A5039087104- Forensic and Genetic Research
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Nutrition, Genetics, and Disease
- Digestive system and related health
- Genetic diversity and population structure
- RNA modifications and cancer
- Yersinia bacterium, plague, ectoparasites research
- Alcohol Consumption and Health Effects
- Race, Genetics, and Society
- Genetic Associations and Epidemiology
- Toxin Mechanisms and Immunotoxins
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Chemical Reactions and Isotopes
- Immunodeficiency and Autoimmune Disorders
- Bacteriophages and microbial interactions
- Diet, Metabolism, and Disease
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Liver Disease Diagnosis and Treatment
- Transgenic Plants and Applications
Lomonosov Moscow State University
2012-2021
Vavilov Institute of General Genetics
2010-2021
Russian Academy of Sciences
2000-2015
Moscow State University
2012-2013
Moscow Institute of Physics and Technology
2012-2013
Institute of Developmental Physiology
2008
Research Institute of Medical Genetics of Russian Academy of Medical Sciences
2006
Karolinska Institutet
1998
Sophiahemmet Hospital
1998
Integrated Cardio Metabolic Centre
1998
Summary Mitochondrial aldehyde dehydrogenase (ALDH2) is one of the most important enzymes in human alcohol metabolism. The oriental ALDH2*504Lys variant functions as a dominant negative, greatly reducing activity heterozygotes and abolishing homozygotes. This allele associated with serious disorders such liver disease, late onset Alzheimer colorectal cancer, esophageal best known for protection against alcoholism. Many hundreds papers various languages have been published on this variant,...
The Slavic branch of the Balto-Slavic sub-family Indo-European languages underwent rapid divergence as a result spatial expansion its speakers from Central-East Europe, in early medieval times. This expansion–mainly to East Europe and northern Balkans–resulted incorporation genetic components numerous autochthonous populations into gene pools. Here, we characterize variation all extant ethnic groups speaking by analyzing mitochondrial DNA (n = 6,876), Y-chromosomes 6,079) genome-wide SNP...
Frequent deletions and loss of heterozygosity in a segment chromosome 13 (13q14) cases B-cell chronic lymphocytic leukemia (CLL) have suggested that this malignancy is caused by inactivation an unknown tumor suppressor gene located region. Toward the identification putative CLL suppressor, we constructed high-resolution physical map YAC, PAC, cosmid contigs covering 600 kb 13q14 genomic In addition to densely positioned genetic markers STSs, was further annotated localization 32 transcribed...
Abstract Background Astrocyte activation is a characteristic response to injury in the central nervous system, and can be either neurotoxic or neuroprotective, while regulation of both roles remains elusive. Methods To decipher regulatory elements controlling astrocyte-mediated neurotoxicity glaucoma, we conducted systems-level functional analysis gene expression, proteomic genetic data associated with reactive optic nerve head astrocytes (ONHAs). Results Our reconstruction molecular...
The article presents the results of first regular study Russian populations by sequencing control region mitochondrial DNA (mtDNA). sequenced is most variable on mtDNA molecule and commonly used for population evolutionary studies. Russians form one largest ethnic groups (more than 129 million). However, their genetic diversity had only been characterized with RFLP biochemical markers, although there are already established sequence databases many world. We have obtained data from 103...
B-cell chronic lymphocytic leukemia (B-CLL) is a human hematological neoplastic disease often associated with the loss of chromosome 13 region between RB1 gene and locus D13S25. A new tumor suppressor (TSG) may be located in region. cosmid contig has been constructed loci D13S1168 (WI9598) D13S25 (H2-42), which corresponds to minimal shared by B-CLL deletions. The includes more than 200 LANL ICRF clones covering 620 kb. Three cDNAs likely corresponding three different genes have found...
A computer‐based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set tumours versus normal tissues. list EST clusters highly represented rarely observed tissues as resulting output file program. These differentially expressed (genes) can be useful developing new tumour markers prognostic indicators wide human malignancies. Tumour‐specific protein‐coding genes may considered manifestation tumour‐specific gene expression.
We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues some tumor cell lines. Protein high homology to tetramerization domain voltage‐gated K + channels. Using patch‐clamp technique we determined suppresses channel activity human prostate line LNCaP. It is known selective blockers channels suppress lymphocyte LNCaP proliferation. suggest candidate...
Seventeen population groups within the Russian Federation were characterized for first time using a panel of 15 genetic markers that are used DNA identification and in forensic medical examinations. The degree polymorphism diversity microsatellite loci Power Plex system (Promega) populations; distribution alleles genotypes populations six cities 11 ethnic Federation; levels intra- interpopulation differentiation population; relations between characteristics under study determined....
OBJECTIVES: The environmental and life-style conditions of the Kola Sami could have influenced population-specific frequencies AGXTProIILeu allele, certain alleles APOE LCT genes, involved respectively, in metabolism animal proteins, lipids milk sugar. Study Design. DNA samples were collected from population Lovozero settlement (Murmansk Region) 2005.METHODS: analysis traditional diet was made using data ethnographic studies conducted nineteenth beginning twentieth centuries. Frequencies...
Studies of ancient DNA specimens started 25 years ago. At that time short mitochondrial (mtDNA) fragments were the main targets in studies. The last three especially productive development new methods purification and analysis. Complete mtDNA molecules relatively large nuclear are studies today. Ancient allowed us to study organisms went extinct more than ten thousand ago, reconstruct their phenotypic traits evolution. analyses can help understand human populations how they migrated. A...