A5017556292- Sinusitis and nasal conditions
- Olfactory and Sensory Function Studies
- Head and Neck Surgical Oncology
- Advanced Chemical Sensor Technologies
- Allergic Rhinitis and Sensitization
- Anesthesia and Pain Management
- Biochemical Analysis and Sensing Techniques
- Otitis Media and Relapsing Polychondritis
- Antifungal resistance and susceptibility
- Ear Surgery and Otitis Media
- Vascular Anomalies and Treatments
- Hearing Loss and Rehabilitation
- Chromatin Remodeling and Cancer
- Vagus Nerve Stimulation Research
- Neurosurgical Procedures and Complications
- Infectious Diseases and Mycology
- Pain Management and Opioid Use
- Obstructive Sleep Apnea Research
- Opioid Use Disorder Treatment
- Nasal Surgery and Airway Studies
- Bone Tumor Diagnosis and Treatments
- Vestibular and auditory disorders
- Foreign Body Medical Cases
- Infection Control and Ventilation
- IgG4-Related and Inflammatory Diseases
Washington University in St. Louis
2020-2025
Pioneer (United States)
2023
Oregon Health & Science University
2020-2022
University of Colorado Denver
2016-2020
Abstract Objective A novel COVID‐19 therapeutic, nirmatrelvir/ritonavir (Paxlovid), is commonly associated with reports of dysgeusia. The Food and Drug Administration Adverse Event Reporting System (FAERS) database was used to determine the real‐world reporting Paxlovid‐associated dysgeusia (PAD), identify factors, describe relative rates for Paxlovid compared other therapeutics (OCT), ritonavir alone, protease inhibitors (OPI). Study Design Observational retrospective. Setting Tertiary...
Recent studies suggest that theophylline added to saline nasal irrigation (SNI) can be an effective treatment for postviral olfactory dysfunction (OD), a growing public health concern during the COVID-19 pandemic.To evaluate efficacy and safety of SNI compared with placebo COVID-19-related OD.This triple-blinded, placebo-controlled, phase 2 randomized clinical trial was conducted virtually between March 15 August 31, 2021. Adults residing in Missouri or Illinois were recruited this time...
Atypical teratoid rhabdoid tumors (ATRTs) are typically aggressive pediatric with a median survival of 11 months. Due to the paucity cases in adults, clinical behavior these pathologies is not well understood. Here we present case 41-year-old female patient postoperative hyperprogression sellar ATRT and provide detailed description molecular composition this tumor, protocol used treat patient, ultimate outcome patient. The woman who presented headaches double vision. MRI revealed...
To determine if a short 10-minute video of either CT images (Video1: V1) or and endoscopic surgical videos (Video 2: V2) could be used to improve sinonasal anatomy knowledge in medical students (Med) otolaryngology residents (OtoR). YouTube is widely platform for training, yet many educational are poor quality. We developed validated two narrated sinus anatomy, the first (V1) incorporated critical structures while second (V2) combined video. In tandem, we assessment test landmarks,...
Abstract Background Readmission following endoscopic endonasal transsphenoidal surgery (EETS) for pituitary neuroendocrine tumor (PitNET) and other sellar pathology is most commonly due to delayed hyponatremia. Studies suggest post-operative fluid restriction (FR) reduces We present a prospective randomized controlled study evaluating post-EETS FR. Methods 300 participants were scheduled EETS (2016-2023) at single institution. Patients with CKD, CHF, arginine vasopressin deficiency on day...
Background Sinonasal squamous cell carcinoma (SNSCC) is a rare malignancy that poses management challenges. Although surgery and chemoradiation therapy (CRT) remain therapeutic mainstays, induction chemotherapy (IC) has emerged as useful adjunct with locally advanced disease. This study used the National Cancer Data Base (NCDB) to examine treatment outcomes for patients diagnosed SNSCC. Methods The NCDB (2004‐2015) was queried cases Multivariate hazard regression modeling identify...
Current tools for diagnosis of olfactory dysfunction (OD) are costly, time-consuming, and often require clinician administration.To develop validate a simple screening assessment OD using common household items.This fully virtual diagnostic study included adults with self-reported from any cause throughout the US. Data were collected December 2020 to April 2021 analyzed May July 2021.Participants took survey assessing smell perception 45 items completed Clinical Global Impression-Severity...
Drilling on the incus produces intracochlear pressure changes comparable to pressures created by high-intensity acoustic stimuli.New-onset sensorineural hearing loss (SNHL) following mastoid surgery can occur secondary inadvertent drilling ossicular chain. To investigate this, we test hypothesis that high sound levels are generated when a high-speed drill contacts incus.Human cadaveric heads underwent mastoidectomy, and fiber-optic sensors were placed in scala tympani vestibuli measure...
Abstract Objective The objective of this study was to explore the safety and feasibility stellate ganglion blocks (SGBs) treat persistent COVID‐19‐induced olfactory dysfunction (OD). Secondarily, goal determine effect sizes plan a future randomized clinical trial. Study Design Prospective case series. Setting Quaternary Care Academic Medical Center. Methods In single‐arm pilot trial, adult participants with COVID‐19 diagnosis ≥ 12 months prior enrollment OD underwent bilateral SGBs. Subjects...
Hypothesis: Intracochlear pressures (P IC ) and stapes velocity (V stap elicited by bilaterally placed bone-anchored hearing devices (BAHD) will be systematically modulated imposed interaural time (ITD) level differences (ILD), demonstrating the potential for users of bilateral BAHD to access these binaural cues. Background: are traditionally implanted unilaterally under assumption that transcranial cross-talk limits differences. Recent studies have demonstrated improvements in spatial...
Despite the aggressive progression of fulminant acute invasive fungal sinusitis (AIFS), data on prognostic factors have been disparate, hindering development a staging system. A composite system may improve prognostication for patient counseling and conduct clinical research.
Objective (1) Understand attitudes of otolaryngology residency applicants regarding gender and racial diversity within programs. (2) Examine how program affects applicant decisions during the match. (3) Compare importance ethnic among applicants. Study Design Web‐based survey distributed in February March 2019. Setting Tertiary care university setting. Subjects Methods An anonymous web‐based was to 418 2019 Respondents were queried about its effects on match process. Ratings based a scale 1...
Background Chronic rhinosinusitis (CRS) is associated with sleep dysfunction, but the underlying pathophysiology poorly understood. The purpose of this study was to determine if mucosal eosinophilia or neutrophilia were dysfunction severity altered improvement in following functional endoscopic sinus surgery (FESS). Methods A total 104 patients medically refractory CRS nasal polyposis (CRSwNP) and without (CRSsNP), completed Pittsburgh Sleep Quality Index (PSQI) before after FESS. Anterior...
Chronic rhinosinusitis (CRS) is often differentiated by histopathologic phenotypes (eosinophilic versus neutrophilic), which may impact disease severity measures and outcomes. As such, it has been suggested that counts of cellular elements be included as part a standard pathological report following endoscopic sinus surgery (ESS).This cross-sectional study evaluated associations mucosal eosinophilia neutrophilia with quality-of-life (QoL) olfactory function.Patients medically refractory CRS...
Background Inflammatory profiles for patients with chronic rhinosinusitis nasal polyposis (CRSwNP) vary between North American and Asian populations. An elevated ethmoid‐to‐maxillary (E/M) opacification ratio on preoperative imaging is associated certain postoperative outcomes in populations that are non‒type 2 dominant. In this study we explore factor American/type 2‒based Methods Adult (n = 165) from a population CRSwNP who underwent endoscopic sinus surgery (ESS) were prospectively...
Invasive fungal sinusitis (IFS) rate and risk factors in transplant recipients were explored IFS is higher allogeneic with prior transplants worse comorbidity scores The at-risk timeframes for development identified.
Abstract Objective Develop and validate a quality‐of‐life (QoL) outcome measure for patients with dysosmia. Study Design Cross‐sectional survey study. Setting Otolaryngology clinics, research registries, Facebook support groups. Methods A 59‐item pilot questions addressing parosmia concerns was developed using input from subjects clinical expertise Otolaryngologists. After item reduction, the Parosmia Olfactory Dysfunction Outcomes Rating ( DisODOR ) reduced to its final 29 items. maximum...