A5101612464- Advanced biosensing and bioanalysis techniques
- Tactile and Sensory Interactions
- Photoacoustic and Ultrasonic Imaging
- Photodynamic Therapy Research Studies
- Interactive and Immersive Displays
- Optical Imaging and Spectroscopy Techniques
- Ergonomics and Musculoskeletal Disorders
- Photonic and Optical Devices
- Advanced Fluorescence Microscopy Techniques
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- DNA and Biological Computing
- Optical Coherence Tomography Applications
- DNA and Nucleic Acid Chemistry
- Advanced Biosensing Techniques and Applications
- Gaze Tracking and Assistive Technology
- Near-Field Optical Microscopy
- Dermatologic Treatments and Research
- Skin Protection and Aging
- Ocular and Laser Science Research
- Analytical Chemistry and Sensors
- Laser Applications in Dentistry and Medicine
- Neural Networks and Reservoir Computing
- Orbital Angular Momentum in Optics
- Molecular Junctions and Nanostructures
Osaka University
2016-2025
Waseda University
2012-2024
Shizuoka University
2024
National Center for Global Health and Medicine
2023-2024
Asahi General Hospital
2023
National Institute of Special Education
2015-2022
Osaka Metropolitan University
2022
Hitachi (Japan)
2019-2022
Center For Children With Special Needs
2019-2021
Japan Society for the Promotion of Science
2010-2021
Significance: In laser therapy and diagnosis of skin diseases, the irradiated light distribution, which is determined by absorption coefficient μa reduced scattering μs′ epidermis, dermis, subcutaneous fat, affects treatment outcome accuracy. Although values for have been reported, detailed analysis Asian tissues still lacking. Aim: We present measurements in 400- to 1100-nm wavelength range evaluating optical penetration depth energy deposition. Approach: The with human samples are...
<title>Abstract</title> <bold>Purpose: </bold>Short-pulsed lasers provide safe and efficacious treatment of pigmented lesions by setting irradiation parameters based on immediate whitening resulting from vacuolization. However, visual observation this phenomenon as an endpoint is subjective makes it difficult to assess the depth which light response induced inside skin. To quantitatively understand dependence parameters, study analyzes spatial distribution light-melanosome interaction...
The optical characteristics of a human lung, such as the light distribution in tissue, are crucial for evaluating delivery photodynamic therapy (PDT) peripheral lung cancer. is analyzed with absorption ( μa ) and reduced scattering μs' coefficients measured ex vivo normal, carbon-deposited, tumor tissues. spectra were using double-integrating-sphere system inverse Monte Carlo technique. values used to perform analysis transport simulation. varied between tissue types owing influence carbon...
This paper presents a method of information processing using biomolecular input signals and fluorescence resonance energy transfer (FRET) signaling constructed on DNA scaffold. Logic operations are achieved by encoding molecular inputs into an arrangement dyes simple reactions evaluating logic expression local photonic that is much faster than reactions. Experimental results verify the operation complete set Boolean functions (AND, OR, NOT) combinational FRET-signal cascade.
A quantum dot network, which consists of coupled structures randomly dispersed dots, has been studied as a nano-scale optical reservoir for effective machine learning processing. In this study, we defined spatio-temporal fluorescence network the output, is due to characteristic dynamics excited energy in induced by laser pulse irradiation. order verify whether can improve processing efficiency advanced applications, performed experimental computing using numerical model. Several parameters...
Background and Objectives In this study, the threshold fluences for disrupting melanosomes pigmented skin lesion treatment were determined using a 755‐nm picosecond laser clinical use. Based on melanosome disruption thresholds, incident corresponding to target depths evaluated in silico different spot sizes. Study Design/Materials Methods Melanosome samples isolated from porcine eyes as alternative human cutaneous melanosomes. The exposed pulses measure mean particle sizes by dynamic light...
Abstract Background and Objectives A threshold fluence for melanosome disruption has the potential to provide a robust numerical indicator establishing clinical endpoints pigmented lesion treatment using picosecond laser. Although thresholds 755‐nm laser were previously reported, wavelength dependence not been investigated. In this study, wavelength‐dependent fluences determined. Using mathematical model based on thresholds, irradiation parameters 532‐, 730‐, 755‐, 785‐, 1064‐nm treatments...
SignificancePhotobleaching of the photosensitizer reduces fluorescence observation time and intensity emitted for tumor detection during 5-aminolevulinic acid-based photodynamic diagnosis.AimThis study aims to utilize concept photoswitching, which uses emission from excitation followed by simultaneous its photoproduct increase PDD deeply located tumors.ApproachThe photobleaching protoporphyrin IX (PpIX) formation photoproduct, photoprotoporhyrin (Ppp), caused exposure 505 nm light were...
Interstitial photodynamic therapy (iPDT) with 5-aminolevulinic acid (ALA) is a possible alternative treatment for malignant brain tumors. Further evaluation is, however, required before it can be clinically applied. Computational simulation of the photophysical process in ALA-iPDT offer quantitative tool understanding outcomes, which depend on various variables related to clinical conditions. We propose method tumors using singlet oxygen (O12) model and O12 threshold induce cell death. In...
The echo state property, which is related to the dynamics of a neural network excited by input driving signals, one well-known fundamental properties recurrent networks. During state, reveals an internal memory function that enables it remember past inputs. Due will asymptotically update its condition from initial and expected exhibit temporally nonlinear input/output. As physical network, we fabricated quantum-dot driven sequential optical-pulse inputs corresponding outputs, random...
Abstract A miniaturized endoscopic laser system with steering has great potential to expand the application of minimally invasive treatment for micro-lesions inside narrow organs. The conventional systems require separate optical paths imaging and steering, which limits their narrower Herein, we present a novel image-guided thin tip that can access uses single fiber bundle simultaneously acquire images modulate laser-irradiated area. insertion operation in space were demonstrated using an...
Photonic methodologies to access and control objects with a nano-scale resolution are important because of their attractive features including high sensitivity, remoteness, various implementation tools. We report self-contained photonically-controlled DNA tweezers implemented using photoisomerizing molecules. This composition is effective nanoscale propagating light, which enables us capture signals multiple in twinkle them over an area at time. Experimental results demonstrated that the...
This paper introduces a method for fabricating microscale DNA hydrogels using irradiation with patterned light. Optical fabrication allows the flexible and tunable formation of without changing environmental conditions. Our scheme is based on local heat generation via photothermal effect, which induced by light quenching species. We demonstrate experimentally that, depending power time, enables creation hydrogels, while shapes are controlled patterns.
Significance: The diagnostic depth of photodynamic diagnosis (PDD) for gastric cancer with protoporphyrin IX (PpIX) is limited, which leads to missing intramucosal cancers in screening and surgery. Aim: reason that the excitation light, whose wavelength determined by highest absorption peak PpIX (∼405 nm), strongly attenuated mucosal tissues. We investigated an can extend fluorescence at subsurface. Approach: By calculating depth-dependent intensity light porcine mucosa each wavelength,...
Fluorescence resonance energy transfer (FRET) is a promising method of implementing photonic circuits at nanoscale. This letter presents set–reset flip-flop that consists fluorescent molecules organized by DNA hybridization. In the proposed flip-flop, state changes according to optical input and current state, then FRET switched between on off depending its state. The experimental results demonstrate can modulate flow, repeated cycle transitions are induced.
Abstract Background and Objectives The clinical use of 532‐nm short‐pulsed lasers has provided effective treatment epidermal pigmented lesions. However, the detection significant differences in effects between picosecond nanosecond still varied among studies. For robust evaluation based on mechanism, this study presents a nonlinear absorption‐based analysis energy deposition melanosomes for laser treatment. Study Design/Materials Methods Nonlinear absorption by melanin is modeled sequential...