A5015642670- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Cutaneous Melanoma Detection and Management
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Skin Protection and Aging
- Health Systems, Economic Evaluations, Quality of Life
- melanin and skin pigmentation
- Urticaria and Related Conditions
- Nonmelanoma Skin Cancer Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hidradenitis Suppurativa and Treatments
- Dermatologic Treatments and Research
- Acne and Rosacea Treatments and Effects
- Colorectal and Anal Carcinomas
- Oral Health Pathology and Treatment
- Nail Diseases and Treatments
- Diagnosis and Treatment of Venous Diseases
- Asthma and respiratory diseases
- Spondyloarthritis Studies and Treatments
- Dermatological diseases and infestations
- COVID-19 and healthcare impacts
- Oral and Maxillofacial Pathology
- COVID-19 Clinical Research Studies
Centro Studi GISED
2016-2025
University Hospital of Bern
2016-2025
University of Bern
2016-2025
Italfarmaco (Italy)
2020-2025
Hôpital de l'enfance
2023
Ospedale Papa Giovanni XXIII
2015-2022
Post Graduate Institute of Medical Education and Research
2021
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2009-2020
Guglielmo da Saliceto Hospital
2020
University of Turin
2020
Population-based studies about contact allergy are scarce.To obtain reliable estimates of the prevalence in general population Europe.A cross-sectional study a random sample from population, aged 18-74 years, five different European countries (Sweden, Netherlands, Germany, Italy and Portugal). In total, 12 377 subjects were interviewed (n = 3119) patch tested to TRUE Test panels 1-3 Fragrance Mix (FM) II, hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) sesquiterpene lactone mix. A...
Increased body mass index and weight gain are risk factors for psoriasis, the prevalence of obesity in patients with psoriasis is higher than general population. Limited data exist regarding role diet psoriasis. To assess impact a dietary intervention combined physical exercise loss on improving overweight or obese patients. This study included 303 moderate‐to‐severe chronic plaque who did not achieve clearance after 4 weeks continuous systemic treatment. They were randomized to receive...
There is a lack of prevalence data on skin diseases in the general adult population; most studies have been carried out small, national or consecutive clinical samples.To determine common disease European population and to assess differences characteristics treatment between countries.A random sample consisting 12 377 participants aged 18-74 years was drawn from five countries (Germany, Italy, Netherlands, Portugal Sweden). This cross-sectional study all were interviewed using standardized...
Abstract Background Dupilumab is used for the treatment of atopic dermatitis (AD). Approximately one third AD patients develop a dupilumab‐associated ocular surface disease (DAOSD), which pathomechanism poorly understood. This study aimed at investigating inflammatory markers in tear fluids on dupilumab therapy. Methods Tear were collected from with DAOSD (ADwDAOSD), without (ADw/oDAOSD), and non‐AD before during therapy, analyzed using specialized proteomic approach quantifying markers. The...
Abstract Objective To evaluate variations in laboratory parameters and diagnoses of selected clinical conditions up to 16 weeks after starting a new systemic psoriasis treatment for Psocare Registry enrollees. Design Prospective cohort study. Setting Italian public referral centres treatment. Patients First‐time recipients ( n = 10,539) continuous at least weeks. Main outcome measure Mean (weeks 8 16) proportions patients reaching clinically meaningful increase serum levels (week total...
Purpose Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe cutaneous adverse drug reactions. We assessed incidence, exposure mortality, analysing data obtained from the Lombardy Registry of Severe Cutaneous Reactions (REACT). Methods Data were collected hospitals in Italian region (9 502 272 people). A trained monitor was sent to reporting hospital collect on clinical features. The algorithm for causality applied assess causality. Defined Daily Dose (DDD)...
Contact allergy to fragrances is assessed mostly in clinical populations of patients. Studies the general population are scarce and vary their methodology across countries.To determine prevalence fragrance contact European assess relevance positive patch test reactions different fragrances.In five countries (Germany, Italy, Netherlands, Portugal Sweden) a random sample from aged 18-74 years was drawn. In total, 12 377 subjects were interviewed this cross-sectional study (n = 3119) tested...
Background Studies on sensitization to metals in the general population are scarce. Objectives To determine prevalence of population, and factors associated with nickel sensitization. Methods In 5 European countries (The Netherlands, Germany, Italy, Portugal Sweden), a random sample ( N = 3119) from (aged 18‐74 years) was patch tested interviewed by use questionnaire exposure metals, piercing, jewellery. Results Overall, age‐standardized prevalences nickel, cobalt chromium were,...
Abstract Background Psoriasis (Ps) is a chronic systemic autoimmune disease associated with pruritus in 64–98% of patients. However, few modestly sized studies assess factors psoriatic pruritus. Objective To investigate Ps intensity. Methods patients 18 years or older seen one 155 centres Italy between September 2005 and 2009 were identified from the Italian PsoCare registry. Patients without cutaneous psoriasis those missed information on excluded. Results We 10 802 patients, mean age 48.8...
Journal Article Randomized controlled trial comparing the effectiveness of 308‐nm excimer laser alone or in combination with topical hydrocortisone 17‐butyrate cream treatment vitiligo face and neck Get access F. Sassi, Sassi Centro Studi GISED Search for other works by this author on: Oxford Academic Google Scholar S. Cazzaniga, Cazzaniga GISEDDepartment Mathematics, University Milan, Italy G. Tessari, Tessari Department Dermatology, Verona, L. Chatenoud, Chatenoud Unit Analytic...
In spite of progress in understanding the mechanisms underlying hidradenitis suppurativa (HS) as an inflammatory skin disease, there is still a demand for overview on immunopathogenesis HS.To demonstrate importance type 1/type 17 immune response lesional HS by drawing semantic connectivity map.Single-center case series 24 patients with HS. Association T helper 1/T (TH1/TH17) phenotype was assessed using map analysis.Association TH1/TH17 phenotype.The analysis performed biopsy samples from...
Abstract Background Different lifestyle and dietetic factors have been linked with the onset severity of acne. Objective To assess complex interconnection between variables Methods This was a reanalysis data from case–control study by using semantic connectivity map approach. 563 subjects, aged 10–24 years, involved in acne March 2009 February 2010, were considered this study. The analysis evaluated link moderate to severe anthropometric variables, family history factors. Analyses conducted...
Abstract Background Limited data are available on risk factors associated with lichen sclerosus and no gender differences in genital ( GLS ). Objective This multicentre study aimed at identifying potential for , through collection from a large, mixed‐sex sample of patients comparing gender‐related relation to the general population. Methods was cross‐sectional 729 subjects (53.8% females, 46.2% males) affected consecutively observed within network 15 Italian dermatology units. The following...
Efficacy and safety of Givinostat have been assessed in the Epidys phase 3 study (NCT02851797). DSC/14/2357/51 (NCT03373968) is an ongoing open label, long-term 194 DMD subjects enrolled givinostat studies. 142 from were matched to ImagingDMD (NCT01484678) CINRG (NCT00468832) natural history studies (control group) using propensity score matching based on baseline results functional tests type steroid.
Efficacy and safety of Givinostat, an oral histone deacetylase inhibitor for the treatment Duchenne Muscular Dystrophy (DMD) have been assessed in Epidys phase 3 study (NCT02851797). Patients enrolled Givinostat studies transitioned to DSC/14/2357/51 (NCT03373968), ongoing open label, long-term DMD subjects treated until marketing approval. In 51, at data cut 31st December 2023, 207 patients were 186 are followed, with a mean duration exposure 3.18 years maximum 6.1 years.