A5057840399- Muscle Physiology and Disorders
- Connective tissue disorders research
- Reproductive biology and impacts on aquatic species
- Parasitic Infections and Diagnostics
- Aquaculture Nutrition and Growth
- Physiological and biochemical adaptations
- Developmental Biology and Gene Regulation
- Thallium and Germanium Studies
- Congenital Anomalies and Fetal Surgery
- Adipose Tissue and Metabolism
- Cell Adhesion Molecules Research
- Telomeres, Telomerase, and Senescence
- Extracellular vesicles in disease
- Osteoarthritis Treatment and Mechanisms
- Xenotransplantation and immune response
- Mesenchymal stem cell research
- Congenital heart defects research
Institut Pasteur
2023-2024
Centre National de la Recherche Scientifique
2023-2024
Université Paris Cité
2024
Kyoto University
2018-2021
Nippon Veterinary and Life Science University
2018
ABSTRACT Skeletal muscle stem cells (MuSCs) are recognised as functionally heterogeneous. Cranial MuSCs reported to have greater proliferative and regenerative capacity when compared with those in the limb. A comprehensive understanding of mechanisms underlying this functional heterogeneity is lacking. Here, we used clonal analysis, live imaging single cell transcriptomic analysis identify crucial features that distinguish extraocular (EOM) from limb populations. MyogeninntdTom reporter...
Gene regulatory networks that act upstream of skeletal muscle fate determinants are distinct in different anatomical locations. Despite recent efforts, a clear understanding the cascade events underlying emergence and maintenance stem cell pool specific groups remains unresolved debated. Here, we invalidated Pitx2 with multiple Cre -driver mice prenatally, postnatally, during lineage progression. We showed this gene becomes progressively dispensable for specification (MuSC) extraocular...
ABSTRACT Osteoblasts arise from bone-surrounding connective tissue containing tenocytes and fibroblasts. Lineages of these cell populations mechanisms their differentiation are not well understood. Screening enhancer-trap lines zebrafish allowed us to identify Ebf3 as a transcription factor marking cells in skeletal muscle embryos. Knockout mice had no effect on chondrogenesis but led sternum ossification defects result defective generation Runx2+ pre-osteoblasts. Conditional temporal...
Nutrient transfer from mother to the embryo is essential for reproduction in viviparous animals. In teleost Xenotoca eiseni belonging family Goodeidae, intraovarian intakes maternal component secreted into ovarian fluid via trophotaenia. Our previous study reported that epithelial layer cells of trophotaenia incorporate a protein vesicle trafficking. However, molecules responsible absorption were still elusive. Here, we focused on Cubam (Cubilin-Amnionless) as receptor involved absorption,...
Abstract Nutrient transfer from mother to the embryo is essential for reproduction in viviparous animals. In teleost Xenotoca eiseni belonging family Goodeidae, intraovarian intakes maternal component secreted into ovarian fluid via trophotaenia. Our previous study reported that epithelial layer cells of trophotaenia incorporate a protein vesicle trafficking. However, molecules responsible absorption were still elusive. Here, we focused on Cubam ( Cub ilin- Am nionless) as receptor involved...
ABSTRACT Gene regulatory networks that act upstream of skeletal muscle fate determinants are distinct in different anatomical locations. Despite recent efforts, a clear understanding the cascade events underlying emergence and maintenance stem cell pool specific groups remains unresolved debated. Here, we invalidated Pitx2 with multiple Cre -driver mice prenatally, postnatally, during lineage progression showed this gene becomes progressively dispensable for specification extraocular (EOM)...