A5033981619- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Air Quality and Health Impacts
- Phonetics and Phonology Research
- Neurological Disease Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Biomarkers in Disease Mechanisms
- Stuttering Research and Treatment
- Tracheal and airway disorders
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience of respiration and sleep
- Retinal Development and Disorders
- COVID-19 and healthcare impacts
- Optical Imaging and Spectroscopy Techniques
- Respiratory and Cough-Related Research
- Climate Change and Health Impacts
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Speech Recognition and Synthesis
- Ginger and Zingiberaceae research
University of Minnesota
2024
University of Southern California
2020-2023
University of Washington
2023
Fondazione Audiologica Varese
2022
Canadian Thoracic Society
2022
Institute of Molecular and Cell Biology
2016
University of California, Berkeley
2015
The preBötzinger Complex (preBötC), a medullary network critical for breathing, relies on excitatory interneurons to generate the inspiratory rhythm. Yet, half of preBötC neurons are inhibitory, and role inhibition in rhythmogenesis remains controversial. Using optogenetics electrophysiology vitro vivo, we demonstrate that intrinsic excitability is reduced following large depolarizing bursts. This refractory period limits very slow breathing frequencies. Inhibition integrated within required...
Abstract Objective A novel COVID‐19 therapeutic, nirmatrelvir/ritonavir (Paxlovid), is commonly associated with reports of dysgeusia. The Food and Drug Administration Adverse Event Reporting System (FAERS) database was used to determine the real‐world reporting Paxlovid‐associated dysgeusia (PAD), identify factors, describe relative rates for Paxlovid compared other therapeutics (OCT), ritonavir alone, protease inhibitors (OPI). Study Design Observational retrospective. Setting Tertiary...
Background: Exposure to ambient air pollution particulate matter (PM) is associated with increased risk of dementia and accelerated cognitive loss. Vascular contributions impairment are well recognized. Chronic cerebral hypoperfusion (CCH) promotes neuroinflammation blood–brain barrier weakening, which may augment neurotoxic effects PM. Objectives: This study examined interactions nanoscale (nPM; fine aerodynamic diameter ≤200 nm) CCH secondary bilateral carotid artery stenosis (BCAS) in a...
Cerebrovascular pathologies are commonly associated with dementia. Because air pollution increases arterial disease in humans and rodent models, we hypothesized that would also contribute to brain vascular dysfunction. We examined the effects of exposing mice nanoparticulate matter (nPM; aerodynamic diameter ≤200 nm) from urban traffic interactions cerebral hypoperfusion. C57BL/6 were exposed filtered or nPM without bilateral carotid artery stenosis (BCAS) analyzed by multiparametric MRI...
Vocal fold atrophy (VFA) is associated with aging and Parkinson's disease (PD). Clinical diagnosis of VFA depends on several visual-perceptual laryngostroboscopy findings that are inherently subjective. The purpose this study was to use quantitative measurements to; (1) examine the relationships between dysphonia severity (2) evaluate differences in patients age-related versus PD.Thirty-six >60 years age were included retrospective cohort study. Demographic information, medical history,...
Direction selectivity is a robust computation across broad stimulus space that mediated by activity of both rod and cone photoreceptors through the ON OFF pathways. However, rods, S-cones, M-cones activate circuits via distinct pathways relative contribution each to direction unknown. Using variety stimulation paradigms, pharmacological agents, knockout mice lack transduction, we found inputs from pathway were critical for strong direction-selective (DS) tuning in pathway. For UV light...
Exposure to ambient air pollution has been associated with white matter damage and neurocognitive decline. However, the mechanisms of this injury are not well understood remain largely uncharacterized in experimental models. Prior studies have shown that exposure particulate (PM), a sub-fraction pollution, results neuroinflammation, specifically upregulation inflammatory microglia. This study examines axonal injury, characterizes microglial reactivity corpus callosum mice exposed 10 weeks...
Age-related changes to the larynx are associated with dysphonia and contribute reduced quality of life. This study utilizes recurrent laryngeal motor nerve conduction studies (rlMNCS) determine if neurophysiologic occur in aging using an rat model.
Objective Age‐related vocal atrophy (ARVA) is associated with fold bowing, persistent glottal gap during phonation, and dysphonia. Bilateral medialization thyroplasty sometimes performed in patients ARVA to improve closure voice. We set out quantify stroboscopic changes closure, abduction angle following bilateral determine how these affect voice quality among ARVA. Methods Fifteen individuals who underwent were included this study. Two independent investigators calculated bowing index (BI),...
Disease or injury can cause neuromuscular changes to the larynx that affect voice, breathing, and swallowing. Motor nerve conduction studies have had limited use in study of laryngeal neurophysiology, despite their importance other anatomic sites. The aim this was explore feasibility performing recurrent motor (rlMNCS) a rat model.rlMNCS were performed 15 rats under anesthesia. A bipolar stimulating electrode placed on (RLN) 5 mm below cricoid cartilage. Via direct laryngoscopy, recording...
Objective The superior laryngeal nerve (SLN) is fundamental in sensation, cough reflex, and pitch control. SLN injury has substantial consequences including altered aspiration, dysphonia. To date, vivo measurement of the remains elusive. purpose this study was to assess feasibility recording motor sensory evoked potentials a rat model. Methods Twenty‐two hemi‐laryngeal preparations ( n = 11) were obtained from 4‐month‐old Sprague–Dawley rats included study. Compound action (CMAPs) unit...
Age-related vocal atrophy (ARVA) causes fold bowing, impacting communication and quality of life. The assessment bowing is largely subjective. Glottal Image Capture (GlottIC) a new mobile application that helps quantify bowing. We aim through this study to assess its reliability, compare it manual calculation method, differences between visual-perceptual severity ratings.
The preBötzinger Complex (preBötC), located in the medulla, generates inspiratory phase of breathing. A specific lineage excitatory neurons, derived from Dbx1 expressing precursors, seems to underlie rhythmogenesis preBötC. In vitro and modelling studies suggest synaptic dynamics (e.g. presynaptic facilitation depression) among neurons result neuronal synchrony, population burst termination, a refractory period for neural synchrony following preBötC burst. However, are estimated comprise...
Abstract Introduction: Since the 2017 W.H.O. classification of pituitary adenomas redefined null cell (NCAs) as negative for all adenohypophyseal hormones and transcription factors (TFs) SF-1, PIT-1, T-PIT, limited data exist characterizing these tumors1. We characterize NCAs in comparison to hormone (HNAs), which demonstrate immunostaining context positive TF immunoreactivity. Methods: Retrospective review 22 patients with HNAs between 2011-2019. Samples were stained PIT-1 SF-1. Negative...
Introduction: Exposure to ambient air pollution, specifically the nano-scale subfraction (nPM; particles <200nm diameter), is associated with white matter damage and neurocognitive decline in both experimental human studies. The histopathology cognitive correlates are similar those observed vascular dementia small vessel ischemic disease. nPM-associated involves microglial activation. However, phenotype time course of remain uncharacterized. This study examines myelin injury microglia...