A5052677090- Muscle Physiology and Disorders
- Antenna Design and Analysis
- Tendon Structure and Treatment
- Advanced Antenna and Metasurface Technologies
- Metal Alloys Wear and Properties
- Microstructure and Mechanical Properties of Steels
- Knee injuries and reconstruction techniques
- Congenital heart defects research
- Connective tissue disorders research
- Metal and Thin Film Mechanics
- Extraction and Separation Processes
- Mesenchymal stem cell research
- Soil Moisture and Remote Sensing
- Shoulder Injury and Treatment
- Antenna Design and Optimization
- Neurogenetic and Muscular Disorders Research
- Ionic liquids properties and applications
- Sports injuries and prevention
- Nutrition and Health in Aging
- Microwave Engineering and Waveguides
- Fibroblast Growth Factor Research
- Congenital limb and hand anomalies
- Radio Astronomy Observations and Technology
- Surface Chemistry and Catalysis
- Advanced biosensing and bioanalysis techniques
Chiba University
2011-2025
Sumitomo Metal Mining (Japan)
2022-2025
University of Indonesia
2025
Tokyo Medical and Dental University
2023-2024
Hiroshima University
2014-2023
Nippon Steel (Japan)
2019-2023
The Graduate University for Advanced Studies, SOKENDAI
2023
High Energy Accelerator Research Organization
2023
Shizuoka University
2023
Nippon Medical School
2023
Tenomodulin (Tnmd) is a type II transmembrane glycoprotein predominantly expressed in tendons and ligaments. We found that scleraxis (Scx), member of the Twist-family basic helix-loop-helix transcription factors, transcriptional activator Tnmd expression tenocytes. During embryonic development, Scx preceded Tnmd. was nearly absent ligaments Scx-deficient mice generated by activator-like effector nucleases-mediated gene disruption. mRNA levels were dramatically decreased during serial...
Age-related sarcopenia constitutes an important health problem associated with adverse outcomes. Sarcopenia is closely fat infiltration in muscle, which attributable to interstitial mesenchymal progenitors. Mesenchymal progenitors are nonmyogenic nature but required for homeostatic muscle maintenance. However, the underlying mechanism of progenitor-dependent maintenance not clear, nor precise role sarcopenia. Here, we show that mice genetically engineered specifically deplete exhibited...
Abstract Scleraxis (Scx) is a basic helix-loop-helix transcription factor that expressed persistently in tendons/ligaments, but transiently entheseal cartilage. In this study, we generated novel Scx Cre knock-in (KI) allele, by in-frame replacement of most exon 1 with recombinase (Cre ), to drive expression using promoter and inactivate the endogenous . Reflecting intensity duration expression, Cre-mediated excision occurs tendinous ligamentous tissues expressing Expression tenomodulin,...
The periodontal ligament (PDL) is a mechanosensitive noncalcified fibrous tissue connecting the cementum of tooth and alveolar bone. Here, we report that scleraxis (Scx) osterix (Osx) antagonistically regulate tensile force-responsive PDL fibrogenesis osteogenesis. In developing PDL, Scx was induced during eruption co-expressed with Osx. highly expressed in elongated fibroblastic cells aligned along collagen fibers, whereas Osx perialveolar/apical osteogenic cells. an experimental model...
Mixtures of the protic ionic liquids trioctylammonium bis(trifluoromethanesulfonyl)amide ([TOAH][NTf2]) and nitrate ([TOAH][NO3]) were investigated as extractants for platinum-group elements. The mixture 10 wt % [TOAH][NO3] in [TOAH][NTf2] has low viscosity (274.2 mPa s) aqueous solubility (2.6 × 10–5 mol dm–3 cation). With liquid mixture, Pd(II) Pt(IV) extracted almost quantitatively from 0.10 hydrochloric acid. Under same conditions, Na(I), Mg(II), K(I), Ca(II), Mn(II), Fe(III), Co(II),...
Adult skeletal muscle has a remarkable ability to regenerate. Regeneration of mature fibers is dependent on stem cells called satellite cells. Although they are normally in quiescent state, rapidly activated after injury, and subsequently proliferate differentiate make new fibers. Myogenesis highly orchestrated biological process been extensively studied, therefore many parameters that can precisely evaluate regenerating events have established. However, some cases, it necessary the...
ABSTRACT This paper presents a novel dual‐band waveguide‐fed circularly polarised (CP) horn antenna for the feeder of synthetic aperture radar (SAR) onboard microsatellite. The proposed consists an asymmetric linearly tapered slot and waveguide feed. C‐/X‐band left‐hand circular polarisation (LHCP) design was simulated, 3D‐printed prototype fabricated to validate simulation measured in anechoic chamber. can achieve operations with 3 dB axial ratio bandwidth 40% (5–6.5 GHz; 8.5–10 GHz), VSWR...
Macrophages are key regulators of skeletal muscle regeneration, yet the specific macrophage subpopulations responsible for this process and their cell-cell interactions remain insufficiently understood, as does mechanism underlying age-related impairment regeneration. We utilized single-cell RNA sequencing to identify transcriptionally distinct within from young (8-week-old) aged (24-month-old) mice. Among them, Mac_1 subpopulation interacted with satellite cells (MuSCs) promoted...
Fibroblast growth factor (FGF) signaling plays essential roles in various biological events. FGF18 is one of the ligands to be associated with osteogenesis, chondrogenesis and bone healing. The mouse critical-sized calvarial defect healing induced by morphogenetic protein 2 (BMP2)-hydrogel stabilized when added. Here, we aimed investigate role model. We first found that + BMP2 hydrogel application increased expression anti-inflammatory markers, including those related tissue M2 macrophage...
The musculoskeletal system is integrated by tendons that are characterized the expression of scleraxis (Scx), a functionally important transcription factor. Here, we newly developed tenocyte induction method using induced pluripotent stem cells established from ScxGFP transgenic mice monitoring fluorescence, which reflects dynamic differentiation process. Among several developmentally relevant factors, transforming growth factor-beta 2 (TGF-β2) was most potent inducer for...
Abstract OASIS/CREB3L1, an endoplasmic reticulum (ER)-resident transcription factor, plays important roles in osteoblast differentiation. In this study, we identified new crosstalk between OASIS and the hypoxia signaling pathway, which regulates vascularization during bone development. RT-PCR real-time PCR analyses revealed significant decreases expression levels of hypoxia-inducible factor-1α (HIF-1α) target genes such as vascular endothelial growth factor A (VEGFA) OASIS-deficient ( Oasis...
This paper presents a method to systematically model the behaviour of prebiotic lipid–water systems over range plausible early Earth conditions.
A multipotent cell population co-expressing a basic-helix-loop-helix transcription factor scleraxis (Scx) and SRY-box 9 (Sox9) has been shown to contribute the establishment of entheses (tendon attachment sites) during mouse embryonic development. The present study aimed investigate involvement Scx + /Sox9 cells in postnatal formation fibrocartilaginous healing process after injury, using ScxGFP transgenic mice. We demonstrate that are localized layers at insertion site supraspinatus tendon...
Abstract In this study, phase transformation kinetics was directly evaluated using a femtosecond X-ray diffraction technique for operand measurements of the dislocation densities and carbon concentrations in Fe-0.1mass%C martensitic steel. To identify reverse mechanism from α′ to γ, we used an free-electron laser ultrafast heating. A maximum heating rate 10 4 °C/s, which is sufficient avoid diffusive reversion, achieved, during successfully observed. Our results demonstrated that fine...
This letter presents a novel substrate with lunar regolith simulant as major material that closely resembles the properties of regolith. It aims to support realization antennas telecommunication and remote sensing infrastructures can serve communication observation services on moon. Lunar has low-measured dielectric constant <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$({{\varepsilon...
Abstract Sarcopenia is an important health problem associated with adverse outcomes. Although the etiology of sarcopenia remains poorly understood, factors apart from muscle fibers, including humoral factors, might be involved. Here, we used cytokine antibody arrays to identify involved in and found a significant increase levels milk fat globule epidermal growth factor 8 (MFG‐E8) skeletal aged mice, compared young mice. We that MFG‐E8 protein at arterial walls neuromuscular junctions (NMJs)...
In this study, we developed an in-process sintering method for laser-assisted electrophoretic deposition (LAEPD) using additional laser to sinter Au particles and improve the Young's modulus of microstructures fabricated LAEPD. Thus, in addition (λ = 488 nm) that traps nanoparticles, another 785 was installed effectively absorb deposited nanoparticles. Deposition performed via LAEPD alternatively during fabrication. A 28.2 GPa achieved pillar with a irradiation time 1000 ms/cycle.
ABSTRACT Osteoblasts arise from bone-surrounding connective tissue containing tenocytes and fibroblasts. Lineages of these cell populations mechanisms their differentiation are not well understood. Screening enhancer-trap lines zebrafish allowed us to identify Ebf3 as a transcription factor marking cells in skeletal muscle embryos. Knockout mice had no effect on chondrogenesis but led sternum ossification defects result defective generation Runx2+ pre-osteoblasts. Conditional temporal...
In higher vertebrates, cephalic neural crest cells (NCCs) form craniofacial skeleton by differentiating into chondrocytes and osteoblasts. A subpopulation of NCCs, cardiac NCCs (CNCCs), migrates to the heart. However, CNCCs mostly do not yield skeletogenic derivatives, molecular mechanisms this fate restriction remain elusive. We identify a disintegrin metalloprotease 19 (Adam19) as position-specific regulator NCCs. Adam19-depleted mice abnormally NCC-derived cartilage in their hearts...