A5086314494- Sinusitis and nasal conditions
- Neuroendocrine Tumor Research Advances
- Allergic Rhinitis and Sensitization
- Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Ear and Head Tumors
- Pancreatic and Hepatic Oncology Research
- Vascular Malformations and Hemangiomas
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Oral and Maxillofacial Pathology
- Inflammatory Bowel Disease
- Tracheal and airway disorders
- Infectious Diseases and Mycology
- Cancer Immunotherapy and Biomarkers
- Radiation Effects and Dosimetry
- Autoimmune and Inflammatory Disorders
- Vascular anomalies and interventions
- Ferroptosis and cancer prognosis
- Dysphagia Assessment and Management
- Soft tissue tumor case studies
- Thyroid Cancer Diagnosis and Treatment
Oregon Health & Science University
2012-2022
University of Missouri
2021
University of Missouri Hospital
2021
University of Southern California
2021
University of Kansas Medical Center
2021
University of California, Davis
2021
Hanover College
2014
Uppsala University
2014
Portland VA Medical Center
2001-2006
California Institute of Technology
2006
Here, we describe a multiplexed immunohistochemical platform with computational image processing workflows, including cytometry, enabling simultaneous evaluation of 12 biomarkers in one formalin-fixed paraffin-embedded tissue section. To validate this platform, used microarrays containing 38 archival head and neck squamous cell carcinomas revealed differential immune profiles based on lymphoid myeloid densities, correlating human papilloma virus status prognosis. Based these results,...
Assess whether the presence of mucosal eosinophilia correlates with surgical outcomes in patients chronic rhinosinusitis.Prospective cohort.Tertiary medical center.Adult rhinosinusitis were prospectively enrolled, and demographic data comorbidities recorded. Preoperative quality life (QOL) was measured by Chronic Sinusitis Survey (CSS), Rhinosinusitis Disability Index (RSDI), Short Form-36 General Health (SF-36). Sinus specimens collected at time surgery degree quantified. Postoperative QOL...
Describe detailed histopathologic findings from a cohort of patients with chronic rhinosinusitis and evaluate whether histologic measures correlate baseline clinical factors.Cross-sectional study planned data collection.Tertiary medical center.Adult were prospectively enrolled demographic comorbidities recorded. Disease severity was measured by computed tomography (CT), endoscopy, Smell Identification Test (SIT), the Chronic Sinusitis Survey, Rhinosinusitis Disability Index, SF-36 General...
Intratumoral phenotypic heterogeneity has been described in many tumor types, where it can contribute to drug resistance and disease recurrence. We analyzed ductal neuroendocrine markers pancreatic adenocarcinoma, revealing heterogeneous expression of the marker Synaptophysin within lesions. Higher percentages Cytokeratin-Synaptophysin dual positive cells correlate with shortened disease-free survival. observe similar lineage mouse models tracing indicates that arise from exocrine...
Abstract The importance of acetylcholine as a neurotransmitter in the nervous system is well established, but little yet known about its recently described role an autocrine and paracrine hormone wide variety nonneuronal cells. Consistent with expression normal lung, small cell lung carcinoma (SCLC) synthesize secrete acetylcholine, which acts growth factor through both nicotinic muscarinic cholinergic mechanisms. purpose this study was to determine if interruption signaling has potential...
OBJECTIVES A major limitation to screening and surveillance of Barrett's esophagus is the complexity, expense, risk associated with sedation for upper endoscopy. This study examines feasibility, accuracy, patient acceptability office-based unsedated endoscopy as an alternative. METHODS Of 274 eligible adults scheduled endoscopic gastroesophageal reflux symptoms or at a tertiary care center, 121 underwent small-caliber conventional in randomized crossover study. The two procedures were...
Background Histological inflammation correlates with the degree of baseline olfactory dysfunction in patients chronic rhinosinusitis (CRS); however, factors associated improvement status after endoscopic sinus surgery (ESS) remain elusive. Our purpose was to compare histopathological findings CRS loss and evaluate whether inflammatory markers can predict long-term ESS. Methods Adult (≥18 years) were prospectively enrolled electing ESS due failed medical management. Mucosal tissue specimens...
To determine the risk of nodal metastases to central compartment from differentiated papillary thyroid carcinoma (PTC) relative known prognostic variables.A 7-year single-institutional retrospective review.Tertiary academic center.A total 115 patients undergoing neck dissection (CND) for PTC or follicular variant (FVPTC).Number, location, and positivity lymph nodes malignant disease in based on patient age, sex, extrathyroidal extension, primary tumor size, histologic type,...
Papillary thyroid carcinoma (PTC) follows an indolent course; however, up to 30% of patients develop recurrent disease requiring further treatment. Profiling PTC immune complexity may provide new biomarkers for improved risk prediction.Immune profiles were quantitatively evaluated by multiplex immunohistochemistry (mIHC) in archived tissue sections from 39 with PTC, and assessed correlations aggressive histopathological features based on the presence lymphovascular invasion and/or...
OBJECTIVE. Lymphoceles are benign neck cysts that important to differentiate from congenital, infectious, and malignant cystic masses because they require unique surgical treatment follow-up. We reviewed a series of surgically proven lymphoceles delineate the radiologic characteristics them other masses.
Levels of circulating hybrid cells (CHCs), a newly identified tumor cell (CTC), correlate with disease stage and progression in cancer. We investigated their utility to risk-stratify patients clinically N0 (cN0) oral cavity squamous carcinoma (OCSCC), identify occult cervical lymph node metastases (pN+).We analyzed peripheral blood samples for CHCs co-expression cytokeratin (tumor) CD45 (leukocyte) from 22 cN0 OCSCC using immunofluorescence microscopy, then correlated levels pathologic...
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The digitization of radiographic studies along with high-speed transmission images has formed the basis teleradiology, which become an integral component in workflow a contemporary radiology practice. It is this advent and growing utilization teleradiology that significance source location gained importance. Specifically, importance where patient resides what endemic fungi occur cannot be underestimated. In United States, histoplasmosis, coccidioidomycosis, blastomycosis, cryptococcosis are...
Populations at risk for esophageal adenocarcinoma remain poorly defined. Laryngeal symptoms can be secondary to laryngopharyngeal reflux (LPR) and occur without associated gastroesophageal such as heartburn regurgitation.
Objectives: We report a case of acutely worsening allergic fungal sinusitis in patient receiving immunotherapy with pembrolizumab, programmed cell death protein 1 (PD-1) inhibitor. Methods: A 53-year-old man history metastatic melanoma and recent initiation pembrolizumab therapy presented headaches, left abducens nerve palsy, neuroimaging demonstrating an erosive skull base lesion bilateral cavernous sinus involvement. Results: Intraoperative findings were consistent non-invasive disease....
Background Chronic rhinosinusitis (CRS) is associated with sleep dysfunction, but the underlying pathophysiology poorly understood. The purpose of this study was to determine if mucosal eosinophilia or neutrophilia were dysfunction severity altered improvement in following functional endoscopic sinus surgery (FESS). Methods A total 104 patients medically refractory CRS nasal polyposis (CRSwNP) and without (CRSsNP), completed Pittsburgh Sleep Quality Index (PSQI) before after FESS. Anterior...
Abstract Background: Calcitriol, the natural ligand for vitamin D receptor, has significant potential in prostate cancer treatment. Measurement of its antineoplastic activity clinical trials may be complicated by effects calcitriol on prostate-specific antigen (PSA) production. We examined at similar concentration cell proliferation, androgen receptor (AR) expression, and PSA production vitro concentrations patients. Experimental Design: LNCaP proliferation was counts 6 days after exposure...
Chronic rhinosinusitis (CRS) is often differentiated by histopathologic phenotypes (eosinophilic versus neutrophilic), which may impact disease severity measures and outcomes. As such, it has been suggested that counts of cellular elements be included as part a standard pathological report following endoscopic sinus surgery (ESS).This cross-sectional study evaluated associations mucosal eosinophilia neutrophilia with quality-of-life (QoL) olfactory function.Patients medically refractory CRS...
Summary Hypoxia has been implicated as a stimulant of coagulation. As exertion is known to affect haemostasis, we sought control for this by using standardized protocol. Subjects were exercised both at room air and 12% oxygen. Exercise produced an increase in procoagulant factors, which was reduced with hypoxic exercise. Room exercise increased fibrinolytic markers. Hypoxic did not the tissue plasminogen activator, but decreased activator inhibitor‐1 expression. Thus, it appears that hypoxia...