A5079591679- Bone health and osteoporosis research
- Ultrasound Imaging and Elastography
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Lower Extremity Biomechanics and Pathologies
- Ultrasonics and Acoustic Wave Propagation
- Photoacoustic and Ultrasonic Imaging
- Total Knee Arthroplasty Outcomes
- Ultrasound and Hyperthermia Applications
- Bone fractures and treatments
- Elasticity and Material Modeling
- Infrared Thermography in Medicine
- Bone and Joint Diseases
- Asphalt Pavement Performance Evaluation
- Thermoregulation and physiological responses
- Knee injuries and reconstruction techniques
- Reliability and Agreement in Measurement
- Ergonomics and Musculoskeletal Disorders
- Medical Imaging and Analysis
- Ultrasound and Cavitation Phenomena
- Hip and Femur Fractures
- Geophysical Methods and Applications
- Tendon Structure and Treatment
- Cardiac Valve Diseases and Treatments
University of Eastern Finland
2010-2018
Finland University
2014-2017
Kuopio University Hospital
2010-2013
The current contrast agents utilized in ultrasound (US) imaging are based on microbubbles which suffer from a short lifetime systemic circulation. present study introduces new type of agent for US bioresorbable Janus nanoparticles (NPs) that able to generate situ under radiation extended time. NPs porous silicon (PSi) was modified via nanostopper technique. technique exploited prepare PSi had hydrophobic pore walls (inner face), while the external surfaces (outer face) were hydrophilic. As...
The objective of the study was to investigate effects bariatric surgery-induced weight loss on knee gait and cartilage degeneration in osteoarthritis (OA) by combining magnetic resonance imaging (MRI), analysis, finite element (FE) modeling, algorithm. Gait analyses were performed for obese subjects before one-year after surgery. FE models created those who did not have severe tibio-femoral loss. Knee degenerations predicted using an adaptive algorithm which is based cumulative overloading...
Purpose: The purpose of this study was to investigate the effect simultaneous changes in cortical porosity, tissue mineral density, and elastic properties on radial speed sound (SOS) bone. authors applied quantitative pulse-echo (PE) ultrasound techniques that hold much potential especially for screening osteoporosis at primary healthcare facilities. Currently, most PE measurements thickness, a well-known indicator fracture risk, use predefined estimate SOS bone calculate thickness. Due...
Degenerative joint conditions are often characterized by changes in articular cartilage and subchondral bone properties. These associated with plate thickness trabecular morphology. Thus, evaluating integrity could provide essential insights for diagnosis of pathologies. This study investigates the potential optical spectroscopy characterizing human Osteochondral samples (n = 50) were extracted from cadaver knees 13) at four anatomical locations subjected to NIR spectroscopy. The then imaged...
Introduction. Musculoskeletal symptoms related to using traditional computer workstations are common. Quantitative methods for measuring muscle stress and strain needed improve ergonomics of workstations. We hypothesize that infrared thermography (IRT) is suited this purpose. Methods. This hypothesis was evaluated by estimating activity in upright working postures with IRT surface electromyography (sEMG). sEMG measurements were conducted 14 female participants both postures. First, the...
A rapidly growing area of interest in quantitative ultrasound assessment bone is to determine cortical porosity from backscatter. Current backscatter analyses are based on numerical simulations, while there no published reports successful experimental measurements. In this study, multivariate analysis applied reflections and predict porosity. The then estimate radial speed sound (SOS) thickness using signals obtained at 2.25 5 MHz center frequencies samples (n = 43) extracted femoral...
Abstract The histomorphometric properties of the subtrochanteric femoral region have rarely been investigated. aim this study was to investigate age‐associated variations and regional differences osteocytic in cortical bone shaft, association between histological parameters. Undecalcified sections shaft were obtained from cadavers ( n = 20, aged 18–82 years, males). They cut stained using modified Masson‐Goldner stain. Histomorphometric parameters analysed with ×50 ×100 magnification after...
Trabecular bone samples are traditionally embedded and polished for scanning acoustic microscopy (SAM). The effect of sample processing, including dehydration, on the impedance is unknown. In this study, human trabecular (n = 8) was experimentally assessed before (fresh) after embedding using SAM two-dimensional (2-D) finite-difference time domain simulations. Fresh were with sandpapers different grit (P1000, P2500, P4000). Experimental results indicated that increased significantly [mean...
The potential of quantitative ultrasound (QUS) to assess the regular cellular spacing in superficial cartilage zones was investigated experimentally and numerically. Nine osteochondral samples, extracted from two human cadaver knee joints, were measured using a 50-MHz scanning device evaluated Mankin score. Simulated backscattered power spectra models with an idealized cell alignment exhibited pronounced frequency peak. From peak, range between 15 40 μm layers detected average error 0.2 μm....
In pulse-echo (PE) ultrasound measurements, the use of focused transducers is desirable for quantitative assessment bone characteristics because attenuation in overlying soft tissues. However, variable thickness and composition tissue affect focal depth beam induce errors into measurements. To compensate attenuation-related effects caused by interfering (i.e., fat lean tissue), a dual-frequency (DFUS) technique was recently introduced. The aim this study to investigate effect non-optimal on...
Knowledge about simultaneous contributions of tissue microstructure and elastic properties on ultrasound speed in cortical bone is limited. In a previous study, porosities coefficients human femurs were shown to change with age. the present influences inter-individual site-dependent variation radial sound (SOS; at 4, 6, 8 MHz) investigated using three-dimensional (3D) finite difference time domain modeling. Models fixed (nominal model) sample-specific (sample-specific values compared....
Overlying soft tissues attenuate ultrasound backscattered from bone, complicating diagnostics of osteoporosis at the most important fracture sites. Dual-frequency technique (DFUS) has been proposed to solve this problem through determination thickness and composition overlying tissue. This study applies DFUS for first time with a phased-array transducer investigate if two interfering layers (oil water) can be accurately determined in variety configurations. Results indicate that may used...
Measurement of ultrasound backscattering is a promising diagnostic technique for arthroscopic evaluation articular cartilage. However, contribution collagen and chondrocytes on speed sound in cartilage not fully understood experimentally difficult to study. Agarose hydrogels have been used tissue engineering applications Therefore, the aim this study was simulate propagation high frequency (40 MHz) agarose scaffolds with varying concentrations (1 32 × 10(6) cells/ml) (1.56-200 mg/ml) using...
Diagnosis of osteoporosis is made at skeletal sites composed mainly trabecular bone. Calcaneus has been the first location for through transmission (TT) ultrasonic measurements Similarly as with DXA, best prediction hip fractures could be obtained by making hip. To realize axial pulse-echo (PE) ultrasound measurements, e.g., in we have introduced dual frequency (DFUS) technique to minimize effects soft tissues overlying bone and correct PE-parameters [Riekkinen et al., Ultrasound Med. Biol....
Tissue level structure and mechanical properties are important determinants of macroscopic bone strength. Scanning acoustic microscopy (SAM) provides maps local elasticity in bone. The present aims were to evaluate spatial variations elastic structural human femoral neck shaft, their with age. A total 48 transverse cross-sectional samples obtained from (Fn) proximal shaft (Ps) 24 cadavers (21 men, 4 women; age 49.2±16.3 years). Samples measured a custom SAM using 50-MHz ultrasound...