A5074867262- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- Cancer Research and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Circular RNAs in diseases
- Chronic Myeloid Leukemia Treatments
- DNA Repair Mechanisms
- Cytokine Signaling Pathways and Interactions
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
National and Kapodistrian University of Athens
2024
Alexander Fleming Biomedical Sciences Research Center
2024
Academy of Athens
2016-2021
Biomedical Research Foundation of the Academy of Athens
2016-2021
Scientific Report19 October 2016Open Access Transparent process Alternative lengthening of human telomeres is a conservative DNA replication with features break-induced Fani-Marlen Roumelioti Laboratory Genetics, Center Experimental Medicine and Translational Research, Biomedical Research Foundation the Academy Athens, Greece Search for more papers by this author Sotirios K Sotiriou Department Molecular Biology, University Geneva, Switzerland Vasiliki Katsini Maria Chiourea Thanos D...
Abstract Background Senescence is a fundamental biological process implicated in various pathologies, including cancer. Regarding carcinogenesis, senescence signifies, at least its initial phases, an anti-tumor response that needs to be circumvented for cancer progress. Micro-RNAs, subclass of regulatory, non-coding RNAs, participate regulation. At the subcellular level micro-RNAs, similar proteins, have been shown traffic between organelles influencing cellular behavior. The differential...
miRNAs constitute fine-tuners of gene expression and are implicated in a variety diseases spanning from inflammation to cancer. miRNA is deregulated rheumatoid arthritis (RA); however, their specific role key arthritogenic cells such as the synovial fibroblast (SF) remains elusive. Previous studies have shown that Mir221/222 upregulated RA SFs. Here, we demonstrate TNF IL-1β but not IFN-γ activated Mir221 /222 murine SF-specific overexpression huTNFtg mice led further expansion SFs disease...
Ongoing chromosomal instability in neoplasia (CIN) generates intratumor genomic heterogeneity and limits the efficiency of oncotherapeutics. Neoplastic human cells utilizing alternative lengthening telomeres (ALT)-pathway, display extensive structural numerical CIN. To unravel patterns genome evolution driven by oncogene-replication stress, telomere dysfunction, or genotoxic therapeutic interventions, we examined comparative hybridization five karyotypically-diverse outcomes ALT osteosarcoma...
Prostate cancer is one of the most common for men worldwide with advanced forms showing supernumerary or clustered centrosomes. Hematological and neurological expressed 1 (HN1) also known as Jupiter Microtubule Associated Homolog (JPT1) belongs to a small poorly understood family genes that are evolutionarily conserved across vertebrate species. The co-expression network HN1 from TCGA PRAD dataset indicates putative role in centrosome-related processes context prostate cancer. expression low...
An amendment to this paper has been published and can be accessed via the original article.