A5065141785- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders
- Sarcoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Tumors and Oncological Cases
- Skin and Cellular Biology Research
- Nail Diseases and Treatments
- Eosinophilic Disorders and Syndromes
- Soft tissue tumor case studies
- Vascular Malformations and Hemangiomas
- Ear and Head Tumors
- melanin and skin pigmentation
- Dermatological and Skeletal Disorders
- Cancer Genomics and Diagnostics
- Infectious Diseases and Mycology
- Metastasis and carcinoma case studies
- Vascular Tumors and Angiosarcomas
Icahn School of Medicine at Mount Sinai
2006-2025
Universidad Ricardo Palma
2018-2023
University of Auckland
2012-2022
Mount Sinai Medical Center
2005-2020
Medlab Central (New Zealand)
2011-2018
Auckland District Health Board
2014-2018
Universidade Federal do Piauí
2016
Waikato Hospital
2015
Auckland City Hospital
2015
In-Q-Tel
2014
Perhaps, the most intriguing cutaneous sequela of Crohn's disease (CD) is 'metastatic' CD, defined as sterile granulomatous skin lesions arising at sites discontinuous from gastrointestinal tract. Though various histopathologic patterns have been described, a lack large series has precluded comprehensive characterization and distinction pathologic differential diagnoses. The histopathology features 12 new cases metastatic CD were reviewed. Non-suppurative granulomata with slight cuff...
The differential diagnosis of atypical dermal nonepidermotropic CD8+ lymphocytic infiltrates includes a heterogeneous spectrum lymphoproliferations with overlapping histological and phenotypic features, but divergent clinical manifestations prognoses. As these neoplasms are rare, more data on their clinicopathological presentation course needed.To assess the clinical, immunophenotypic features; outcomes of; differences between lymphoproliferations.Retrospective analysis series 46 patients...
Over the years, histopathologic studies to determine nature and significance of regression in malignant melanoma have yielded different results. At least part, this most likely reflects differences definition what constitutes regression. Although partial is relatively common, complete rare. It has been said that a primary lesion associated with metastatic disease, but evidence for largely anecdotal-the literature contains only case reports small series. We found 2 cases our dermatopathology...
Spindle cell lipomas (SCL) are typically tumors of the upper back/neck (shawl region) men (80% to 90%). In general, there is a frequent tendency restrict diagnosis this specific clinical scenario and hesitancy diagnose SCL in women. We hypothesized that women have more varied presentation. A total 395 were diagnosed at our institution over last 11 years. The was confirmed by re-review. Immunohistochemical stains for CD34, desmin, estrogen receptor, p16 performed. subset, fluorescence situ...
As the New Zealand Cancer Registry does not require mandatory reporting of non-melanoma skin cancers (NMSC), basal cell carcinomas (BCC) and squamous (SCC), clinical burden these diseases is unknown.A retrospective review all patients with histopathology performed allowed us to estimate invasive BCC SCC in Auckland region 2008 (population 1.44 million).During this period, a total 21 236 NMSC were diagnosed among 13 996 patients, consisting 5611 lesions (26%) 15 525 (74%) BCC. The incidence...
Abstract Brain metastases are a major cause of melanoma-related mortality and morbidity. We undertook whole-exome sequencing 50 tumours from patients undergoing surgical resection brain presenting as the first site visceral disease spread validated our findings in an independent dataset 18 patients. had similar driver mutational landscape to cutaneous melanomas TCGA. However, KRAS was most significantly enriched gene, with 4/50 (8%) harbouring non-synonymous mutations. Hotspot mutations were...
Diabetic dermopathy presents as well-demarcated, hyperpigmented, atrophic depressions, macules or papules located on the anterior surface of lower legs diabetic patients. The histopathology remains poorly defined which may in part be due to fact that lesions are rarely biopsied. An advantage studying autopsy material is ease obtaining large biopsy specimens. To further define histopathological features this entity, we studied tissue taken from characteristic at autopsy. Inclusion criteria...
A 57‐year‐old Hispanic man with a personal and family history of bullae photosensitivity presented fungating, ulcerated squamous cell carcinoma on his left hand ( Figure 1 ). Physical examination showed conjunctival injection, ectropion, symblepharon, urethral stricture, loss teeth, short stature, nail dystrophy. There was reticulated erythema, atrophy, hyperpigmentation hypopigmentation, telangiectasia sun‐exposed skin the face, neck, hands consistent poikiloderma 2 In addition, there...
Appropriate use criteria (AUC) provide physicians guidance in test selection, and can affect health care delivery, reimbursement policy physician decision-making.The American Society of Dermatopathology, with input from the Academy Dermatology College Pathologists, sought to develop AUC dermatopathology.The RAND/UCLA appropriateness methodology, which combines evidence-based medicine, clinical experience expert judgment, was used dermatopathology.With number ratings predetermined at 3, were...
This report was designed to discuss the case of a patient taking immunosuppression after transplant who developed squamous-cell carcinoma in chronic pilonidal cyst and examine reported literature on malignant degeneration disease.We performed comprehensive review examined medical record immunosuppressive medications renal located at superior gluteal cleft.Pilonidal disease is common condition, it important know that malignancy can arise when chronic. Immunosuppression human papillomavirus...
The X-linked inhibitor of apoptosis protein (XIAP) is the most potent family eight proteins. High levels XIAP have been found in melanoma cell lines and are believed to play a role therapeutic resistance number malignancies. expression has not investigated clinically obtained tissue samples, nor studies attempted correlate with prognostic variables or clinical aggressiveness melanomas.Sixty-seven patients primary cutaneous malignant for whom follow up was available were identified from...
Abstract BACKGROUND: In a long‐term retrospective immunohistochemical study of adenoid cystic carcinoma (ACC) salivary gland, we investigated the relation p63 immunodetection to prognosis. Although it is generally agreed that solid pattern most aggressive growth, ACCs with predominantly cribriform or tubular patterns have an unpredictable clinical course, relatively favorable 5‐year survival but low 20‐year survival. METHODS: Formalin‐fixed paraffin sections from 35 cases ACC showing better...
We describe a case of Dabska tumor (DT) occurring within large congenital lymphangioma circumscriptum on the thigh 14-year-old female. Diagnostic biopsy showed numerous intravascular papillary projections lined by atypical endothelial cells anastomosing vascular channels circumscriptum. DT is regarded as intermediate malignant potential, most probably lymphatic origin. Although it has been described in pre-existing lymphangiomas, to best our knowledge this first be During follow-up 9 years,...
The dermatology service is frequently consulted to assess cutaneous eruptions after hematopoietic stem cell transplantation. We describe a case of toxoplasmosis in transplant patient where trophozoites elicited reaction pattern mimicking an interface dermatitis. At first blush, these findings may be misinterpreted as either drug or graft-versus-host disease. hope that this will prove helpful for dermatopathologists asserting the correct diagnosis toxoplasmosis-if left untreated treated...