A5024483501- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Bone health and treatments
- Bone health and osteoporosis research
- Mast cells and histamine
- Bone and Joint Diseases
- Bone Metabolism and Diseases
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Urticaria and Related Conditions
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Systemic Sclerosis and Related Diseases
- melanin and skin pigmentation
- Asthma and respiratory diseases
- Dermatological and Skeletal Disorders
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Food Allergy and Anaphylaxis Research
- RNA Research and Splicing
- Immune cells in cancer
- Heterotopic Ossification and Related Conditions
Université de Toulouse
2017-2025
Centre Hospitalier Universitaire de Toulouse
2009-2025
Inserm
2013-2025
Université Toulouse III - Paul Sabatier
2013-2024
Hôpital Purpan
2011-2024
Centre National de la Recherche Scientifique
2013-2024
Hôpital Paule de Viguier
2016-2024
French Clinical Research Infrastructure Network
2024
Lancaster University
2023
Hôpital de La Grave
2014-2022
Macrophages contribute to the pathogenesis of rheumatoid arthritis (RA). They can display different states activation or “polarization”, notably so-called inflammatory “M1” and various alternative “M2” polarizations, characterized by distinct functions. Data regarding effects RA anti-cytokine biological disease-modifying anti-rheumatic drugs (bDMARDs) on macrophage polarization are scarce. We aimed assess in vitro modulation bDMARDs targeting pro-inflammatory cytokines RA. generated monocyte...
Dear Editor, Beck et al. [1] recently identified a genetic disorder that connects seemingly unrelated adult-onset inflammatory syndromes as VEXAS syndrome. We report case of syndrome in patient with previous SpA favourable response to i.v. immunoglobulin and anti-IL17 therapy. In 2010, diagnosis was made 57-year-old man, who had back pain, peripheral arthritis, bilateral active sacroiliitis on MRI (Fig. 1A) HLA- B27–positive testing [2]. After failure several NSAIDs, the initiation anti-TNF...
In the stressful context of coronavirus disease 2019 (COVID-19) pandemic, some reports have raised concerns regarding psychiatric disorders with use hydroxychloroquine. this study, we reviewed all adverse effects hydroxychloroquine in COVID-19 patients, as well other indications, reported VigiBase, World Health Organization's (WHO) global database individual case safety reports. First, analyzed effects, including suicide, patients to 16 June 2020. We also performed disproportionality...
Introduction: Adipose-derived mesenchymal stem cells (ADSC) have been shown to remarkable immune-modulating effects. However, their efficacy in clinical trials has yet be fully demonstrated. This could due a lack of proper inflammatory environment vivo that primes ADSC. Here, we define how the articular microenvironment rheumatoid arthritis (RA) patients modulates therapeutic efficiency Methods: Synovial fluids (SF) were collected from 8 RA patients, 2 Spondyloarthritis and one control...
To search for association between ultrasound (US) enthesis abnormalities and disease activity, spine sacro-iliac joints (SIJ) MRI inflammatory lesions structural changes in a cohort of patients suspected axial spondyloarthritis (SpA).Patients: Of 708 included the DESIR(Devenir des Spondyloarthrites Indifférenciées Récentes) cohort, 402 had an US assessment were selected this study. Imaging: Achilles, lateral epicondyles, superior patellar ligament, inferior ligament entheses systematically...
Abstract Introduction Our objective was to assess the capacity of dendrimer aza-bis-phosphonate (ABP) modulate phenotype monocytes (Mo) and derived dendritic cells (MoDC) activated in response toll-like receptor 4 (TLR4) interferon γ (IFN- γ) stimulation. Methods Mo ( n = 12) MoDC 11) from peripheral blood healthy donors were prepared. Cells preincubated or not for 1 hour with ABP, then incubated lipopolysaccharide (LPS; as a TLR4 ligand) (IFN-γ) 38 hours. Secretion tumor necrosis factor α...
Objectives We compared the ability of antibodies against cyclic citrullinated peptides (anti-CCP2), mutated vimentin (anti-MCV) and fibrinogen (AhFibA) to predict 1 year rapid radiographic progression (RRP; total Sharp score variation ≥5 points), in early rheumatoid arthritis (RA). Methods analysed 566 patients from ESPOIR cohort with RA fulfilling 2010 American College Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria at 1. assayed 3 anticitrullinated peptide (ACPA) tests...
Objectives To compare the risk of serious adverse events, infections and death caused by methotrexate biological disease-modifying antirheumatic drug (bDMARD) combination therapy versus a bDMARD prescribed as monotherapy in rheumatoid arthritis (RA). Methods A systematic literature review was conducted until February 2016 PubMed, Embase Cochrane Library databases selecting randomised controlled trials comparing to RA. The meta-analysis compared occurrence (1) (2) (3) among these groups...