A5009016743- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Bone health and treatments
- Bone Tissue Engineering Materials
- Hip and Femur Fractures
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Dental Implant Techniques and Outcomes
- Bone and Dental Protein Studies
- Connective tissue disorders research
- Trauma and Emergency Care Studies
- Dental Trauma and Treatments
- Bone and Joint Diseases
- Ion-surface interactions and analysis
- TGF-β signaling in diseases
- Health and Medical Research Impacts
- Magnesium Alloys: Properties and Applications
- Meta-analysis and systematic reviews
- Neurofibromatosis and Schwannoma Cases
- Electrospun Nanofibers in Biomedical Applications
- Dental Radiography and Imaging
- Vitamin D Research Studies
- Mesenchymal stem cell research
University of Giessen
2016-2025
University of Jordan
2024
Universitätsklinikum Gießen und Marburg
2013-2022
University of Oslo
2022
University of Bremen
2017
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2010-2012
Berlin-Brandenburger Centrum für Regenerative Therapien
2010-2012
German Rheumatism Research Centre
2010
Charité - Universitätsmedizin Berlin
2010
Abstract Fracture healing is a unique biologic process starting with an initial inflammatory response. As in other regenerative processes, bone and the immune system interact closely during fracture healing. This project was aimed at further elucidating how host participates A standard closed femoral created wild-type (WT) recombination activating gene 1 knockout (RAG1−/−) mice lacking adaptive system. Healing investigated using micro–computed tomography (µCT), biomechanical testing,...
The first objective was to investigate new bone formation in a critical-size metaphyseal defect the femur of ovariectomized rats filled with strontium modified calcium phosphate cement (SrCPC) compared (CPC) and empty defects. Second, detection release from materials as well collagen mass distribution fracture should be targeted by time flight secondary ion spectrometry (TOF-SIMS). 45 female Sprague-Dawley were randomly assigned three different treatment groups: (1) SrCPC (n = 15), (2) CPC...
Bone is a unique organ able to regenerate itself after injuries. This regeneration requires the local interplay between different biological systems such as inflammation and matrix formation. Structural reconstitution initiated by an inflammatory response orchestrated host immune system. However, individual role of T cells B in their relationship bone tissue remain unknown. Comparing fracture healing animals with without mature revealed essential these determining mineralization thus...
Bone histomorphometry allows quantitative evaluation of bone micro-architecture, formation, and remodeling by providing an insight to cellular changes. Histomorphometry plays important role in monitoring changes properties because systemic skeletal diseases like osteoporosis osteomalacia. Besides, fracture healing studies explore the effect biomaterial or drug treatment. However, until today, our knowledge, remain time-consuming expensive. This incited us set up open-source freely available...
Tibia trabeculae and vertebrae of rats as well human femur were investigated by high-resolution TEM at the atomic scale in order to reveal snapshots morphogenetic processes local bone ultrastructure formation. By taking into account reflections hydroxyapatite for Fourier filtering appearance individual alpha-chains within triple-helix clearly shows that bears feature an intergrowth composite structure extending from nanoscale, thus representing a molecular collagen apatite. Careful analysis...
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a well-established technique in material sciences but has not yet been widely explored for implementation life sciences. Here, we demonstrate the applicability and advantages of ToF-SIMS analysis study minerals biomolecules osseous tissue. The locally resolved fragment ions deriving from sample surface enables imaging differentiation bone tissue facilitates histology on non-stained cross sections. In rat model, bilateral...
Today, substantial attention is given to biomaterial strategies for bone regeneration, and among them, there a growing interest in using immunomodulatory biomaterials. The ability of induce neo vascularization macrophage polarization major factor defining its success. Magnesium (Mg)-based degradable alloys have attracted significant regeneration owing their biodegradability potential avoiding secondary removal surgeries. However, insufficient evidence the literature regarding early...
Many postmenopausal women have vitamin D and calcium deficiency. Therefore, supplementation is recommended for all patients with osteopenia osteoporosis. We used an experimental rat model to test the hypothesis that induction of osteoporosis more efficiently achieved in peripheral bone through combining ovariectomy a unique multi-deficiencies diet (vitamin depletion deficient calcium, K phosphorus). 14-week-old Sprague-Dawley rats served as controls examine initial status. 11 were...
Summary Osteoporosis is one of the deleterious side effects long‐term glucocorticoid therapy. Since condition particularly aggressive in postmenopausal women who are on steroid therapy, this study we have attempted to analyse combined effect (dexamethasone) treatment and cessation oestrogen rat bone. The dual aim was generate osteoporotic bone status a short time scale characterise combination glucocorticoid–postmenopausal conditions. Sprague Dawley rats ( N = 42) were grouped randomly into...
Bone fragility due to osteopenia, osteoporosis or debilitating focal skeletal dysplasias is a frequent observation in the Mendelian disease Neurofibromatosis type 1 (NF1). To determine mechanisms underlying bone NF1 we analyzed two conditional mouse models, Nf1Prx1 (limb knock-out) and Nf1Col1 (osteoblast specific knock-out), as well cortical samples from individuals with NF1. We examined tissue micro-computed tomography, qualitative quantitative histology, mechanical tensile analysis,...
In order to better understand the multifactorial nature of osteoporosis, animal models are utilized and compared healthy controls. Female sheep well established as a model for osteoporosis induced by ovariectomy, calcium vitamin D low diet, application steroids, or combination these treatments. Transcriptional studies can be performed applying quantitative real time PCR (RT-qPCR). RT-qPCR estimates mRNA-levels target genes in relation reference genes. A chosen set should not show variation...
Background and Objectives: he treatment of large bone defects in geriatric patients often presents a major surgical challenge because age-related loss. In such patients, the scarcity healthy makes autologous grafting techniques hard to perform. On one hand, clinicians’ fear possible infections limits using substitute materials (BSM). other BSM is limitless spares another surgery harvest material. Materials Methods: To address aptness we performed retrospective analysis all over age 64 years...
Summary Wnt/β‐catenin signalling components was shown to affect bone cells function including chondrocytes.Secreted Dkk1, a potent osteogenesis inhibiting factor mediates loss in diseased bones by suppressing the biological actions of Wnt proteins. In addition, increased Dkk1 inhibits chondrogenesis new formation. Recent findings also show there exists cross‐talk between chondrocytes and osteoblast lineage, which are most affected cell types muskuloskeletal disorders. This study investigated...