A5007196719- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Cystic Fibrosis Research Advances
- Respiratory and Cough-Related Research
- Food Allergy and Anaphylaxis Research
- Tracheal and airway disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Contact Dermatitis and Allergies
- Pediatric health and respiratory diseases
- Genetic and Kidney Cyst Diseases
- Dysphagia Assessment and Management
- IL-33, ST2, and ILC Pathways
- Respiratory Support and Mechanisms
- Eosinophilic Esophagitis
- Medical Imaging and Pathology Studies
- Hedgehog Signaling Pathway Studies
- Esophageal and GI Pathology
- Nicotinic Acetylcholine Receptors Study
- Gastroesophageal reflux and treatments
- Inhalation and Respiratory Drug Delivery
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Drug-Induced Adverse Reactions
Université de Reims Champagne-Ardenne
2016-2025
Inserm
2016-2025
Centre Hospitalier Universitaire de Reims
2016-2025
Fractionnation of AgroResources and Environment
2011-2025
Hôpital Maison Blanche
2013-2024
Pathologies Pulmonaires et Plasticité Cellulaire
2017-2024
French Clinical Research Infrastructure Network
2024
Centre for Research and Information on Substance Abuse
2024
University of Southampton
2019-2022
NIHR Southampton Biomedical Research Centre
2019-2022
Dyspnea is very frequent in obese subjects. However, its assessment complex clinical practice. The modified Medical Research Council scale (mMRC scale) largely used the of dyspnea chronic respiratory diseases, but has not been validated obesity. objectives this study were to evaluate use mMRC subjects and analyze relationships with 6-minute walk test (6MWT), lung function biological parameters.Forty-five (17 M/28 F, BMI: 43 ± 9 kg/m2) included pilot study. daily living was evaluated by...
Fish is one of the most allergenic foods. While clinical cross-reactivity among different fishes a widely accepted feature fish allergy, associations with other food allergies are not well understood. This study aims at analyzing relevance between and chicken meat in patients allergy to without sensitization hen's eggs.Patients (n = 29) or only 7) were recruited. IgE-reactive proteins identified (Edman, MS analysis) quantified (ELISA). Allergens used IgE ELISA skin testing.Chicken...
Few studies have evaluated the contribution of multiple virus and bacterial infections in acute exacerbation chronic obstructive pulmonary disease. This study estimated burden viral respiratory moderate to very severe disease patients that were prospectively followed-up during a 12-month pilot study. Clinical data collected monthly sputum was at time each event. Classical culture techniques for bacteria multiplex polymerase chain reaction (PCR) microarray detection assays performed identify...
Free iron in lung can cause the generation of reactive oxygen species, an important factor chronic obstructive pulmonary disease (COPD) pathogenesis. Iron accumulation has been implicated oxidative stress other diseases, such as Alzheimer's and Parkinson's but little is known about COPD. We sought to determine if content expression transport and/or storage genes differ between controls COPD subjects, whether changes these correlate with airway obstruction. Explanted tissue was obtained from...
Airway epithelium integrity is essential to maintain its role of mechanical and functional barrier. Recurrent epithelial injuries require a complex mechanism repair restore integrity. In chronic obstructive pulmonary disease (COPD), an abnormal airway may participate in remodeling. The objective was determine if wound COPD.
Background The French RAMSES study is an observational prospective multicentre real-life cohort including severe asthmatic subjects. objective of the was to compare characteristics patients, in terms phenotype and asthma care trajectories, between those managed by tertiary referral centres (TRCs) or secondary (SCCs). Methods Patients were prospectively recruited enrolled for a 5-year follow-up. Patients’ analysed at inclusion compared TRCs SCCs. Results 52 (24 28 SCCs) included 2046...
ABSTRACT Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine activated by allergens, pathogens, and air pollutants. Recent studies suggest TSLP dysregulation in chronic inflammatory diseases. It was highlighted as a key player the context of asthma‐associated mucosal immunity. This study investigated production localization its receptors airway epithelial cells related response obstructive pulmonary disease (COPD) non‐COPD patients. transcripts proteins were detected but not abundant...
<title>Abstract</title> Background. Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition characterized by chronic respiratory symptoms due to abnormalities of the airways and/or alveoli that cause airflow obstruction. It leading death worldwide. While alterations in airway microbiota have been linked exacerbation frequency, underlying mechanisms remain unclear. Methods. This study investigated associations between composition stable COPD patients and history....
Hedgehog (HH) pathway is constantly under scrutiny in the context of organ development. Lung morphogenesis requires HH signalling which participates thereafter to pulmonary homeostasis by regulating epithelial cell quiescence and repair. Since remodelling a hallmark Chronic Obstructive Pulmonary Disease (COPD), we investigated whether main molecular actors participate airway differentiation analysed their alterations COPD patients. Sonic (Shh) secretion was assessed ELISA (AEC) air-liquid...
Abstract: Chronic cough is a common complaint and frequent cause of medical consultation. Its management can be difficult. We present here an overview the current guidelines for chronic cough. Different steps are detailed, including initial research obvious etiology alert signs that should lead to further investigation underlying condition. The diagnosis most causes: asthma, non-asthmatic eosinophilic bronchitis, gastroesophageal reflux disease upper airway syndrome considered, assessed...
The aim was to evaluate the incidence of serious infusion-related reactions (SIRRs) in RA treated by non-TNF-targeted biologics. We analysed data from three independent prospective registers, namely autoimmunity and rituximab, Orencia (abatacept) (ORA) Registry RoAcTEmra (tocilizumab), promoted French Society Rheumatology including patients with RA. SIRRs were defined an occurrence during or within 24 h infusion requiring discontinuation treatment. Characteristics extracted electronic...
Background Severe asthma is associated with multiple comorbidities, including gastro-oesophageal reflux disease (GORD), which can contribute to exacerbation frequency and poor quality of life. Since epithelial dysfunction an important feature in asthma, we hypothesised that severe the bronchial epithelium more susceptible effects acid reflux. Methods We developed vitro model GORD using differentiated cells (BECs) from normal or asthmatic donors exposed a combination pepsin, pH bile acids...
Abstract Background Obesity is a risk factor for dyspnea. However, investigations of daily living obesity-related dyspnea are limited and its mechanisms remain unclear. We conducted cross-sectional study to analyze the relationships between in living, lung function, body composition patients with obesity. Methods One-hundred thirty (103 women/27 men), candidate bariatric surgery, mean ± SD Body Mass Index (BMI) 44.8 6.8 kg/m 2 were included. Dyspnea was assessed by modified Medical Research...
Cystic Fibrosis (CF) adult patients experience daily physical symptoms and disabilities that may impact their quality of life mental health.This prospective study aimed to evaluate the relative contribution familial, occupational, social environment, besides main health factors, CF using Questionnaire-Revised (CFQ-R) in a multivariate model.Fifty were analyzed (70% men; median age 25 years; body mass index 21 kg/m²; FEV1 57%). Anxiety depression scores negatively associated with 9 12 CFQ-R...
Abstract Background Severe asthma is characterized by frequent exacerbations, altered lung function, and impaired quality of life. Tailored patient education allows for the improvement both management Our study aimed to assess needs severe in therapeutic education, according previous background phenotype. Methods Consecutive patients monitored a tertiary referral center were considered inclusion answered questionnaire detailing their topics they would like discuss. Asthma history, clinical...