Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF) radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively target cells thus avoid side effects. Here, we assess crystalline silicon (Si) based nanomaterials as the RF-induced therapy. Using nanoparticles produced by mechanical grinding of porous ultraclean laser-ablative synthesis, report heating aqueous suspensions temperatures above 45-50°C under relatively low...

An ultrashort laser-assisted method for fast production of concentrated aqueous solutions ultrapure Si-based colloidal nanoparticles is reported. The profits from the 3D geometry femtosecond laser ablation water-dispersed microscale colloids, prepared preliminarily by mechanical milling a Si wafer, in order to avoid strong concentration gradients ablated material and provide similar conditions nanocluster growth within relatively large caustics volume. We demonstrate possibility synthesis...

Abstract Crystalline silicon (Si) nanoparticles present an extremely promising object for bioimaging based on photoluminescence (PL) in the visible and near-infrared spectral regions, but their efficient PL emission aqueous suspension is typically observed after wet chemistry procedures leading to residual toxicity issues. Here, we introduce ultrapure laser-synthesized Si-based quantum dots (QDs), which are water-dispersible exhibit bright exciton window of relative tissue transparency near...

Abstract Silicon nanoparticles (SiNPs) obtained by mechanical grinding of porous silicon have been used for visualization living cells in vitro . It was found that SiNPs could penetrate into the without any cytotoxic effect up to concentration 100 μg/ml. The cell cytoplasm observed be filled SiNPs, which exhibited bright photoluminescence at 1.6 eV. also act as photosensitizers singlet oxygen generation, photodynamic therapy cancer. These properties are discussed view possible applications...

Small (3−5 nm in diameter following HRTEM images) Si nanocrystals were produced a two-stage process including (1) nanosecond laser ablation of target an organic liquid (chloroform) that results formation big composite polycrystalline particles (about 20−100 average diameter) and (2) ultrasonic post-treatment nanoparticles the presence HF. The is responsible for disintegration particles, release small individual nanocrystals, reduction their size due to HF-induced etching oxide. downshift...

Silicon nanoparticles (SiNPs) prepared by mechanical grinding of luminescent porous silicon were coated with a biopolymer (dextran) and investigated as potential theranostic agent for bioimaging sonodynamic therapy. Transmission electron microscopy, photoluminescence Raman scattering measurements dextran-coated SiNPs gave evidence their enhanced stability in water. In vitro experiments confirmed the lower cytotoxicity NPs comparison uncoated ones, especially high concentrations about 2 mg...

We propose porous silicon nanoparticles (PSi NPs) with natural oxide coating as biocompatible and bioresorbable contrast agents for magnetic resonant imaging (MRI). A strong shortening of the transversal proton relaxation time (T2) was observed aqueous suspensions PSi NPs, whereas longitudinal (T1) changed moderately. The relaxivities are estimated to be 0.03 0.4 l/(g·s), respectively, which promising biomedical studies. is suggested undergo via dipole-dipole interaction Si dangling bonds on...

A significant enhancement of the photoluminescence (PL) efficiency is observed for aqueous suspensions porous silicon nanoparticles (PSiNPs) coated by bioresorbable polymers, i.e., polylactic-co-glycolic acid (PLGA) and polyvinyl alcohol (PVA). PSiNPs with average size about 100 nm prepared mechanical grinding electrochemically etched were dispersed in water to prepare stable suspension. The inner hydrophobic PLGA layer prevents from dissolution water, while outer PVA makes hydrophilic. PL...

New approaches for visualisation of silicon nanoparticles (SiNPs) in cancer cells are realised by means the linear and nonlinear optics vitro. Aqueous colloidal solutions SiNPs with sizes about 10–40 nm obtained ultrasound grinding nanowires were introduced into breast (MCF-7 cell line). Further, time-varying enclosed structures visualised high-resolution structured illumination microscopy (HR-SIM) micro-Raman spectroscopy. Additionally, optical methods two-photon excited fluorescence (TPEF)...

We propose a rapid, one-pot method to generate photoluminescent (PL) mesoporous silicon nanoparticles (PSiNPs). Typically, (meso-PSi) films, obtained by electrochemical etching of monocrystalline substrates, do not display strong PL because the nanocrystals (nc-Si) in skeleton are generally too large quantum confinement effects. Here we describe an improved approach form PSiNPs from meso-PSi partial oxidation aqueous sodium borate (borax) solutions. The borax solution acts simultaneously...

Bilirubin (BR) is a product of hemoglobin breakdown, and its increasing levels in the blood may indicate liver disorders lead to jaundice. Kernicterus most dangerous newborns when unconjugated BR concentration can quickly rise toxic levels, causing neurological damage even death. The development an accurate, fast, sensitive sensor for detection will help reduce diagnostic time ensure successful treatment. In this study, we propose new method creating surface-enhanced Raman scattering...

Silicon nanowires (SiNWs) formed by metal(silver)-assisted chemical etching of lowly boron-doped (100)-oriented single crystalline silicon substrates in hydrofluoric acid solutions are investigated means the electron microscopy and optical spectroscopy (absorption reflection measurements, photoluminescence imaging). The growth rate SiNWs is found to depend nonlinearly on time etching. SiNW arrays demonstrate a strong decrease total reflectance below 1% full visible near infrared region...

The formation of photoluminescent porous silicon (PSi) nanoparticles (NPs) is usually based on an expensive semiconductor grade wafers technology. Here, we report a low-cost method PSi NPs synthesis from the industrial waste remained after wafer production. proposed metal-assisted wet-chemical etching (MACE) surface cm-sized metallurgical stones which leads to nanostructuring due anisotropic etching, with subsequent ultrasound fracturing in water. obtained exhibit bright red room temperature...

We report new sensing element based on double-etched porous silicon (DEPSi) for sensitive detection of influenza viruses (H1N1). The proposed structure provided efficient penetration virions into layer and trapping them. Adsorption the led to significant shift resonant frequency DEPSi coupled with a coil, measured by impedance spectrometer. limit was lower than 100 TCID50. results can be used invention H1N1 sensor, which provide rapid, label-free low-cost influenza.

The efficiency of light scattering by nanoparticles formed using the method picosecond laser ablation silicon in water and mechanically grinded mesoporous is compared. ensembles particles both types possess coefficients sufficient to use them as contrast agents optical coherence tomography (OCT), particularly range wavelengths 700 – 1000 nm, where absorption most biological mimicking tissues small. According Mie theory main contribution this case made having a relatively large size (150 300...

The radiofrequency (RF) mild hyperthermia effect sensitized by biodegradable nanoparticles is a promising approach for therapy and diagnostics of numerous human diseases including cancer. Herein, we report the significant enhancement local destruction cancer cells induced RF in presence degraded low-toxic porous silicon (PSi) nanowires (NWs). Proper selection irradiation time (10 min), intensity, concentration PSi NWs, incubation (24 h) decreased cell viability to 10%, which can be...

Photosensitization of singlet oxygen generation in porous silicon (PSi) was investigated by simultaneous measurements the photoluminescence (PL) nanocrystals (nc-Si) and infrared emission 1Δ-state molecules at 1270 nm (0.98 eV) room temperature. Photodegradation nc-Si PL properties found to correlate with efficiency generation. The quantum PSi estimated be about 1%, while lifetime fifteen ms. kinetics intensity under cw excitation undergoes a power law dependence exponent dependent on photon...

Nanomaterials are a central pillar in modern medicine. They thought to optimize drug delivery, enhance therapeutic efficacy, and reduce side-effects. To foster this technology, analytical methods needed validate not only the localization distribution of these nanomaterials, but also their compatibility with cells, drugs, release. In present work, we assessed nanoparticles based on porous silicon (pSiNPs) loaded clinically used tyrosine kinase inhibitor sunitinib for effectiveness release,...

Silicon nanoparticles (SiNP) are currently of great interest, especially in biomedicine, because their unique physicochemical properties combined with biodegradability. SiNPs can be obtained various ways and have either a non-porous solid (sol-) or porous (por-) structure. In this work, we carry out detailed optical monitoring sol- por-SiNP biodegradation using Raman photoluminescence (PL) micro-spectroscopy. were by ultrasound grinding por-silicon nanowires, created silver-assisted chemical...