A5080019211- Bone health and osteoporosis research
- Ultrasonics and Acoustic Wave Propagation
- Ultrasound Imaging and Elastography
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Photoacoustic and Ultrasonic Imaging
- Elasticity and Material Modeling
- Bone fractures and treatments
- Ultrasound and Hyperthermia Applications
- Lower Extremity Biomechanics and Pathologies
- Bone and Joint Diseases
- Tendon Structure and Treatment
- Medical Imaging Techniques and Applications
- Orthopedic Infections and Treatments
- Hip and Femur Fractures
- Advanced X-ray Imaging Techniques
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Bone Metabolism and Diseases
- Cellular Mechanics and Interactions
- Hip disorders and treatments
- Dental Implant Techniques and Outcomes
- Rock Mechanics and Modeling
- Collagen: Extraction and Characterization
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2019-2025
Freie Universität Berlin
2019-2025
Berlin-Brandenburger Centrum für Regenerative Therapien
2015-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2011-2022
Czech Technical University in Prague
2020
Czech Academy of Sciences, Institute of Thermomechanics
2020
Martin Luther University Halle-Wittenberg
2004-2013
European Synchrotron Radiation Facility
2013
Schmerzmedizin Berlin
2010
ABSTRACT In bone remodeling, maturation of the newly formed osteonal tissue is associated with a rapid primary increase followed by slower secondary mineralization. This requires supply and precipitation mineral into matrix. Mineral delivery can occur only from extracellular fluid via interfaces such as Haversian system osteocyte pore network. We hypothesized that in mineralization, exchange achieved diffusion lacunar-canalicular network (LCN) to matrix, resulting gradual change...
A simple technique for the determination of spatial and temporal transmit-receive field distributions spherically focused high-frequency transducers is described. Instead a point-like target, tungsten wires (line-like targets) with diameters less than acoustic wavelength are used as pulse-echo targets. Spatial quantities were determined in frequency range from 3 to 17 MHz, comparison hydrophone measurements showed that both techniques yielded comparable results low-frequency transducer....
Chemical composition and fibrillar organization are the major determinants of osteonal bone mechanics. However, prominent methodologies commonly applied to investigate mechanical properties on micro scale usually not able concurrently describe both factors. In this study, we used polarized Raman spectroscopy (PRS) simultaneously analyze structural chemical information collagen fibrils in human a single experiment. Specifically, three-dimensional arrangement lamellae was assessed. By...
200 MHz acoustic impedance maps and site-matched synchrotron radiation micro computed tomography (SR-μCT) of tissue degree mineralization bone (DMB) were used to derive the elastic coefficient c33 in cross sections human cortical bone. To accomplish this goal, a model was developed relate DMB accessible with SR-μCT mass density. The formulation incorporates volume fractions densities major components (collagen, mineral water), accounts for porosity. We found that density can be well modelled...
The elastic properties of bone tissue determine the biomechanical behavior at organ level. It is now widely accepted that nanoscale structure plays an important role to Hence, in addition mineral density, and organization nanoparticles collagen microfibrils appear as potential key factors governing elasticity. Many studies exist on microfibril nanocrystals strongly remodeled bone. However, there no direct experimental proof support theoretical calculations. Here, we provide such evidence...
200 MHz scanning acoustic microscopy (SAM) and synchrotron radiation μCT (SR-μCT) were used to assess microstructural parameters tissue properties in site-matched regions of interest cortical bone. Anterior postero-lateral ten cross sections from human radius explored. Structural parameters, including diameter number Haversian canals per area (Ca.Dm, N.Ca/Ar) porosity Po assessed with both methods using a custom-developed image fusion analysis software. Acoustic impedance Z degree...
Osteonecrosis of the jaw, in association with bisphosphonates (BRONJ) used for treating osteoporosis or cancer, is a severe and most often irreversible side effect whose underlying pathophysiological mechanisms remain largely unknown. Osteocytes are involved bone remodeling mineralization where they orchestrate delicate equilibrium between osteoclast osteoblast activity through active process called osteocytic osteolysis. Here, we hypothesized that (i) changes mineralized tissue matrix play...
Assessment of anisotropic elastic properties at the tissue level is still one major challenges in bone research. In previous studies, sections were cut different directions relative to a principle axis symmetry. This causes high preparation and measurement effort. We have developed new acoustic scanning procedure that allows measure angular dependence impedance cylindrically shaped samples (diameter: 4.4 mm) with single measurement. Our microscope was equipped rotational stage, measures...
The increasing spectrum of different cartilage repair strategies requires the introduction adequate nondestructive methods to analyse their outcome in-vivo, i.e. arthroscopically.The validity non-destructive quantitative ultrasound biomicroscopy (UBM) was investigated in knee joints five miniature pigs.After 12 weeks, six 5-mm defects, treated with approaches, provided tissues structural qualities.Healthy articular from each contralateral unoperated joint served as a control.The reflected...
Alterations of structure and density cortical bone are associated with fragility fractures can be assessed in vivo humans at the tibia. Bone remodeling deficits aging women have been recently linked to an increase size pores. In this ex study, we characterized microarchitecture 19 tibiae from human donors (aged 69 94 years) address, whether reflect impairments mechanical competence proximal femur, i.e., a major fracture site osteoporosis. Scanning acoustic microscopy (12 μm pixel size)...