A5046342185- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Genetic and rare skin diseases.
- Autoimmune and Inflammatory Disorders
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Fungal Infections and Studies
- Eosinophilic Disorders and Syndromes
- Tumors and Oncological Cases
- Dermatological and Skeletal Disorders
- Melanoma and MAPK Pathways
- Vascular Tumors and Angiosarcomas
- Cancer Diagnosis and Treatment
- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Polyomavirus and related diseases
- Genital Health and Disease
- Chemotherapy-related skin toxicity
- Full-Duplex Wireless Communications
- Cancer Immunotherapy and Biomarkers
- Skin Diseases and Diabetes
- Histiocytic Disorders and Treatments
- Skin and Cellular Biology Research
University of Iowa Hospitals and Clinics
2014-2024
University of Iowa
2011-2023
Veterans Health Administration
2012-2021
Iowa City VA Medical Center
2011-2017
Iowa City VA Health Care System
2016
In-Q-Tel
2013-2014
University of Missouri
2012
Methodist Hospital
2007
Des Moines University
2007
University of Colorado Anschutz Medical Campus
2006
Historically, metastatic melanoma was uniformly and rapidly lethal, treatment options were limited. In recent years, however, checkpoint inhibitors have emerged as an accepted standard for patients with advanced melanoma. clinical trials, these agents been largely well tolerated the potential to result in durable responses. Importantly though, one must recognize unique side effect profile of therapies, which can trigger or exacerbate underlying autoimmune disease. Whether this activation is...
Merkel cell carcinomas (MCCs) express the tyrosine kinase receptor KIT. However, it is not known if MCCs have activating mutations in KIT that would make them responsive to treatment with imatinib mesylate. The purpose of this article describe immunohistological staining pattern (CD117) and analyze those for areas where are found gastrointestinal stromal tumors.We evaluated immunostaining nine from patients. In addition, we extracted DNA same MCCs, performed PCR amplification C-KIT exons 9,...
Background The purpose of this study was to explore the immunohistochemical and mutational status tyrosine kinases KIT platelet derived growth receptor‐alpha ( PDGFRA ) in Merkel cell carcinoma MCC ). Specifically, we examined mutated exons gastrointestinal stromal tumors that may confer a treatment response imatinib mesylate. Methods We evaluated immunostaining 23 examples utilizing laser capture microdissection obtain pure samples tumor genomic DNA from 18 . PCR amplification sequencing 9,...
Appropriate use criteria (AUC) provide physicians guidance in test selection, and can affect health care delivery, reimbursement policy physician decision-making.The American Society of Dermatopathology, with input from the Academy Dermatology College Pathologists, sought to develop AUC dermatopathology.The RAND/UCLA appropriateness methodology, which combines evidence-based medicine, clinical experience expert judgment, was used dermatopathology.With number ratings predetermined at 3, were...
Background: It is not known if Merkel cell carcinomas (MCCs) show mutations in the platelet‐derived growth factor receptor alpha (PDGFRA) gene similar to a subset of gastrointestinal stromal tumors. The purpose this study was analyze MCCs for PDGFRA as well those exhibiting possible mutation immunohistochemical expression PDGFRA. Methods: We extracted tumor DNA from nine MCCs, performed polymerase chain reaction amplification exons 10, 12, 14 and 18, directly sequenced products mutations. In...
Nephrogenic systemic fibrosis (NSF – known previously as nephrogenic fibrosing dermopathy) is a disorder observed exclusively in patients with history of kidney disease associated renal failure. Reported histopathologic findings NSF include spindle‐shaped fibroblast‐like cells fibrosis, thickened collagen bundles surrounding spindled and epithelioid cells, increased number elastic fibers, sparse inflammatory infiltrate stromal mucin. Two populations multinucleated giant (Factor XIIIa CD68...
Early cutaneous Lyme disease, erythema migrans, manifests as a gyrate at the site of tick bite. The standard histopathologic description is that superficial and deep perivascular lymphocytic infiltrate in which plasma cells are identified periphery lesion eosinophils center. Deviation from these commonly accepted findings may lead to an erroneous diagnosis. Herein, we describe 4 cases all biopsied confirmed by serologic studies, demonstrating variety unconventional patterns. These include...
Immune checkpoint inhibitors such as ipilimumab (anticytotoxic T-lymphocyte–associated antigen), pembrolizumab, and nivolumab (anti–programmed death receptor 1) represent some of the newest most promising medications for treatment metastatic melanoma.1 As a class, immune interfere with tumoral suppression T cells, resulting in more robust response subsequent benefit melanoma, non–small-cell lung cancer, potentially other malignancies.
Cutaneous metastases from transitional cell carcinoma of the bladder are rare and most often associated with a deeply invasive primary tumor. This case report describes 69‐year‐old male previously resected superficially who presented distant cutaneous central nervous system recurrent cancer. In addition, this highlights differential diagnosis metastatic carcinomas that display CK7/CK20 positive immunophenotype including carcinoma, pancreatic cholangiocarcinoma gastric carcinomas. Swick BL,...
Calciphylaxis is a rare condition characterized by medial calcification of small- and medium-sized vessels that subsequently leads to ischemic necrosis. most often occurs in patients with end-stage renal disease secondary hyperparathyroidism. We present unique case calciphylaxis which the patient did not have disease. Instead, primary hyperparathyroidism and/or alcoholic cirrhosis were more likely causes her calciphylaxis. In addition, our demonstrated only but also fragmentation elastic...
: Histiocytoid Sweet syndrome is a histopathologic variant of characterized by an infiltrate mononuclear cells that have histiocytic appearance and represent immature granulocytes. The primary differential diagnosis for histiocytoid includes leukemia cutis true dermatoses. However, it does not usually include deep mycotic infection. Herein, we describe case in 75-year-old man which examination showed dense dermal composed mature neutrophils numerous yeast-like with surrounding halo,...
Evolving lesions of lichen sclerosus (LS) pose a diagnostic challenge owing to an absence classic findings epidermal atrophy, dermal sclerosis, band-like lymphocytic infiltrate and the presence eosinophils.Retrospective specimens LS were reviewed. Demographic information, biopsy vs. excision following histopathological characteristics noted: number eosinophils, hyperplasia, spongiosis, early/transitional LS, well-developed coexisting squamous cell carcinoma (SCC). Linear regression analysis...
Abstract Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMCT) is a recently described entity only 13 cases reported in the literature. Histopathologically, neoplasm consists of atypical epithelioid to spindled cells that form well‐circumscribed nodule usually confined dermis and subcutis cytological features including large vesicular nuclei prominent nucleoli abundant eosinophilic cytoplasm. Immunohistochemistry shows variable expressivity markers. Currently, there are limited data...