A5018818042- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- GDF15 and Related Biomarkers
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Chronic Myeloid Leukemia Treatments
- Inflammatory Bowel Disease
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Kruppel-like factors research
- Neonatal Respiratory Health Research
Friedrich-Alexander-Universität Erlangen-Nürnberg
2017-2021
Universitätsklinikum Erlangen
2020
Abstract Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism this tolerance-inducing effect alcohol, however, unknown. Here we show that alcohol and its metabolite acetate alter functional state T follicular helper (T FH ) cells in vitro vivo, thereby exerting immune regulatory properties. Alcohol-exposed mice have reduced Bcl6 PD-1 expression well IL-21 production by cells, preventing...
Group 2 innate lymphoid cells (ILC2s) possess indispensable roles during type 2–mediated inflammatory diseases. Although their physiological and detrimental immune functions seem to depend on the anatomical compartment they reside, tissue tropism molecular immunological processes regulating self-renewal of local pool ILC2s in context inflammation or infection are incompletely understood. Here, we analyzed role CC-chemokine receptor CCR8 for biological ILC2s. In vitro vivo experiments...
Cystic fibrosis patients suffer from a progressive, often fatal lung disease, which is based on complex interplay between chronic infections, locally accumulating immune cells and pulmonary tissue remodeling. Although group-2 innate lymphoid (ILC2s) act as crucial initiators of inflammation, our understanding their involvement in the pathogenesis cystic remains incomplete. Here we report marked decrease circulating CCR6+ ILC2s blood patients, significantly correlated with high disease...
While the role of T cells in regulation bone homeostasis is well defined, little known about innate lymphoid (ILCs) on bone. ILCs are immune that share cytokine expression patterns with but lack cell receptor. In this study we show type 2 (ILC2) potently inhibit generation resorbing osteoclasts vitro as favorably influence under steady state conditions vivo using loss and gain function models. Furthermore, adoptive transfer ILC2 completely abrogated ovariectomy-induced by significantly...
Cryptococcus neoformans is an opportunistic fungal pathogen preferentially causing disease in immunocompromised individuals such as organ-transplant-recipients, patients receiving immunosuppressive medications or, particular, suffering from HIV infection. Numerous studies clearly indicated that the control of C. infections strongly dependent on a prototypic type 1 immune response and classical macrophage activation, whereas 2-biased immunity alternative activation macrophages has been rather...
Abstract Here we investigated the role of NFAT-interacting protein (NIP)-45, an Interleukin (IL)-4 inducing Transcription Factor, and its impact on differentiation Group 2 Innate -Lymphoid -Cells (ILC2s) in pathogenesis asthma. NIP45 , a transcription factor regulating NFATc1 activity, mRNA was found to be induced Peripheral Blood mononuclear cells (PMBCs) asthmatic pre-school children with allergies peripheral blood CD4 + T from adult patients. In PBMCs control children, directly correlated...
Group 2 innate lymphoid cells (ILC2s) are a recently recognized subset of lymphocytes with crucial role in mucosal immunity and tissue homeostasis. Over the past decade, substantial advances our understanding ILC2 biology have established them as an essential element adaptive immunity. However, their relatively low abundance laborious purification from tissues make study difficult. Moreover, due to lack ILC2-specific Cre mouse-line, adoptive transfer ILC2s into ILC-deficient hosts is...
Abstract Upon contact to antigen, B cells differentiate into memory or antibody secreting short-lived long-lived plasma (PC). The survival of PCs depends on interaction with niches in the spleen bone marrow. However, molecular mechanisms controlling PC generation, migration, homing and are poorly understood. We recently reported that Krueppel-like factor 2 (KLF2) is an important regulator homeostasis. KLF2-deficient express lower levels factors, such as beta7-Integrin L-Selectin. Numbers...