A5063553395- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Head and Neck Surgical Oncology
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- IgG4-Related and Inflammatory Diseases
- Central Venous Catheters and Hemodialysis
- Neuroendocrine Tumor Research Advances
- Otitis Media and Relapsing Polychondritis
- Vascular anomalies and interventions
- Sinusitis and nasal conditions
- Adrenal and Paraganglionic Tumors
- Hospital Admissions and Outcomes
- PARP inhibition in cancer therapy
- Ocular Oncology and Treatments
- Pituitary Gland Disorders and Treatments
- Integrated Circuits and Semiconductor Failure Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Sarcoidosis and Beryllium Toxicity Research
- Vascular Procedures and Complications
St. Jude Children's Research Hospital
2025
Washington University in St. Louis
2021-2024
Mallinckrodt (United States)
2021-2023
Neurological Surgery
2023
ABSTRACT Although primary tumor control rates after surgery and/or radiation therapy (RT) are generally high in patients with Ewing sarcoma (EWS), those unresectable tumors have failure approaching 30% and experience poorer outcomes. Additionally, although metastatic site irradiation is associated improved survival, dose, volume effects influence the long‐term toxicity risk. Consequently, it important to identify novel systemic agents enhance therapeutic ratio of RT. Given reported DNA...
The Pipeline embolization device (PED) is widely used for the treatment of intracranial aneurysms, including in off-label applications. In this work, authors compared real-world efficacy and safety PED use on-label aneurysm treatments.
Flow diversion of intracranial aneurysms with the Pipeline Embolization Device (PED) is commonly performed, but value long-term angiographic follow-up has not been rigorously evaluated. Here we examine prevalence actionable findings aneurysm recurrence and development in-stent stenosis in a cohort patients that underwent at multiple time points.Angiographic data from eligible were retrospectively assessed for occlusion, stenosis, regrowth or recurrence. Patients included this study if they...
Pilocytic astrocytomas (PAs) have a generally favorable prognosis; however, progression or recurrence after resection is possible. The prognostic value of histopathological qualifiers (defined below) BRAF alterations not well understood. aim this study was to identify the genetic and features pediatric PAs.Patients treated for WHO grade I PA at single institution were analyzed outcomes. "Histopathological qualifier" refers designations such as "WHO with increased proliferative index."...
Flow diversion of intracranial aneurysms with the Pipeline Embolization Device (PED) is frequently performed, but outcomes retreatment for that failed to occlude after prior treatment PED have not been well studied. Here, we report safety and efficacy initial failure occlude.Clinical angiographic data from eligible patients were retrospectively assessed demographics, aneurysm occlusion status, clinical outcomes. Patients included in this study if they underwent treat an had previously...
Despite the adoption of same-day outpatient surgical procedures in some specialties, it remains common practice to admit patients for monitoring after elective endovascular treatment brain aneurysms monitor complications. The necessity such has not been fully characterized. Here, authors reviewed utilization imaging during posttreatment hospitalization, a surrogate measure workup suspected complications requiring hospital resources, infer value inpatient aneurysm treatment.
Summary Tumor location has been proposed as a prognostic factor for pilocytic astrocytoma (PA), but since resection status varies by CNS location, these two variables are difficult to separate on multivariate analysis. To eliminate confounding variable, we analyzed the outcomes of children with subtotally resected PA brain location. We found that individuals in supratentorial midline region had an increased likelihood multiple progression events. These also exhibited more neurologic deficits...
Introduction A low subfrontal dural opening technique that limits brain manipulation was assessed in patients who underwent frontotemporal approaches for anterior fossa lesions. Methods retrospective review performed cases using a including characterization of demographics, lesion size and location, neurological ophthalmological assessments, clinical course, imaging findings. Results 23 (17F, 6M), median age 53 years (range 23-81) with follow-up duration 21.9 months 6.2-67.1). Lesions...
<h3>Introduction/Purpose</h3> Flow diversion of intracranial aneurysms with the Pipeline embolization device is commonly performed, but value long-term angiographic follow-up has not been rigorously evaluated. Here, we examine prevalence actionable findings aneurysm recurrence and development in-stent stenosis in a cohort patients that underwent at multiple timepoints. <h3>Materials Methods</h3> Angiographic data from eligible was retrospectively assessed for occlusion, stenosis, regrowth or...
Intracranial aneurysms of the middle cerebral artery can be treated using several open surgical and endovascular approaches. Given growing evidence clinical equipoise between these various treatment strategies, there is a need to assess costs associated with each.Cost aneurysm was divided into two categories for comparison. "Initial cost" comprised total in-hospital expenses initial "total all relating readmission due treatment-related complications, prescribed catheter angiograms monitoring...
Abstract Pilocytic astrocytomas are the most common solid tumor of childhood and can arise anywhere in central nervous system, including posterior fossa (pf-PA), supratentorial midline (sm-PA; optic pathway, hypothalamus, thalamus), brainstem (bs-PA). Location (sm, bs) has been previously proposed as a prognostic factor for PA, but is difficult to separate from resection status on multivariate analysis. To overcome this limitation, we assembled large cohort children (n = 251) with...
<h3>Introduction</h3> Elective treatment of intracranial aneurysms comprises a large share neurointerventional practice. With increasing demand for endovascular aneurysm treatment, there is need to assess factors such as operator fatigue and time-related effects that may influence the development clinical complications, particularly in elective setting. Here, we review cohort treatments quantify weekday on post-treatment neuroimaging occurrence complications. <h3>Methods</h3> Clinical...