A5001599981- Full-Duplex Wireless Communications
- Polyomavirus and related diseases
- Plant Virus Research Studies
- Antenna Design and Analysis
Université de Tours
2023-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023
The cell adhesion protein CD56 has been identified as a potential therapeutic target in several solid tumors and hematological malignancies. Recently, we developed CD56-directed antibody-drug conjugate (ADC), called Adcitmer demonstrated its antitumor properties preclinical models of the rare aggressive skin cancer Merkel carcinoma (MCC). present study aims to further optimize overcome limitations observed with previously evaluated CD56-targeting ADCs, which were partially related toxic...
Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high mortality rate. polyomavirus causes 80% of MCCs, encoding the viral oncogenes small T and truncated large (tLT) antigens. These proteins impair RB1-dependent G1/S checkpoint blockade subvert host epigenome to promote cancer. Whole-proteome analysis proximal interactomics identified tLT-dependent deregulation DNA damage response (DDR). Our investigation revealed, our knowledge, previously unreported interaction between tLT...