliated Hospital of Harbin Medical University
2024

Lanzhou University
2024

Second Hospital of Anhui Medical University
2023

The First People’s Hospital of Lianyungang
2020-2023

Jiangsu Province Hospital
2011-2023

Abstract Background The body weight following bariatric surgery is a primary concern for both healthcare professionals and surgical candidates. However, it remains unclear whether variations in preoperative fat distribution influence loss outcomes. Objective aim of this study was to evaluate the effect abdominal on postoperative mass index (BMI) reduction, clarify role different depots Methods Preoperative data from patients with overweight or obesity, along their records at 1, 2 5 years...

10.1111/dom.16172 article EN Diabetes Obesity and Metabolism 2025-01-09

B10 cells restore immune balance by producing interleukin (IL)-10. Impaired cell responses are related to numerous autoimmune diseases. However, the function of in type 1 diabetes (T1D) patients is controversial. We hypothesized that there numerical and functional defects T1D. Sixty-two with T1D 74 healthy volunteers were included our study. showed human peripheral blood belong a CD24hi CD38hi B subpopulation. from individuals possessed regulatory capacity, suppressed interferon (IFN)-γ,...

10.1111/cei.13408 article EN Clinical & Experimental Immunology 2019-12-18

Abstract Background Inflammation and dysregulated immunity play vital roles in idiopathic pulmonary arterial hypertension (IPAH), while the mechanisms that initiate promote these processes are unclear. Methods Transcriptomic data of lung tissues from IPAH patients controls were obtained Gene Expression Omnibus database. Weighted gene co-expression network analysis (WGCNA), differential expression analysis, protein-protein interaction (PPI) functional enrichment combined with a...

10.1186/s12967-024-05304-6 article EN cc-by Journal of Translational Medicine 2024-05-26

Background It is encountering the dilemma of lacking precise biomarkers to predict response neoadjuvant chemoimmunotherapy (NACI) and determine whether patients should use immune checkpoint inhibitors (ICIs) in early breast cancer (BC). We aimed develop a gene signature NACI for BC identify individuals suitable adding ICIs. Patients methods Two I-SPY2 cohorts one West China Hospital cohort treated with were included. Machine learning algorithms used key genes. Principal component analysis...

10.1136/jitc-2024-009587 article EN cc-by-nc-nd Journal for ImmunoTherapy of Cancer 2024-08-01

Objective This prospective study compared the efficacy and safety of laparoscopic gastric bypass sleeve gastrectomy in treating overweight obese patients with BMI>28 kg/m2 type-2 diabetes.Methods Patients were randomized into a group (n = 77) or 80). The surgery time, intraoperative blood loss, recovery hospitalization time collected. BMI, waistline, hipline, C-peptide level, insulin resistance index (HOMA-IR), their lipid profile also measured.Results Surgery loss significantly higher...

10.1080/09674845.2020.1798578 article EN British Journal of Biomedical Science 2020-08-24

ABSTRACT Introduction Knee joint injury is a common sports and how to speed up the recovery process concern for all athletes. Objective Determine whether aquatic rehabilitation nursing can accelerate of knee injuries. Methods Thirty patients with ligament or meniscal were divided into an group control group. The assumed general measures, while exercise was added another 8 weeks exercises. evolution degree pain, range motion, muscle strength other indicators before after experiment compared....

10.1590/1517-8692202329012022_0807 article EN Revista Brasileira de Medicina do Esporte 2023-01-01

Background Acupuncture practice plays an important role in healthcare China as well the world. 2011, Academy of Chinese Medical Sciences (CACMS) published 5 Clinical guidelines (CPGS) acupuncture, which were only CPGS specialised for acupuncture China. Our research was to systematically review quality these CPGS. Methods We evaluated through guideline appraisal instrument: Appraisal Guidelines Research and Evaluation II (AGREE II). Four appraisers rated 6 domains separately. Results None...

10.1136/bmjqs-2013-002293.159 article EN BMJ Quality & Safety 2013-08-01

Abstract Background Fecal incontinence (FI) is a common complaint that seriously affects the quality of life in patients with Crohn’s disease (CD). We aimed to identify risk factors related FI and construct prediction model for CD. Methods Four hundred sixty-one diagnosed CD between June 2016 April 2021 Jiangsu Province Hospital Chinese Medicine were retrospectively enrolled this study randomly divided into development (n=368) internal validation cohort (n=93). FI-related selected from using...

10.1093/ecco-jcc/jjac190.0461 article EN Journal of Crohn s and Colitis 2023-01-30

乳腺导管内癌是一种常见的乳腺原位癌,因肿瘤未突破基底膜,手术切除通常有效,少部分复发,极少部分以浸润癌复发。本文报道1例微乳头型乳腺导管内癌,乳腺改良根治术和内分泌治疗4年后出现同侧胸壁浸润性微乳头状癌复发,再次行化疗+放疗+内分泌治疗后随访3年无异常。本文回顾其临床病理资料并复习相关文献,以提高对该病的认识,并探讨可能的治疗方案。.

10.3760/cma.j.cn112151-20221003-00829 article EN PubMed 2023-02-08

Objective: To investigate the expression of MSI1 and HER2 in mammary Paget's disease, correlation between levels clinicopathologic characteristics prognosis patients. Methods: Clinical data paraffin-embedded specimens 34 pairs disease underlying breast cancer were collected at Department Pathology, Affiliated Lianyungang Oriental Hospital Xuzhou Medical University from March 2011 to December 2019. Immunohistochemistry was used detect accompanying cancer, analyze their features, as well...

10.3760/cma.j.cn112151-20230214-00128 article EN PubMed 2023-08-08

Abstract Background: Axillary lymph node dissection (ALND) is the standard surgical treatment for breast cancer patients who have axillary nodal metastasis but do not meet criteria of Z0011 trial. Arm lymphedema one most common and serious complications ALND. Based on hypothesis that lymphatic system upper extremity may be separate from breast, reverse mapping (ARM) technique has been developed to identify nodes lymphatics receive limb, preserve them during ALND in order prevent arm...

10.1158/1538-7445.sabcs16-p2-01-39 article EN Cancer Research 2017-02-15

Objective: A method for the determination of acetochlor and its metabolites in urine by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was established. Methods: After cleaned-up a HLB extraction cartridges, eluted with 1% acetic acid acetonitrile solution. The target compounds were separated ACQUITY UPLC®HSS T3 Column (2.1 mm×100 mm×1.8 μm) using formic solution as mobile phase gradient elution program, analyzed positive electrospray ionization mode chromatography tandem...

10.3760/cma.j.cn121094-20210917-00464 article EN PubMed 2022-05-20
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