A5025548935- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Reproductive System and Pregnancy
- Gut microbiota and health
- Barrier Structure and Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Ubiquitin and proteasome pathways
- Autoimmune and Inflammatory Disorders Research
- Helicobacter pylori-related gastroenterology studies
- Cytokine Signaling Pathways and Interactions
- Chemokine receptors and signaling
- GDF15 and Related Biomarkers
- Rheumatoid Arthritis Research and Therapies
- Adipokines, Inflammation, and Metabolic Diseases
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
- Dietary Effects on Health
- Parasites and Host Interactions
- Endoplasmic Reticulum Stress and Disease
- Neuropeptides and Animal Physiology
- Parasite Biology and Host Interactions
- Immune Response and Inflammation
Universitätsklinikum Erlangen
2018-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2018-2024
Gut microbial dysbiosis is associated with the development of autoimmune disease, but mechanisms by which affects transition from asymptomatic autoimmunity to inflammatory disease are incompletely characterized. Here, we identify intestinal barrier integrity as an important checkpoint in translating inflammation. Zonulin family peptide (zonulin), a potent regulator for tight junctions, highly expressed mice and humans can be used predict arthritis. Increased serum zonulin levels accompanied...
Abstract Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism this tolerance-inducing effect alcohol, however, unknown. Here we show that alcohol and its metabolite acetate alter functional state T follicular helper (T FH ) cells in vitro vivo, thereby exerting immune regulatory properties. Alcohol-exposed mice have reduced Bcl6 PD-1 expression well IL-21 production by cells, preventing...
Short-chain fatty acids are microbial metabolites that have been shown to be key regulators of the gut-joint axis in animal models. In humans, dysbiosis was observed rheumatoid arthritis (RA) patients as well those at-risk develop RA, and is thought an environmental trigger for development clinical disease. At same time, diet has a proven impact on maintaining intestinal homeostasis. Given this association, we performed feasibility study RA using high-fiber dietary supplementation with...
Group 2 innate lymphoid cells (ILC2s) were detected in the peripheral blood and joints of rheumatoid arthritis (RA) patients, serum-induced (SIA), collagen-induced (CIA) using flow cytometry. Circulating ILC2s significantly increased RA patients compared with healthy controls inversely correlated disease activity. Induction mice led to a fast increase ILC2 number. To elucidate role arthritis, loss- gain-of-function mouse models for subjected arthritis. Reduction numbers RORαcre/GATA3fl/fl...
While the role of T cells in regulation bone homeostasis is well defined, little known about innate lymphoid (ILCs) on bone. ILCs are immune that share cytokine expression patterns with but lack cell receptor. In this study we show type 2 (ILC2) potently inhibit generation resorbing osteoclasts vitro as favorably influence under steady state conditions vivo using loss and gain function models. Furthermore, adoptive transfer ILC2 completely abrogated ovariectomy-induced by significantly...
Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular events driven by abnormal platelet clotting effects. Platelets are produced megakaryocytes, deriving from megakaryocyte erythrocyte progenitors (MEP) in the bone marrow. Increased expansion across common autoimmune diseases was shown RA, systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS). In this context, we evaluated role of microbial-derived short chain fatty acid (SCFA) propionate on...
Butyrophilins are surface receptors belonging to the immunoglobulin superfamily. While several members of butyrophilin family have been implicated in development unconventional T cells, 2a2 (Btn2a2) has shown inhibit conventional cell activation. Here, we demonstrate that steady state, primary source Btn2a2 thymic epithelial cells (TEC). Absence alters maturation and bypasses central tolerance mechanisms. Furthermore, Btn2a2-/- mice develop spontaneous autoimmunity resembling human Sjögren's...
Alcohol is among the most widely consumed dietary substances. Excessive alcohol consumption damages liver, heart, and brain. also has strong immunoregulatory properties. Here, we report how impairs T cell function via acetylation of cortactin, a protein that binds filamentous actin facilitates branching. Upon consumption, acetate, metabolite alcohol, accumulates in lymphoid organs. cells exposed to exhibit increased cortactin. Acetylation cortactin inhibits binding hence reduces migration,...
Group 2 innate lymphoid cells (ILC2s) are a recently recognized subset of lymphocytes with crucial role in mucosal immunity and tissue homeostasis. Over the past decade, substantial advances our understanding ILC2 biology have established them as an essential element adaptive immunity. However, their relatively low abundance laborious purification from tissues make study difficult. Moreover, due to lack ILC2-specific Cre mouse-line, adoptive transfer ILC2s into ILC-deficient hosts is...
Innate lymphoid cells (ILC) not only are responsible for shaping the innate immune response but also actively modulate T cell responses. However, molecular processes regulating ILC-T interaction yet completely understood. The protein butyrophilin 2a2 (Btn2a2), a co-stimulatory molecule first identified on antigen-presenting cells, has pivotal role in maintenance of homeostasis, main effector and respective ligands remain elusive. We analyzed Btn2a2 cross talk. found that expression is...
The study objective was to assess the role of CCL19
Abstract Chronic inflammatory diseases, like rheumatoid arthritis (RA) have been described to cause central nervous system (CNS) activation. Less is known about environmental factors that enable the CNS suppress peripheral inflammation in RA. Here, we identified gut microbiota-derived histamine as such factor. We show low levels of activate enteric system, increase inhibitory neurotransmitter concentrations spinal cord and restore homeostatic microglia, thereby reducing joints. Selective 3...
Butyrophilins, which are members of the extended B7 family immunoregulators structurally related to family, have diverse functions on immune cells as co-stimulatory and co-inhibitory molecules. Despite recent advances in understanding butyrophilins’ role adaptive during infectious or autoimmune diseases, nothing is known about their bone homeostasis. Here, we analyzed one specific butyrophilin, namely Btn2a2, recently shown that Btn2a2 expressed monocyte/macrophage lineage also gives rise...
Summary Alcohol is among the most widely consumed dietary substances. Excessive alcohol consumption damages liver, heart and brain. also has strong immunoregulatory properties. Here we report how impairs T cell function via acetylation of cortactin, a protein that binds filamentous actin facilitates branching. Upon consumption, acetate, metabolite alcohol, accumulates in lymphoid organs. cells exposed to exhibit increased cortactin. Acetylation cortactin inhibits binding hence reduces...