A5023643620- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Medical Imaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Traumatic Brain Injury and Neurovascular Disturbances
- Nanoparticle-Based Drug Delivery
- Electron Spin Resonance Studies
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Anesthesia and Neurotoxicity Research
- Nanoplatforms for cancer theranostics
- Neonatal and fetal brain pathology
- Connexins and lens biology
- Coenzyme Q10 studies and effects
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginseng Biological Effects and Applications
- Redox biology and oxidative stress
Lomonosov Moscow State University
2015-2024
Moscow State University
2012-2024
Siberian Transport University
2024
All-Russian Research Institute of Reclaimed Lands
2017
Clinical Hospital No. 8
2016
Prokhorov General Physics Institute
2010
Russian Cancer Research Center NN Blokhin
2010
We explored the neuroprotective properties of natural plant-derived antioxidants plastoquinone and thymoquinone (2-demethylplastoquinone derivative) modified to be specifically accumulated in mitochondria. The modification was performed through chemical conjugation quinones with penetrating cations: Rhodamine 19 or tetraphenylphosphonium. Neuroprotective were evaluated a model middle cerebral artery occlusion. demonstrate that mitochondria-targeted compounds, introduced immediately after...
We propose porous silicon nanoparticles (PSi NPs) with natural oxide coating as biocompatible and bioresorbable contrast agents for magnetic resonant imaging (MRI). A strong shortening of the transversal proton relaxation time (T2) was observed aqueous suspensions PSi NPs, whereas longitudinal (T1) changed moderately. The relaxivities are estimated to be 0.03 0.4 l/(g·s), respectively, which promising biomedical studies. is suggested undergo via dipole-dipole interaction Si dangling bonds on...
Neonatal hypoxia⁻ischemia is one of the main causes mortality and disability newborns. To study mechanisms neonatal brain cell damage, we used a model in seven-day-old rats, by annealing common carotid artery with subsequent hypoxia 8% oxygen. We demonstrate that mitochondrial dysfunction associated high production reactive oxygen species, which leads to oxidative stress. Targeted delivery antioxidants mitochondria can be an effective therapeutic approach treat deleterious effects...
In orbital and ground-based experiments, it has been demonstrated that ionizing radiation (IR) can stimulate the locomotor exploratory activity of rodents, but underlying mechanism this phenomenon remains undisclosed. Here, we studied effect combined IR (0.4 Gy γ-rays 0.14 carbon-12 nuclei) on rats, assessed sensorimotor cortex volume by magnetic resonance imaging-based morphometry at 1 week 7 months post-irradiation. The tissues were processed to determine whether behavioral morphologic...
Oxidative stress plays a key role in the pathogenesis of ischemic stroke. Coenzyme Q10 has multi-targeting effect and may protect brain against damage. The aim our study was to evaluate neuroprotective potential ubiquinol by its intravenous administration. performed on rats; stroke modeled occlusion middle cerebral artery. On days 1 4 after ischemia, neurological deficit volume lesion were determined MRI TTC staining. Intravenous administration coenzyme led decrease rat mortality rate,...
Purpose The aim of this study was to demonstrate the feasibility fluorine‐19 ( 19 F) MRI human lungs using octafluorocyclobutane (OFCB, C 4 F 8 ). This gas has magnetically equivalent fluorine nuclei and relatively long T 1 2 (˜50 ms), which render it suitable as an contrast agent. Previous experiments in small laboratory animals showed that OFCB could be successfully used alternative gases often for (sulfur hexafluoride perfluoropropane). Methods One male volunteer participated study....
Particular applications in preclinical magnetic resonance imaging require the entire body of an animal to be imaged with sufficient quality. This is usually performed by combining regions scanned small coils high sensitivity or long scans using large low sensitivity. Here, a metamaterial-inspired design employing parallel array wires operating on principle eigenmode hybridization was used produce small-animal coil. The coil field distribution responsible for view and simulated...
Silicon (Si) nanoparticles (NPs) with small (10 −3 –10 −1 at%) content of iron oxide (Fe 2 O 3 ) are prepared by plasma‐assisted ablative synthesis. Powders the Si‐iron (SIO) NPs investigated means transmission electron microscopy, Raman spectroscopy, paramagnetic resonance, and magnetic susceptibility measurements. Aqueous suspensions studied using dynamic light scattering nuclear resonance technique. The longitudinal transverse relaxation times protons in aqueous found to be dependent on...
The conventional targeted delivery of chemotherapeutic and diagnostic agents utilizing nanocarriers is a promising approach for cancer theranostics. Unfortunately, this often faces hindered tumor access that decreases the therapeutic index limits further clinical translation developing drug. Here, we demonstrated strategy simultaneously double-targeting drug to two distinct cites tissue: endothelium cell surface receptors. We used fourth-generation polyamideamine dendrimers modified with...
Ubiquinol exhibits anti-inflammatory and antioxidant properties. Selenium is a part of number enzymes. The monocrotaline inducible model pulmonary hypertension used in this study includes pathological links that may act as an application for the use ubiquinol with high bioavailability selenium metabolic products. On day 1, male female rats were subcutaneously injected water-alcohol solution or only solution. days 7 14, some animals intravenously either ubiquinol's vehicle solubilized...