A5057246360- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Infant Development and Preterm Care
- Older Adults Driving Studies
- Neonatal Respiratory Health Research
- Traumatic Brain Injury and Neurovascular Disturbances
- MRI in cancer diagnosis
- Spinal Fractures and Fixation Techniques
- Urban Transport and Accessibility
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Neuroscience of respiration and sleep
- Multiple Sclerosis Research Studies
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Obesity, Physical Activity, Diet
- Glioma Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Pelvic and Acetabular Injuries
- Seedling growth and survival studies
- Cancer, Lipids, and Metabolism
- Diabetes Treatment and Management
- Organ Transplantation Techniques and Outcomes
- Nonmelanoma Skin Cancer Studies
- Pancreatic function and diabetes
Washington University in St. Louis
2015-2024
St. Louis Children's Hospital
2014-2023
Saint Louis University
2022
The University of Texas Southwestern Medical Center
2022
Smith Family
2020
Cancer Research And Biostatistics
2019
RELX Group (Netherlands)
2013-2017
Neurological Surgery
2016
University of Missouri–St. Louis
2015
Missouri Department of Conservation
2004-2008
Although many perinatal factors have been linked to adverse neurodevelopmental outcomes in very premature infants, much of the variation outcome remains unexplained. The impact on brain development 1 potential factor, exposure stressors neonatal intensive care unit, has not yet studied a systematic, prospective manner.In this cohort study infants born at <30 weeks gestation, nurses were trained recording procedures and cares. These recordings used derive Neonatal Infant Stressor Scale...
The impact of treating electrographic seizures in hypoxic ischemic encephalopathy (HIE) is unknown.Neonates ≥36 weeks with moderate or severe HIE were randomly assigned to either treatment alone (ESG) clinical (CSG). Conventional EEG video was monitored both groups for up 96 hours. Cumulative seizure burden (SB) calculated seconds and converted log units analysis. MRI scans scored severity brain injury. Infants underwent neurodevelopmental evaluation at 18 24 months. Statistical analyses...
Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic treatments. Thymic stromal lymphopoietin (TSLP) an epithelium-derived cytokine that induces robust antitumor immunity in barrier-defective skin. Here, we investigated calcipotriol, topical TSLP inducer, combination with 5-fluorouracil (5-FU) as immunotherapy for keratosis.The mechanism calcipotriol action against skin...
Topical calcipotriol plus 5-fluorouracil (5-FU) combination is an effective immunotherapy against actinic keratosis (AK), which a precursor to squamous cell carcinoma (SCC). However, the long-term effectiveness of 5-FU treatment for SCC prevention unknown.We performed blinded prospective cohort study on participants randomized double-blind clinical trial in 4-day course topical was compared Vaseline (control) AK treatment. and basal (BCC) incidences were assessed at 1, 2, 3 years after...
Importance Intensive behavioral interventions for childhood overweight and obesity are recommended by national guidelines, but currently offered primarily in specialty clinics. Evidence is lacking on their effectiveness pediatric primary care settings. Objective To evaluate the effects of family-based treatment or implemented children parents siblings. Design, Setting, Participants This randomized clinical trial 4 US settings enrolled 452 aged 6 to 12 years with obesity, parents, 106 were...
Objectives To develop a cognitive and functional screening battery for the on-road performance of older drivers with dementia. Design Prospective observational study. Setting On-road driving evaluation clinic at an academic rehabilitation center. Participants Ninety-nine people dementia (63% male, mean age 74.2 ± 9), referred by community physicians to occupational therapy clinic. Measurements The outcome variable was pass or fail on modified Washington University Road Test. Predictor...
Elucidation of optimal dosing and treatment content is critical for health care providers, payers, policy makers, as well mechanisms change to inform intervention delivery training initiatives childhood obesity.
Chronic low back pain (LBP) is the most prevalent chronic in adults, and there no optimal nonpharmacologic management. Exercise recommended, but specific exercise-based treatment has been found to be effective.
Glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-stimulated insulin secretion (GSIS). This response is blunted in type 2 diabetes (T2DM). Xenin-25 a 25-amino acid neurotensin-related peptide that amplifies GIP-mediated GSIS hyperglycemic mice. study determines if xenin-25 humans with normal glucose tolerance (NGT), impaired (IGT), or T2DM. Each fasting subject received graded infusions to progressively raise plasma concentrations, along vehicle alone, GIP, xenin-25, GIP...
Objectives To differentiate driving errors in persons with dementia who fail a performance‐ based road test from pass. Design Cross‐sectional. Setting Community. Participants Active drivers diagnosed (n = 60) and older adult controls 32). Measurement All participants completed standardized clinical on‐road assessment. The outcome variable was the number types of according to Record Driving Errors ( RODE ), tool record errors. Results Sixty‐two percent 37) individuals 3% 1) failed test. Based...
BACKGROUND Massive transfusion protocols (MTPs) to address hemorrhage are understudied in children. The objective was determine the effect of MTP implementation on outcomes injured STUDY DESIGN AND METHODS This a retrospective comparison children before and after for less than 18 years old who presented 2005 2014 received red blood cells (RBCs) within 24 hours arrival. Children were divided into groups based pre‐/post‐MTP subgrouped receipt massive (≥40 mL/kg RBCs or ≥80 total products at hr...
Magnetic resonance imaging markers have been widely used to detect and quantify white matter pathologies in multiple sclerosis. We recently developed a diffusion basis spectrum (DBSI) distinguish co-existing axonal injury, demyelination, inflammation sclerosis patients animal models. It could serve as longitudinal marker for loss, primary cause of permanent neurological impairments disease progression. Eight 10-week-old female C57BL/6 mice underwent optic nerve DBSI, followed by week-long...
Adult prediction rules for cervical spine injury (CSI) exist; however, pediatric do not. Our objectives were to determine test accuracies of retrospectively identified CSI risk factors in a prospective cohort and compare them de novo model.We conducted 4-center, observational study children 0 17 years old who experienced blunt trauma underwent emergency medical services scene response, evaluation, and/or imaging. Emergency department providers recorded factors. CSIs classified by reviewing...
Patient-centered care requires pediatricians to address parents’ health concerns, but their willingness solicit parental concerns may be limited by uncertainty about which topics will raised. The authors conducted surveys of parents identify current health-related issues concern. Methods Participants rated 30 items as problems for children in community (large, medium, small, or no problem) and volunteered own children. Results A total 1119 completed the survey. Allergies (69%), lack exercise...