A5086520752- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- Tendon Structure and Treatment
- Sports injuries and prevention
- Tissue Engineering and Regenerative Medicine
- Sports Performance and Training
- Metabolomics and Mass Spectrometry Studies
- Electrospun Nanofibers in Biomedical Applications
- Pharmacological Effects and Assays
- Pluripotent Stem Cells Research
- Metabolism and Genetic Disorders
- Physical Activity and Health
- Cardiovascular and exercise physiology
- Biochemical Analysis and Sensing Techniques
- Congenital heart defects research
- Diet and metabolism studies
- Orthopedic Surgery and Rehabilitation
- Muscle activation and electromyography studies
- Neurogenetic and Muscular Disorders Research
- Extracellular vesicles in disease
- Genetics, Aging, and Longevity in Model Organisms
- Adrenal and Paraganglionic Tumors
- Mesenchymal stem cell research
Frederiksberg Hospital
2023-2025
Copenhagen University Hospital
2021-2025
University of Copenhagen
2021-2025
National Institute of Advanced Industrial Science and Technology
2025
Doshisha University
2023-2024
Japan Society for the Promotion of Science
2017-2022
Kumamoto University
2020-2022
Nagasaki University
2017-2021
Ritsumeikan University
2014-2018
Irisin is mainly released from skeletal muscle (myocytes) and promotes thermogenesis by browning of the white adipose tissue. Although exercise has been shown to increase irisin concentration in blood myocytes via up-regulation peroxisome proliferator receptor γ coactivator-1α (PGC-1α) expression, influence intensity on secretion remains unclear. Therefore, we determined circulating responses following a single bout running at different intensities. Six sedentary males underwent treadmill...
Abstract Satellite cells, the muscle tissue stem express three Notch receptors (Notch1–3). The function of Notch1 and Notch2 in satellite cells has to date not been fully evaluated. We investigated role myogenic progression adult skeletal using tamoxifen-inducible cell-specific conditional knockout mice for (N1-scKO), (N2-scKO), Notch1/Notch2 (scDKO). In quiescent state, number was slightly reduced N2-scKO, but significantly N1-scKO, almost completely depleted scDKO mice. N1-scKO N2-scKO...
Muscle satellite cells are normally quiescent but rapidly activated following muscle damage. Here, we investigated whether damaged myofibers influence the activation of cells. Our findings revealed that directly by damaged-myofiber-derived factors (DMDFs). DMDFs induced to enter cell cycle; however, stayed at G1 phase and did not undergo S phase, these were reversible quiescent-like state. Proteome analysis identified metabolic enzymes, including GAPDH, as DMDFs, whose recombinant proteins...
Abstract Tendon injuries and disorders associated with mechanical tendon overuse are common musculoskeletal problems. Even though tendons play a central role in human movement, the intrinsic healing process of is very slow. So far, it known that cell activity supported by several interstitial cells within tendon. However, interplay between adjacent muscle for regeneration development processes has not been fully investigated. Here, we tested whether factors released from derived myogenic...
Adult muscles and their associated stem cells retain functional positional memory based on developmental origin.
The present study examined the effects of wearing a lower-body compression garment (CG) after endurance exercise on recovery physiological function. 18 males were divided into 2 experiments, downhill running (n=10, DHR) experiments and level (n=8, LR) experiments. Subjects performed 30 min DHR (gradient: − 10%) or LR 0%) at 70% ˙VO<sub>2</sub>max with either CG (CG trial) normal (CON for 24 h running. Changes in jump performance (counter movement jump; CMJ, rebound RJ, drop DJ), subjective...
Acute exercise in the heat has been shown to reduce appetite. However, influence of cold on appetite regulation remains unclear. The aim this study was compare exercise-induced under three different environmental temperatures.Eleven male participants completed experimental trials following separate days: (36 °C), at neutral temperature (24 and (12 °C). consisted pedaling exercises for 30 min 65% maximal oxygen uptake (VO2max). Blood samples were collected repeatedly determine plasma ghrelin,...
Skeletal muscle possesses adaptability to mechanical loading and regenerative potential following injury due stem cell activity. So far, it is known that activity supported by the roles of several interstitial cells within skeletal in response damage. The adjacent tendon also exposed repetitive plasticity like muscle. However, interplay between tissue has not been fully investigated. In this study, we tested whether factors released three-dimensional engineered human constructs uniaxial...
[Purpose] To determine the effects of exercise-induced muscle damage, we examined irisin responses during level running (LR), with less and downhill (DHR), greater damage under equivalent exercise duration oxygen consumption (⩒O2) conditions. [Methods] Fifteen healthy men (age: 21.6 ± 2.0 y, height: 170 1.3 cm, weight: 64.8 2.7 kg) were randomly assigned to either LR group (n = 8) or DHR 7). Subjects in performed treadmill at 70% maximum uptake (⩒O2max) for 30 min on a 0% gradient. In...
Skeletal muscles are distributed throughout the body, presenting a variety of sizes, shapes and functions. Here, we examined whether muscle regeneration atrophy occurred homogeneously body in mouse models.Acute was induced by single intramuscular injection cardiotoxin adult mice. Chronic assessed mdx Muscle different evaluated cancer cachexia, ageing castration models.We found that, cardiotoxin-injected acute injury model, head slowly regenerated, while limb exhibited rapid even overgrowth....
Skeletal muscle possesses remarkable adaptability to mechanical loading and regenerative potential following injury primarily due satellite cell activity. Although the roles of several types interstitial cells in skeletal have been documented, signaling interplay between adjacent tendon tissue has not elucidated. Here, we tested whether human derived (tenocytes) could induce myogenic (myoblasts) proliferation differentiation vitro using co-culture experiments that allowed us investigate...
Muscle stem cells (satellite cells), located on the surface of myofibers, are rapidly activated from a quiescent state following skeletal muscle injury. Although satellite cell activation is an initial step in regeneration, stimulation by injury remains to be elucidated. We recently established vitro mechanical damage model analyze and associated with myofibers isolated extensor digitorum longus mice. Here, we described protocol for co-culture intact healthy damaged floating condition. This...
Irisin, which leads to augmentation of energy expenditure via browning white adipose tissue, is released from skeletal muscle as PGC-1α dependent myokine. Although previous studies have verified transient elevation blood irisin concentrations in response sprint training, the influence different frequency within a day on has not been fully understood. Additionally, lower glycogen levels are thought be stimulus for increasing exercise-induced (up-stream factor irisin) expression. Therefore, we...
Irisin leads to increasing in energy expenditure during resting period via browning of white adipose tissue as PGC-1α dependent myokine. We have previously suggested that high-intensity exercise causes greater irisin response than low-intensity (Tsuchiya et al. 2014, Tohoku J. Exp. Med; Tsuchiya 2015, Metabolism). Moreover, these exercises induced increases with concomitant elevation muscle damage markers. However, information about influence exercise-induced on has not been reported....