A5073182851- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Occupational and environmental lung diseases
Friedrich-Alexander-Universität Erlangen-Nürnberg
2021-2022
Universitätsklinikum Erlangen
2021-2022
Karolinska Institutet
2021
Abstract Group 3 innate lymphoid cells (ILC3s) are crucial mediators of immunity and epithelial barrier function during immune responses against extracellular bacteria. Here, we identify Interferon regulatory factor 1 (IRF-1), a transcription previously associated with type immunity, as an essential regulator intestinal ILC3 accumulation effector cytokine production. We demonstrate that IRF-1 is upregulated in the context infection enteropathogen Citrobacter rodentium its presence central...
Malignant mesothelioma (MM) is an aggressive tumor of the serosal cavities. Angiogenesis important for progression, but so far, anti-angiogenic agents have not improved patient survival. Our hypothesis that better understanding regulation angiogenesis in this would largely improve success such a therapy. Syndecan-1 (SDC-1) transmembrane heparan sulfate proteoglycan acts as co-receptor various cellular processes including angiogenesis. In MM, expression SDC-1 generally low when present,...
A diverse spectrum of immune cells populates the intestinal mucosa reflecting continuous stimulation by luminal antigens. In lesions patients with inflammatory bowel disease, an aberrant process is characterized a very prominent infiltrate activated producing cytokines and chemokines. These mediators perpetuate inflammation or may contribute to mucosal protection depending on cellular context. order further characterize this complex cell network in inflammation, we investigated contribution...
Innate lymphoid cells (ILC) not only are responsible for shaping the innate immune response but also actively modulate T cell responses. However, molecular processes regulating ILC-T interaction yet completely understood. The protein butyrophilin 2a2 (Btn2a2), a co-stimulatory molecule first identified on antigen-presenting cells, has pivotal role in maintenance of homeostasis, main effector and respective ligands remain elusive. We analyzed Btn2a2 cross talk. found that expression is...