A5039744000- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Medical Imaging Techniques and Applications
- Congenital Diaphragmatic Hernia Studies
- Musculoskeletal pain and rehabilitation
- Respiratory and Cough-Related Research
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- MRI in cancer diagnosis
- COVID-19 Clinical Research Studies
- Foreign Body Medical Cases
- Viral gastroenteritis research and epidemiology
- Kawasaki Disease and Coronary Complications
- Radiation Dose and Imaging
- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Airway Management and Intubation Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Signaling Pathways in Disease
University of Regensburg
2021-2025
Universitätsklinikum Erlangen
2016-2024
Krankenhaus Barmherzige Brüder
2020-2024
Klinik und Poliklinik für Kinder- und Jugendmedizin
2023
St. Hedwig-Krankenhaus
2020
Universitätskinderklinik
2020
Kinderklinik Regensburg
2020
Friedrich-Alexander-Universität Erlangen-Nürnberg
2011-2020
Saarland University
2018
München Klinik Neuperlach
2003
Treatment with elexacaftor/tezacaftor/ivacaftor (ETI) improves multiple clinical outcomes in people cystic fibrosis (pwCF) at least one F508del allele. This study evaluated the real-world impact of ETI on lung function, nutritional status, pulmonary exacerbation frequency, and sweat chloride concentrations a large group pwCF.This observational cohort used data from German CF Registry for pwCF who received therapy were followed up period 12 months.The included 2645 67 centres Germany (mean...
We analysed the influence of rhinovirus (RV) in nasopharyngeal fluid (NPF) on type I and III interferon (IFN) responses ( e.g. IFN-α IFN - λ) their signal transduction, at baseline during disease exacerbation, cohorts pre-school children with without asthma. At time recruitment into Europe-wide study PreDicta, symptoms, NPF was collected local RV colonisation analysed. Peripheral blood mononuclear cells (PBMCs) were challenged vitro or not. RNA by quantitative real-time PCR gene arrays....
Abstract Background and objective Antimicrobial resistance (AMR) is a global crisis, however, relatively little known regarding its impact in chronic respiratory disease the specific challenges faced by healthcare workers across world this field. We aimed to assess worker views on they face AMR disease. Methods An online survey was sent globally working through European Respiratory Society clinical research collaboration (AMR-Lung) focussed lung Responses from different geographic regions...
Summary Background Respiratory syncytial virus (RSV) is one of the main causes morbidity in infants and young children worldwide. Current data on RSV-associated disease burden Germany before introduction new immunization strategies lacking. Methods The PAPI study a multicenter, prospective surveillance lower respiratory tract infections (LRTI) aged ≤ 24 months Germany. Results Data from 1607 with LRTI hospitalized twelve German hospitals between September 2021 May 2023 were analyzed. Among...
Abstract Purpose During fall 2021, children’s hospitals in Germany faced a surge RSV-related hospitalizations, whereas during fall/winter 2022–2023, RSV and influenza infections both led to increased inpatient admissions. Our study prospectively assessed severe acute respiratory infections, their causative pathogens, the resulting disease burden on German children's for 2023–2024 season. Methods From October 3, 2023 through April 16, 2024, children hospitalized with ARI as primary diagnosis...
Vitamin D3 (VitD3) is known to have immunomodulatory functions, and VitD3 deficiency associated with more severe asthma.We aimed assess the immunoregulatory effects of food supplementation on asthma manifestation, particular focus T cells type 2 innate lymphoid cells.Preschool children adult asthmatic cohorts were analyzed in context serum levels. In a murine model ovalbumin-induced asthma, diet sufficiency immune mechanisms investigated.We found less better-controlled phenotypes along...
Abstract Here we investigated the relationship between local bacterial colonization and anti-bacterial immune responses in pre-school asthmatic control children within EU-wide study PreDicta. In this cohort of children, nasopharyngeal with Gram-negative bacteria such as Haemophilus influenzae Moraxella catarrhalis was found to be associated highest interferon beta (IFNβ) IL-33 levels nasal pharyngeal fluids (NPF). IL33R-ST2 induced blood additional Gram + nasopharynx (Gr+/−). Furthermore,...
Abstract Background The PreDicta cohort was designed to prospectively evaluate wheeze/asthma persistence in preschoolers association with viral/microbial exposures and immunological responses. We present the design demographic/disease characteristics unsupervised predefined phenotypic subgroups at inclusion. Methods is a 2‐year prospective study conducted five European regions, including children 4‐6 years diagnosis of asthma as cases healthy age‐matched controls. At baseline, detailed...
Cystic fibrosis patients suffer from a progressive, often fatal lung disease, which is based on complex interplay between chronic infections, locally accumulating immune cells and pulmonary tissue remodeling. Although group-2 innate lymphoid (ILC2s) act as crucial initiators of inflammation, our understanding their involvement in the pathogenesis cystic remains incomplete. Here we report marked decrease circulating CCR6+ ILC2s blood patients, significantly correlated with high disease...
Introduction Interferon (IFN) responses have been reported to be defective in rhinovirus (RV)-induced asthma. The heterodimeric receptor of type I IFN (IFN-α/β) is composed IFN-αR1 and IFN-αR2. Ligand binding the IFN-α/β complex activates signal transducer activator transcription (STAT) proteins STAT1 STAT2 intracellularly. Although III (IFN-λ) binds a different containing IFN-λR1 interleukin-10R2, its triggering leads activation same downstream factors. Here, we analysed effects RV on...
In individuals with cystic fibrosis (CF), colonization methicillin-resistant Staphylococcus aureus (MRSA) was reported to be associated a deterioration of pulmonary disease as reflected by an accelerated decline in lung function. Thus, early eradication MRSA could beneficial these patients. Here, we report on intensified protocol.Since 2012 protocol for the newly acquired has been used our CF Clinic, combining oral rifampicin and fusidic acid, inhaled vancomycin, nasal mupirocin, local...
RANTES is implicated in allergic asthma and T cell-dependent clearance of infection. receptor family comprises CCR1, CCR3, CCR5, which are G-protein-coupled receptors consisting seven transmembrane helices. Infections with respiratory viruses like Rhinovirus cause induction production by epithelial cells. Here, we studied the role peripheral blood mononuclear cells cohorts children without validated extended this study to airways adults asthma. We further translated these studies a murine...
The cytokine interleukin-3 (IL-3) acts on early hematopoietic precursor cells. In humans, Treg cells secrete IL-3 and repress inflammatory except for basophils. present study aims to elucidate the contribution of in development course allergic asthma. We therefore analyzed secretion PBMCs total blood two cohorts pre-school children with without a murine model asthma, we phenotype IL-3-/- mice compared wild-type mice. from asthmatic showed increased secretion, which directly correlated...
Abstract Background We recently described increased NFATc1, IRF4 , and NIP45 messenger RNA (mRNA) expression in peripheral blood mononuclear cells (PBMCs) of asthmatic children adults with multiple allergies. Objective NFATc2 has been to associate induce interleukin‐4, be inhibited by T‐bet. Here, we analyzed the role adults. Methods PBMCs were isolated from control asthmatics subjects. Some untreated some cultured without phytohemagglutinin. Then, was extracted cytokines measured...
A hallmark of many respiratory conditions is the presence nocturnal symptoms. Nevertheless, especially in children there currently still a huge diagnostic gap detecting nighttime symptoms, which leads to an underestimation frequency clinical practise.We evaluated applicability and determined formal test characteristics LEOSound ® system, device for digital long-time recording automated detection acoustic airway events. Airway sounds were recorded overnight 115 adolescents (1-17 years) with...
Software-based image registration can improve the diagnostic value of imaging procedures and is an alternative to hybrid scanners. The aim this study was evaluate anatomical accuracy automatic rigid independently acquired datasets positron emission tomography with 18F-deoxyglucose abdominal magnetic resonance imaging.Analyses were performed on 28 lesions from 20 patients. PET data obtained using a stand-alone camera in 14 cases PET/CT scanner 9 cases. T1- T2-weighted MRI scans 1.5 T mean...