A5082522407- Silicon Nanostructures and Photoluminescence
- Nanowire Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Quantum Dots Synthesis And Properties
- Laser-Ablation Synthesis of Nanoparticles
- Ultrasound and Cavitation Phenomena
- Graphene and Nanomaterials Applications
- Anodic Oxide Films and Nanostructures
- Photoacoustic and Ultrasonic Imaging
- Carbon Nanotubes in Composites
- Luminescence Properties of Advanced Materials
- Photodynamic Therapy Research Studies
- Nanoparticles: synthesis and applications
- Microfluidic and Bio-sensing Technologies
- Digital Radiography and Breast Imaging
- Infrared Thermography in Medicine
- bioluminescence and chemiluminescence research
- Bone Tissue Engineering Materials
Lomonosov Moscow State University
2013-2024
Clinics Hospital of Ribeirão Preto
2017
Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF) radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively target cells thus avoid side effects. Here, we assess crystalline silicon (Si) based nanomaterials as the RF-induced therapy. Using nanoparticles produced by mechanical grinding of porous ultraclean laser-ablative synthesis, report heating aqueous suspensions temperatures above 45-50°C under relatively low...
Aqueous suspensions of porous silicon nanoparticles (NPs) with average size ∼100 nm and concentration ∼1 g/L undergo significant heating as compared pure water under therapeutic ultrasonic (US) irradiation frequencies 1–2.5 MHz intensities 1–20 W/cm2. This effect is explained by taking into account the efficient absorption US energy NPs. The observed US-induced biodegradable NPs promising for applications in hyperthermia tumors.
Abstract Silicon nanoparticles (SiNPs) obtained by mechanical grinding of porous silicon have been used for visualization living cells in vitro . It was found that SiNPs could penetrate into the without any cytotoxic effect up to concentration 100 μg/ml. The cell cytoplasm observed be filled SiNPs, which exhibited bright photoluminescence at 1.6 eV. also act as photosensitizers singlet oxygen generation, photodynamic therapy cancer. These properties are discussed view possible applications...
A significant decrease of the cavitation threshold in aqueous suspensions porous silicon nanoparticles (PSi NPs) with sizes about 100 nm as compared pure water was observed for ultrasound irradiation (USI) therapeutic frequency (0.88 MHz) and intensities (about 1 W/cm2). This effect is explained by morphology PSi NPs, which promotes nucleation bubbles. In vitro experiments revealed a suppression proliferation cancer cells introduced NPs after exposure to USI related enhanced processes, led...
Silicon nanoparticles (SiNPs) prepared by mechanical grinding of luminescent porous silicon were coated with a biopolymer (dextran) and investigated as potential theranostic agent for bioimaging sonodynamic therapy. Transmission electron microscopy, photoluminescence Raman scattering measurements dextran-coated SiNPs gave evidence their enhanced stability in water. In vitro experiments confirmed the lower cytotoxicity NPs comparison uncoated ones, especially high concentrations about 2 mg...
The current contrast agents utilized in ultrasound (US) imaging are based on microbubbles which suffer from a short lifetime systemic circulation. present study introduces new type of agent for US bioresorbable Janus nanoparticles (NPs) that able to generate situ under radiation extended time. NPs porous silicon (PSi) was modified via nanostopper technique. technique exploited prepare PSi had hydrophobic pore walls (inner face), while the external surfaces (outer face) were hydrophilic. As...
As-prepared mesoporous silicon nanoparticles, which were synthesized by electrochemical etching of crystalline wafers followed high-energy milling in water, explored as a sonosensitizer aqueous media under irradiation with low-intensity ultrasound at 0.88 MHz. Due to the mixed oxide-hydride coating nanoparticles’ surfaces, they showed both acceptable colloidal stability and sonosensitization acoustic cavitation. The latter was directly measured quantified cavitation energy index, i.e., time...
The presence of nanoparticles lowers the levels ultrasound (US) intensity needed to achieve therapeutic effect and improves contrast between healthy pathological tissues. Here, we evaluate role two main mechanisms that contribute US-induced heating aqueous suspensions biodegradable (NPs) mesoporous silicon prepared by electrochemical etching heavily boron-doped crystalline wafers in a hydrofluoric acid solution. first mechanism is associated with an increase attenuation US NPs due additional...
The effects of ultrasonic cavitation and heat deposition in aqueous suspensions mesoporous silicon nanoparticles were experimentally investigated using an original setup enabling precise temperature control registration by harmonics analysis the transmitted signal. obtained results reveal significant lowering thresholds heating as compared to pure water.
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This study investigates the use of photoluminescent amphiphilic porous silicon nanoparticles (αϕ-pSiNPs) as effective ultrasound (US) amplifiers for cancer sonodynamic theranostics. αϕ-pSiNPs were synthesized via a novel top-down approach involving (pSi) films electrochemical etching, borate oxidation, and hydrophobic coating with octadecylsilane (C18), resulting in milling into hydrophilic exteriors interiors. These properties promote gas trapping cavitation nucleation, significantly...