A5049851951- Urticaria and Related Conditions
- Mast cells and histamine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Colorectal Cancer Surgical Treatments
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Polyomavirus and related diseases
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Contact Dermatitis and Allergies
- Pancreatitis Pathology and Treatment
- Dermatology and Skin Diseases
- Wound Healing and Treatments
- Immunotherapy and Immune Responses
- melanin and skin pigmentation
- Pressure Ulcer Prevention and Management
- Dermatologic Treatments and Research
- Clinical practice guidelines implementation
- Cancer therapeutics and mechanisms
- Plant Stress Responses and Tolerance
- Antenna Design and Analysis
- Sarcoma Diagnosis and Treatment
Kyoto first Red Cross hospital
2024-2025
Hiroshima University
2020-2024
Japan Science and Technology Agency
2022
Nagaoka University
2020
Nagaoka University of Technology
2020
Advanced Genetic Systems (United States)
1987
Background Exposure to sweating stimuli triggers transient and severe dermal pain in certain individuals. This study aimed evaluate the analgesic effect of icatibant, a bradykinin B2 receptor antagonist, for induced by explored role its pathomechanism. Methods single-blind, randomized, crossover enrolled adult patients who had experienced sweating-induced pain. Participants randomly received icatibant (30 mg) or placebo on Day 1 vice versa 2. Before after drug administration, an artificial...
Urticaria is characterized by the occurrence of wheals and flares in response to vasoactive mediators, such as histamine. Various studies have suggested involvement basophils pathogenesis chronic spontaneous urticaria (CSU). However, histamine release from peripheral stimuli acting on high affinity IgE receptor (FcϵRI) impaired many patients with CSU (non/low responders). We previously demonstrated that tissue factor (TF)s expressed vascular endothelial cells a combination various stimuli,...
Abstract Immune checkpoint inhibitors (ICI) have been administrated as a standard medication in many cases of malignant melanoma (MM). They may be effective even for MM advanced stages. However, it is still challenging to reduce the burden MM, which were or became refractory ICI, especially those without BRAF gene mutation. Re‐administration ICI after other modalities treatment an option treatment, but efficacy and safety retreatment with not well established. We experienced four patients...
Chronic spontaneous urticaria (CSU) is one of the most intractable human-specific skin diseases. However, as no experimental animal model exists, mechanism underlying disease pathogenesis in vivo remains unclear, making establishment a curative treatment challenging.A novel approach combining mathematical modelling, vitro experiments and clinical data analysis was used to infer pathological state CSU patients from geometric features eruptions.Based on our hierarchical eruptions were...
Hereditary angioedema (HAE) adversely affects patients’ social and daily life significantly, the disease burden is high. We recruited study participants from a patient-participatory registry, Rare Undiagnosed Diseases Study (RUDY) Japan, to better understand broader effect of HAE on lives. Thirteen patients with who registered between January 2019 March 2021 completed an online questionnaire record details episodes quality (AE-QoL) questionnaire, in which they described degree QoL was...
Abstract Background The occurrence of postoperative complications may affect short-term outcomes and prognosis patients with various malignancies. However, the prognostic impact these in older colorectal cancer (CRC) remains unclear. Therefore, this study aimed to investigate severe on oncological (aged ≥ 80 years) non-older < CRC. Methods We retrospectively analyzed 760 stage I–III CRC who underwent curative surgery two institutions between 2013 2019. were categorized into years, 191...
Omalizumab (OMA) is highly effective for refractory chronic spontaneous urticaria (CSU), but its high cost exerts a great economic burden on patients and society. Current knowledge lacking regarding the impact of long-term administration OMA with CSU in real-world setting. We retrospectively investigated drug costs relevant to treatment during period before through 12 months after starting actual clinical practice. This study involved 32 who received at least two injections (300 mg/4 weeks)...
Meshed skin grafting is a common technique in operations to minimize surgery on the donor site area. However, area empirically determined by surgeons due lack of reliable formula calculate required cover defect. To determine minimal size for skin, expansion rates 1.5:1, 3:1, and 6:1 meshed graft actually covered them were investigated real-world operations. About 51 patients who received 57 with grafts enrolled this study. The average clinical coverage cases which or was performed 1.02,...
Cultured epidermal autografts (CEAs) are used to treat extensive burns, giant congenital melanocytic nevi, and epidermolysis bullosa, but information about the long-term clinical course after CEA transplantation is scarce. Here we report 10 years' progress of a 7-year-old Japanese girl who suffered from scald burn injury affecting 80% her total body surface area was treated with transplantation. The skin child burns CEAs appeared soft good texture, even years, recovery pigmentation scar...
Abstract Chronic spontaneous urticaria (CSU) is one of the most intractable human-specific skin diseases. However, as no experimental animal model exists, mechanism underlying disease pathogenesis in vivo remains unclear, making establishment a curative treatment challenging. Here, using novel approach combining mathematical modeling, vitro experiments and clinical data analysis, we show that pathological state CSU patients can be inferred by geometric features eruptions. Based on our...
In‑transit metastases (ITMs) in patients with malignant melanoma (MM) are associated poor prognosis and a worse disease burden compared MM without ITMs. A substantial population of ITMs show no or only responses to newly developed therapies, such as immune checkpoint inhibitors molecular‑targeted agents. It is difficult control the exudate bleeding from when these medications ineffective. In Japan, local injection interferon‑β (IFN‑β) has been licensed for years adjuvant therapy MM. However,...
Axillary web syndrome (AWS) is characterized by firm, linear, subcutaneous bands in the axilla extending to arm or hand.1 The are accompanied pain and a limited range of joint motion due tension. AWS mostly affects patients with breast cancer who have undergone axillary lymph node dissection sentinel biopsy. Although generally considered be lymphatic origin,1 exact pathogenesis remains unclear. Here we report case following an biopsy patient mycosis fungoides, which histologic examination...