A5068680399- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Barrier Structure and Function Studies
- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- Cancer, Stress, Anesthesia, and Immune Response
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bone Metabolism and Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Dermatology and Skin Diseases
- GDF15 and Related Biomarkers
- Adipokines, Inflammation, and Metabolic Diseases
- Parasites and Host Interactions
- Autoimmune and Inflammatory Disorders Research
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Parasite Biology and Host Interactions
- Alkaline Phosphatase Research Studies
- Systemic Lupus Erythematosus Research
- Myasthenia Gravis and Thymoma
- Food Allergy and Anaphylaxis Research
- Bone and Dental Protein Studies
Universitätsklinikum Erlangen
2017-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2017-2024
Center for Rheumatology
2023
Institute of Rheumatology
2023
Chiba University
2023
German Climate Computing Centre
2020
University of Virginia
2006-2010
Duke University
1989
Microbial metabolites are known to modulate immune responses of the host. The main derived from microbial fermentation dietary fibers in intestine, short-chain fatty acids (SCFA), affect local and systemic functions. Here we show that SCFA regulators osteoclast metabolism bone mass vivo. Treatment mice with as well feeding a high-fiber diet significantly increases prevents postmenopausal inflammation-induced loss. protective effects on associated inhibition differentiation resorption vitro...
Abstract Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are not well understood. Here we show that pentanoate, a physiologically abundant SCFA, is potent regulator of immunometabolism. Pentanoate induces IL-10 production in lymphocytes by reprogramming their metabolic activity towards elevated glucose oxidation. Mechanistically, this mediated supplying additional pentanoate-originated acetyl-CoA for histone acetyltransferases, and...
Gut microbial dysbiosis is associated with the development of autoimmune disease, but mechanisms by which affects transition from asymptomatic autoimmunity to inflammatory disease are incompletely characterized. Here, we identify intestinal barrier integrity as an important checkpoint in translating inflammation. Zonulin family peptide (zonulin), a potent regulator for tight junctions, highly expressed mice and humans can be used predict arthritis. Increased serum zonulin levels accompanied...
Abstract Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism this tolerance-inducing effect alcohol, however, unknown. Here we show that alcohol and its metabolite acetate alter functional state T follicular helper (T FH ) cells in vitro vivo, thereby exerting immune regulatory properties. Alcohol-exposed mice have reduced Bcl6 PD-1 expression well IL-21 production by cells, preventing...
Group 2 innate lymphoid cells (ILC2s) were detected in the peripheral blood and joints of rheumatoid arthritis (RA) patients, serum-induced (SIA), collagen-induced (CIA) using flow cytometry. Circulating ILC2s significantly increased RA patients compared with healthy controls inversely correlated disease activity. Induction mice led to a fast increase ILC2 number. To elucidate role arthritis, loss- gain-of-function mouse models for subjected arthritis. Reduction numbers RORαcre/GATA3fl/fl...
Chronic inflammatory diseases are often initiated and guided by the release of proinflammatory mediators. Rheumatoid arthritis (RA) is caused an imbalance between pro- anti-inflammatory mediators in joints, thereby favoring chronic inflammation joint damage. Here, we investigate if short-term high-fiber dietary intervention shifts this towards Healthy controls (n = 10) RA patients 29) under routine care received daily bars for 15 or 30 days, respectively. Stool sera were analyzed A resulted...
1. Small-intestine integrity in Caucasian and African patients infected with human immunodeficiency virus was determined by measuring the permeation across mucosa of two sugars, lactulose mannitol. 2. The sugars were assayed h.p.l.c. pulsed amperometric detection 6 h urine samples. Stool microscopy for enteropathogens performed all patients. 3. ratio to mannitol recovered increased advanced infection. Asymptomatic human-immunodeficiency-virus-infected subjects had a normal lactulose/mannitol...
While the role of T cells in regulation bone homeostasis is well defined, little known about innate lymphoid (ILCs) on bone. ILCs are immune that share cytokine expression patterns with but lack cell receptor. In this study we show type 2 (ILC2) potently inhibit generation resorbing osteoclasts vitro as favorably influence under steady state conditions vivo using loss and gain function models. Furthermore, adoptive transfer ILC2 completely abrogated ovariectomy-induced by significantly...
Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular events driven by abnormal platelet clotting effects. Platelets are produced megakaryocytes, deriving from megakaryocyte erythrocyte progenitors (MEP) in the bone marrow. Increased expansion across common autoimmune diseases was shown RA, systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS). In this context, we evaluated role of microbial-derived short chain fatty acid (SCFA) propionate on...
The association between inflammation and dysregulated bone remodeling is apparent in rheumatoid arthritis recapitulated the human tumor necrosis factor transgenic (hTNFtg) mouse model. We investigated whether extracellular binding immunoglobulin protein (BiP) would protect hTNFtg from both inflammatory as well extensive systemic loss BiP had direct antiosteoclast properties vitro.hTNFtg mice received a single intraperitoneal administration of at onset arthritis. Clinical disease parameters...
<h3>Background:</h3> Chronic peripheral inflammation is well-documented for its ability to alter the activation of central nervous system (CNS) in diseases such as rheumatoid arthritis (RA) [1]. Furthermore, CNS able regulate inflammatory processes periphery [2]. However, environmental factors facilitating CNS-mediated suppression RA remain less explored. The intestinal microbiota produces immunomodulatory metabolites, including short-chain fatty acids (SCFA) [3], and neuroactive substances...
Abstract Chronic inflammatory diseases, like rheumatoid arthritis (RA) have been described to cause central nervous system (CNS) activation. Less is known about environmental factors that enable the CNS suppress peripheral inflammation in RA. Here, we identified gut microbiota-derived histamine as such factor. We show low levels of activate enteric system, increase inhibitory neurotransmitter concentrations spinal cord and restore homeostatic microglia, thereby reducing joints. Selective 3...
<h3>Background</h3> Intestinal dysbiosis has been associated with the development and progression of rheumatoid arthritis (RA) [<i>1].</i> Microbiota-derived metabolites such as short-chain fatty acids (SCFA) gained attention in research inflammatory diseases promising targets for new therapeutics. Previous work our lab showed potent preventive effect SCFA on onset (<i>2, 3</i>). Although effective potential therapeutic approaches are arising, their underlying mechanisms remain elusive...
<h3>Background</h3> Besides the many well-characterised cellular and molecular components of innate adaptive immune system that influence inflammatory processes, recent characterisation lymphoid cells (ILC) has revealed an essential role for these populations in initiation, regulation resolution inflammation. Although low numbers, ILCs rapidly respond to cytokine microbial signals are potent sources multiple pro-inflammatory immunoregulatory cytokines. ILC2 depends on transcription factors...
Innate lymphoid cells 2 (ILC2) is a new immune cell lineage described in parasite defense and allergic inflammation. ILC2 were detected the peripheral blood joints of rheumatoid arthritis (RA) patients, serum-induced (SIA) collagen-induced (CIA) using flow cytometry. To elucidate role loss function (RORαcre/GATA3fl/fl mice) gain models (IL-25/IL-33 minicircles, IL-2/IL-2 antibody complex, adoptive transfer) for subjected to arthritis. Circulating ILC2s significantly increased RA compared...