A5087741774- Frailty in Older Adults
- Intensive Care Unit Cognitive Disorders
- Hip and Femur Fractures
- Cardiac, Anesthesia and Surgical Outcomes
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Immune cells in cancer
- Palliative Care and End-of-Life Issues
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Immunotherapy and Biomarkers
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Arrest and Resuscitation
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Emergency and Acute Care Studies
- Aging, Elder Care, and Social Issues
- Health, Medicine and Society
- COVID-19 and healthcare impacts
Hôpital Saint-Antoine
2018-2025
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Inserm
2016-2025
Centre d'Immunologie et des Maladies Infectieuses
2017-2024
Pitié-Salpêtrière Hospital
2009-2022
Centre National de la Recherche Scientifique
2016-2020
Hôpital Charles-Foix
2016-2019
Université Paris Cité
2017-2019
Université Sorbonne Nouvelle
2019
Objective To analyze the factors associated with response to anti–tumor necrosis factor (anti‐TNF) treatment and compare efficacy safety of infliximab (IFX) adalimumab (ADA) in patients refractory noninfectious uveitis. Methods This was a multicenter observational study 160 (39% men 61% women; median age 31 years [interquartile range 21–42]) uveitis that had been other therapies, who were treated anti‐TNF (IFX 5 mg/kg at weeks 0, 2, 6, then every 5–6 [n = 98] or ADA 40 mg 2 62]). Factors...
Abstract Background There is limited information describing the characteristics and outcomes of hospitalized older patients with confirmed coronavirus disease 2019 (COVID-19). Method We conducted a multicentric retrospective cohort study in 13 acute COVID-19 geriatric wards, from March to April 15, 2020, Paris area. All consecutive aged 70 years older, COVID-19, were enrolled. Results Of 821 included study, mean (SD) age was 86 (7) years; 58% female; 85% had ≥2 comorbidities; 29% lived an...
Rationale: Sepsis is the leading cause of death in adult ICUs. At present, sepsis diagnosis relies on nonspecific clinical features. It could transform care to have immune-cell biomarkers that predict and guide treatment. For decades, neutrophil phenotypes been studied sepsis, but a diagnostic cell subset has yet be identified. Objectives: To identify an early, specific immune signature severity does not overlap with other inflammatory distinguishes patients from those noninfectious...
Abstract Very old critically ill patients pose a growing challenge for intensive care. Critical illness and the burden of treatment in care unit (ICU) can lead to long-lasting decline functional cognitive abilities, especially very patients. Multi-complexity increased vulnerability stress these may new worsening disabilities, requiring careful assessment, prevention rehabilitation. The potential rehabilitation, which is crucial optimal outcomes, requires systematic, multi-disciplinary...
Aging is associated with functional deficits in the naive T cell compartment, which compromise generation of de novo immune responses against previously unencountered Ags. The mechanisms that underlie this phenomenon have nonetheless remained unclear. We found CD8+ cells elderly humans were prone to apoptosis and proliferated suboptimally response stimulation via TCR. These abnormalities dysregulated lipid metabolism under homeostatic conditions enhanced levels basal activation. Importantly,...
Our aim was to compare transcriptome and phenotype profiles of CD4+ T cells CD19+ B in patients with Takayasu arteritis (TAK), giant cell (GCA), healthy donors.Gene expression analyses, flow cytometry immunophenotyping, receptor (TCR) gene sequencing, functional assessments from peripheral blood arterial lesions TAK patients, GCA donors were performed.Among the most significantly dysregulated genes compared (n = 720 genes) 1,447 genes), we identified a follicular helper (Tfh) signature,...
Purpose: To compare the efficacy of infliximab and adalimumab in patients with refractory uveitis-related macular edema (ME).Methods: A retrospective study was conducted all ME treated or Pitié-Salpêtrière hospital between January 1, 2006 2016. All underwent a complete ophthalmologic examination, OCT retinal angiography at baseline, 6 (M6) 24 months (M24) after treatment initiation. Main outcome decrease central foveal thickness (CFT) on OCT.Results: Twenty-five were included: 12 13...
Highlights Innate immune activation during Covid-19 infection is associated with pernicious clinical outcome. Background Coronavirus disease 2019 (Covid-19) a worldwide threat that has already caused more than 3 000 deaths. It characterized by different patterns of evolution depending on host factors among which old-age and pre-existing comorbidities play detrimental role. Previous coronavirus epidemics, notably SARS-CoV, were increased serum neopterin levels, can be interpreted as sign...
Perioperative myocardial infarction remains a life-threatening complication in noncardiac surgery and even an isolated troponin rise (ITR) is associated with significant mortality. Our aim was to assess the prognostic value of ITR elderly patients hip fracture. In this cohort study, all admitted between 2009 2013 our dedicated geriatric postoperative unit after fracture cardiac I determination were included divided into Control, ITR, acute coronary syndrome (ACS) groups. The primary end...
To compare the association between a restrictive transfusion strategy and cardiovascular complications during hospitalization for hip fracture with liberal complications, accounting all transfusions from emergency department to postacute rehabilitation settings.Retrospective study.Perioperative geriatric care unit.All individuals aged 70 older admitted hospitalized in our perioperative unit (N=667; n=193 group, n=474 group) July 2009 April 2016.A (hemoglobin level threshold ≥8 g/dL or...
Abstract Background Few data are available on the prognosis of older patients who received corticosteroids for COVID-19. We aimed to compare in-hospital mortality geriatric hospitalized COVID-19 or not. Methods conducted a multicentric retrospective cohort study in 15 acute wards Paris area from March April 2020 and November May 2021. included all consecutive aged 70 years were with confirmed these wards. Propensity score multivariate analyses used. Results Of 1 579 (535 corticosteroids),...